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Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes.
Med Hypotheses. 2010 Jan; 74(1):71-5.MH

Abstract

Over the past decade, new evidence has shown that vitamin D deficiency may contribute to the risk of developing a wide range of common chronic diseases that are different from the classic action on calcium and bone homeostasis. Acting through the vitamin D receptor, vitamin D can produce a wide array of favorable biological effects via genomic, non-genomic or intracrine mechanisms and, therefore, contributes to the improvement of human health in humans. We hypothesize that some of these effects may be even more critical during pregnancy. The focus of this paper is to review the data on the classic and non-classic actions of vitamin D with regards to pregnancy. It appears that vitamin D insufficiency during pregnancy is potentially associated with increased risk of preeclampsia, insulin resistance and gestational diabetes mellitus. Furthermore, experimental data also anticipate that vitamin D sufficiency is critical for fetal development, and especially for fetal brain development and immunological functions. Vitamin D deficiency during pregnancy may, therefore, not only impair maternal skeletal preservation and fetal skeletal formation but also be vital to the fetal "imprinting" that may affect chronic disease susceptibility soon after birth as well as later in life.

Authors+Show Affiliations

Paris Descartes University, Paris, France. alexandre.lapillonne@svp.aphp.fr

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19692182

Citation

Lapillonne, Alexandre. "Vitamin D Deficiency During Pregnancy May Impair Maternal and Fetal Outcomes." Medical Hypotheses, vol. 74, no. 1, 2010, pp. 71-5.
Lapillonne A. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Med Hypotheses. 2010;74(1):71-5.
Lapillonne, A. (2010). Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Medical Hypotheses, 74(1), 71-5. https://doi.org/10.1016/j.mehy.2009.07.054
Lapillonne A. Vitamin D Deficiency During Pregnancy May Impair Maternal and Fetal Outcomes. Med Hypotheses. 2010;74(1):71-5. PubMed PMID: 19692182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. A1 - Lapillonne,Alexandre, Y1 - 2009/08/18/ PY - 2009/06/30/received PY - 2009/07/30/accepted PY - 2009/8/21/entrez PY - 2009/8/21/pubmed PY - 2010/3/17/medline SP - 71 EP - 5 JF - Medical hypotheses JO - Med Hypotheses VL - 74 IS - 1 N2 - Over the past decade, new evidence has shown that vitamin D deficiency may contribute to the risk of developing a wide range of common chronic diseases that are different from the classic action on calcium and bone homeostasis. Acting through the vitamin D receptor, vitamin D can produce a wide array of favorable biological effects via genomic, non-genomic or intracrine mechanisms and, therefore, contributes to the improvement of human health in humans. We hypothesize that some of these effects may be even more critical during pregnancy. The focus of this paper is to review the data on the classic and non-classic actions of vitamin D with regards to pregnancy. It appears that vitamin D insufficiency during pregnancy is potentially associated with increased risk of preeclampsia, insulin resistance and gestational diabetes mellitus. Furthermore, experimental data also anticipate that vitamin D sufficiency is critical for fetal development, and especially for fetal brain development and immunological functions. Vitamin D deficiency during pregnancy may, therefore, not only impair maternal skeletal preservation and fetal skeletal formation but also be vital to the fetal "imprinting" that may affect chronic disease susceptibility soon after birth as well as later in life. SN - 1532-2777 UR - https://www.unboundmedicine.com/medline/citation/19692182/Vitamin_D_deficiency_during_pregnancy_may_impair_maternal_and_fetal_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(09)00545-3 DB - PRIME DP - Unbound Medicine ER -