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Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy.
Am J Psychiatry 1990; 147(4):445-51AJ

Abstract

Because of the efficacy of specific gamma-aminobutyric acid (GABA) agonists in tardive dyskinesia, the authors tested the benzodiazepine clonazepam in a 12-week, double-blind, placebo-controlled, randomized crossover trial in 19 chronically ill patients with tardive dyskinesia who were being treated with neuroleptics. They found a 35% decrease in dyskinesia ratings with clonazepam treatment. The six patients with predominantly dystonic symptoms showed greater benefit than the 13 patients with predominantly choreoathetoid dyskinesias. Tolerance developed to the antidyskinetic effect of clonazepam in the five patients whose long-term use of the drug was followed, but a 2-week clonazepam-free period recaptured its antidyskinetic effect.

Authors+Show Affiliations

Maryland Psychiatric Research Center, Department of Psychiatry, Baltimore 21228.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1969244

Citation

Thaker, G K., et al. "Clonazepam Treatment of Tardive Dyskinesia: a Practical GABAmimetic Strategy." The American Journal of Psychiatry, vol. 147, no. 4, 1990, pp. 445-51.
Thaker GK, Nguyen JA, Strauss ME, et al. Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy. Am J Psychiatry. 1990;147(4):445-51.
Thaker, G. K., Nguyen, J. A., Strauss, M. E., Jacobson, R., Kaup, B. A., & Tamminga, C. A. (1990). Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy. The American Journal of Psychiatry, 147(4), pp. 445-51.
Thaker GK, et al. Clonazepam Treatment of Tardive Dyskinesia: a Practical GABAmimetic Strategy. Am J Psychiatry. 1990;147(4):445-51. PubMed PMID: 1969244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy. AU - Thaker,G K, AU - Nguyen,J A, AU - Strauss,M E, AU - Jacobson,R, AU - Kaup,B A, AU - Tamminga,C A, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 445 EP - 51 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 147 IS - 4 N2 - Because of the efficacy of specific gamma-aminobutyric acid (GABA) agonists in tardive dyskinesia, the authors tested the benzodiazepine clonazepam in a 12-week, double-blind, placebo-controlled, randomized crossover trial in 19 chronically ill patients with tardive dyskinesia who were being treated with neuroleptics. They found a 35% decrease in dyskinesia ratings with clonazepam treatment. The six patients with predominantly dystonic symptoms showed greater benefit than the 13 patients with predominantly choreoathetoid dyskinesias. Tolerance developed to the antidyskinetic effect of clonazepam in the five patients whose long-term use of the drug was followed, but a 2-week clonazepam-free period recaptured its antidyskinetic effect. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/1969244/Clonazepam_treatment_of_tardive_dyskinesia:_a_practical_GABAmimetic_strategy_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.147.4.445?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -