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Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment.
BMC Cancer. 2009 Aug 20; 9:288.BC

Abstract

BACKGROUND

The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment.

METHODS

Between January 1996 and December 2006, a total of 1367 CRC patients who underwent surgical treatment in Kaohsiung Medical University Hospital were analyzed. We retrospectively investigated clinicopathologic features of these patients. All patients were followed up intensively, and their outcomes were investigated completely.

RESULTS

Of 1367 CRC patients, there were seven hundred and fifty-seven males (55.4%) and 610 (44.6%) females. The median follow-up period was 60 months (range, 3-132 months). A multivariate analysis identified that low serum albumin level (P = 0.011), advanced UICC stage (P < 0.001), and high carcinoembryonic antigen (CEA) level (P < 0.001) were independent prognostic factors of cancer-specific survival. Meanwhile, a multivariate analysis showed age over 65 years (P < 0.001), advanced UICC stage (P < 0.001), and high CEA level (P < 0.001) were independent prognostic factors of overall survival. Furthermore, combination of UICC stage, serum CEA and albumin levels as predictors of cancer-specific survival showed that the poorer the prognostic factors involved, the poorer the cancer-specific survival rate. Likewise, combination of UICC stage, age and serum CEA level as predictors of overall survival showed that the poorer the prognostic factors involved, the poorer the overall survival rate. Of these prognostic factors, preoperative serum CEA level was the only significant prognostic factor for patients with stage II and III CRCs in both cancer-specific and overall survival categories.

CONCLUSION

Preoperative serum albumin level, CEA level and age could prominently affect postoperative outcome of CRC patients undergoing surgical treatment. In addition to conventional UICC staging system, it might be imperative to take these additional characteristics of factors into account in CRC patients prior to surgical treatment.

Authors+Show Affiliations

Nutrition Service Team, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC. lichsu@cc.kmu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19691850

Citation

Sun, Li-Chu, et al. "Preoperative Serum Carcinoembryonic Antigen, Albumin and Age Are Supplementary to UICC Staging Systems in Predicting Survival for Colorectal Cancer Patients Undergoing Surgical Treatment." BMC Cancer, vol. 9, 2009, p. 288.
Sun LC, Chu KS, Cheng SC, et al. Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment. BMC Cancer. 2009;9:288.
Sun, L. C., Chu, K. S., Cheng, S. C., Lu, C. Y., Kuo, C. H., Hsieh, J. S., Shih, Y. L., Chang, S. J., & Wang, J. Y. (2009). Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment. BMC Cancer, 9, 288. https://doi.org/10.1186/1471-2407-9-288
Sun LC, et al. Preoperative Serum Carcinoembryonic Antigen, Albumin and Age Are Supplementary to UICC Staging Systems in Predicting Survival for Colorectal Cancer Patients Undergoing Surgical Treatment. BMC Cancer. 2009 Aug 20;9:288. PubMed PMID: 19691850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment. AU - Sun,Li-Chu, AU - Chu,Koung-Shing, AU - Cheng,Su-Chen, AU - Lu,Chien-Yu, AU - Kuo,Chao-Hung, AU - Hsieh,Jan-Sing, AU - Shih,Ying-Ling, AU - Chang,Shun-Jen, AU - Wang,Jaw-Yuan, Y1 - 2009/08/20/ PY - 2009/05/13/received PY - 2009/08/20/accepted PY - 2009/8/21/entrez PY - 2009/8/21/pubmed PY - 2009/12/16/medline SP - 288 EP - 288 JF - BMC cancer JO - BMC Cancer VL - 9 N2 - BACKGROUND: The aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment. METHODS: Between January 1996 and December 2006, a total of 1367 CRC patients who underwent surgical treatment in Kaohsiung Medical University Hospital were analyzed. We retrospectively investigated clinicopathologic features of these patients. All patients were followed up intensively, and their outcomes were investigated completely. RESULTS: Of 1367 CRC patients, there were seven hundred and fifty-seven males (55.4%) and 610 (44.6%) females. The median follow-up period was 60 months (range, 3-132 months). A multivariate analysis identified that low serum albumin level (P = 0.011), advanced UICC stage (P < 0.001), and high carcinoembryonic antigen (CEA) level (P < 0.001) were independent prognostic factors of cancer-specific survival. Meanwhile, a multivariate analysis showed age over 65 years (P < 0.001), advanced UICC stage (P < 0.001), and high CEA level (P < 0.001) were independent prognostic factors of overall survival. Furthermore, combination of UICC stage, serum CEA and albumin levels as predictors of cancer-specific survival showed that the poorer the prognostic factors involved, the poorer the cancer-specific survival rate. Likewise, combination of UICC stage, age and serum CEA level as predictors of overall survival showed that the poorer the prognostic factors involved, the poorer the overall survival rate. Of these prognostic factors, preoperative serum CEA level was the only significant prognostic factor for patients with stage II and III CRCs in both cancer-specific and overall survival categories. CONCLUSION: Preoperative serum albumin level, CEA level and age could prominently affect postoperative outcome of CRC patients undergoing surgical treatment. In addition to conventional UICC staging system, it might be imperative to take these additional characteristics of factors into account in CRC patients prior to surgical treatment. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/19691850/Preoperative_serum_carcinoembryonic_antigen_albumin_and_age_are_supplementary_to_UICC_staging_systems_in_predicting_survival_for_colorectal_cancer_patients_undergoing_surgical_treatment_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-288 DB - PRIME DP - Unbound Medicine ER -