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Progesterone levels and carotid intima-media thickness: a negative association in older northern Chinese men.
Tex Heart Inst J 2009; 36(4):303-8TH

Abstract

In experimental research, progesterone has been found to be beneficial to the central nervous and cardiovascular systems; however, its potential role in preventing atherosclerosis in elderly men remains unclear. In this prospective study, we analyzed data in 385 older men and women from 6 communities in Beijing, China, in order to discover whether progesterone is associated with carotid intima-media thickness and plaque occurrence. Intima-media thickness and atherosclerotic plaques were determined by use of ultrasonography. Sex-hormone levels were measured by immunoassay. The data were analyzed via analysis of covariance and logistic regression analysis; P < 0.05 was considered statistically significant. We found a negative association between mean intima-media thickness and progesterone concentration in men, before and after adjustments for such traditional risk factors of atherosclerosis as age, triglyceride levels, total and low-density lipoprotein cholesterol levels, high-sensitivity C-reactive protein, systolic blood pressure, waist-to-hip ratio, and body mass index (analysis of covariance, P = 0.007 and P = 0.015, respectively). However, no such association was found in women (P = 0.304 and P = 0.247, respectively). In the logistic regression model that was adjusted for the confounding factors of atherosclerosis, men with progesterone levels in the lowest quartile (<1.87 nmol/L) had more risk of higher intima-media thickness (odds ratio, 2.15; P = 0.042). Although further experimental and prospective studies are warranted in order to determine the mechanism of progesterone's function in atherosclerosis prevention, we conclude that progesterone concentrations are negatively associated with carotid artery atherosclerosis in northern Chinese men 60 years of age or older.

Authors+Show Affiliations

Institute of Nephrology of PLA, General Hospital of PLA, 28 Fuxing Road, Beijing 100853, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19693303

Citation

Ma, Qiang, et al. "Progesterone Levels and Carotid Intima-media Thickness: a Negative Association in Older Northern Chinese Men." Texas Heart Institute Journal, vol. 36, no. 4, 2009, pp. 303-8.
Ma Q, Sun X, Chen Y, et al. Progesterone levels and carotid intima-media thickness: a negative association in older northern Chinese men. Tex Heart Inst J. 2009;36(4):303-8.
Ma, Q., Sun, X., Chen, Y., Chen, X., Zhi, G., & Tan, G. (2009). Progesterone levels and carotid intima-media thickness: a negative association in older northern Chinese men. Texas Heart Institute Journal, 36(4), pp. 303-8.
Ma Q, et al. Progesterone Levels and Carotid Intima-media Thickness: a Negative Association in Older Northern Chinese Men. Tex Heart Inst J. 2009;36(4):303-8. PubMed PMID: 19693303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progesterone levels and carotid intima-media thickness: a negative association in older northern Chinese men. AU - Ma,Qiang, AU - Sun,Xuefeng, AU - Chen,Yunshuang, AU - Chen,Xiangmei, AU - Zhi,Guang, AU - Tan,Guojuan, PY - 2009/8/21/entrez PY - 2009/8/21/pubmed PY - 2009/10/30/medline KW - Aging/blood KW - analysis of variance KW - atherosclerosis/prevention & control KW - carotid arteries/pathology/physiology/ultrasonography KW - cohort studies KW - muscle, smooth, vascular/physiopathology KW - progesterone/physiology KW - risk factors KW - sex characteristics SP - 303 EP - 8 JF - Texas Heart Institute journal JO - Tex Heart Inst J VL - 36 IS - 4 N2 - In experimental research, progesterone has been found to be beneficial to the central nervous and cardiovascular systems; however, its potential role in preventing atherosclerosis in elderly men remains unclear. In this prospective study, we analyzed data in 385 older men and women from 6 communities in Beijing, China, in order to discover whether progesterone is associated with carotid intima-media thickness and plaque occurrence. Intima-media thickness and atherosclerotic plaques were determined by use of ultrasonography. Sex-hormone levels were measured by immunoassay. The data were analyzed via analysis of covariance and logistic regression analysis; P < 0.05 was considered statistically significant. We found a negative association between mean intima-media thickness and progesterone concentration in men, before and after adjustments for such traditional risk factors of atherosclerosis as age, triglyceride levels, total and low-density lipoprotein cholesterol levels, high-sensitivity C-reactive protein, systolic blood pressure, waist-to-hip ratio, and body mass index (analysis of covariance, P = 0.007 and P = 0.015, respectively). However, no such association was found in women (P = 0.304 and P = 0.247, respectively). In the logistic regression model that was adjusted for the confounding factors of atherosclerosis, men with progesterone levels in the lowest quartile (<1.87 nmol/L) had more risk of higher intima-media thickness (odds ratio, 2.15; P = 0.042). Although further experimental and prospective studies are warranted in order to determine the mechanism of progesterone's function in atherosclerosis prevention, we conclude that progesterone concentrations are negatively associated with carotid artery atherosclerosis in northern Chinese men 60 years of age or older. SN - 1526-6702 UR - https://www.unboundmedicine.com/medline/citation/19693303/Progesterone_levels_and_carotid_intima_media_thickness:_a_negative_association_in_older_northern_Chinese_men_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=19693303.ui DB - PRIME DP - Unbound Medicine ER -