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Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice.
Pharmazie. 2009 Jul; 64(7):472-6.P

Abstract

LMPAB is a linear beta-(1-3)-glucan we isolated from polysaccharide extract of Agaricus blazei Murill (AbM). Effects of LMPAB on splenic natural killer (NK) cell activity, splenocyte proliferation, index of spleen and thymus, IFN-gamma expression in spleen and the concentration of IL-12, IL-18 and TNF-alpha in serum of S180 ascitic tumor-bearing mice were detected. The results showed that intraperitoneal injection of LMPAB (100 mg x kg(-1) x d(-1)) significantly increased the thymus index. LMPAB augmented splenic NK cell activity in a dose-dependent manner (50-200 mg x kg(-1) x d(-1)). The concanavalin A (3 microg/ ml) stimulated splenocyte proliferation was significantly enhanced by LMPAB at dosages of 50, 100 or 200 mg x kg(-1) x d(-1). Further studies showed that LMPAB (50, 100 or 200 mg x kg(-1) x d(-1), 14d) significantly increased the production of IL-12, TNF-alpha, IL-18 and the expression IFN-gamma as determined by ELISA and immunohistochemistry, respectively. These results clearly indicate that the anti-tumor effects of LMPAB are closely associated with up-regulation of activity of NK cells, expression of IFN-gamma in spleen and the systemic level of IL-12, IL-18 and TNF-alpha in tumor-bearing mice.

Authors+Show Affiliations

The Institute of Medicine, Qiqihar Medical College, 249 Heping Road, Fula'erji District, Qiqihar 161042, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19694186

Citation

Niu, Ying-Cai, et al. "Immunostimulatory Activities of a Low Molecular Weight Antitumoral Polysaccharide Isolated From Agaricus Blazei Murill (LMPAB) in Sarcoma 180 Ascitic Tumor-bearing Mice." Die Pharmazie, vol. 64, no. 7, 2009, pp. 472-6.
Niu YC, Liu JC, Zhao XM, et al. Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice. Pharmazie. 2009;64(7):472-6.
Niu, Y. C., Liu, J. C., Zhao, X. M., Su, F. Q., & Cui, H. X. (2009). Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice. Die Pharmazie, 64(7), 472-6.
Niu YC, et al. Immunostimulatory Activities of a Low Molecular Weight Antitumoral Polysaccharide Isolated From Agaricus Blazei Murill (LMPAB) in Sarcoma 180 Ascitic Tumor-bearing Mice. Pharmazie. 2009;64(7):472-6. PubMed PMID: 19694186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice. AU - Niu,Ying-Cai, AU - Liu,Ji-Cheng, AU - Zhao,Xue-Mei, AU - Su,Fu-Qin, AU - Cui,Hong-Xia, PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2009/9/18/medline SP - 472 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 64 IS - 7 N2 - LMPAB is a linear beta-(1-3)-glucan we isolated from polysaccharide extract of Agaricus blazei Murill (AbM). Effects of LMPAB on splenic natural killer (NK) cell activity, splenocyte proliferation, index of spleen and thymus, IFN-gamma expression in spleen and the concentration of IL-12, IL-18 and TNF-alpha in serum of S180 ascitic tumor-bearing mice were detected. The results showed that intraperitoneal injection of LMPAB (100 mg x kg(-1) x d(-1)) significantly increased the thymus index. LMPAB augmented splenic NK cell activity in a dose-dependent manner (50-200 mg x kg(-1) x d(-1)). The concanavalin A (3 microg/ ml) stimulated splenocyte proliferation was significantly enhanced by LMPAB at dosages of 50, 100 or 200 mg x kg(-1) x d(-1). Further studies showed that LMPAB (50, 100 or 200 mg x kg(-1) x d(-1), 14d) significantly increased the production of IL-12, TNF-alpha, IL-18 and the expression IFN-gamma as determined by ELISA and immunohistochemistry, respectively. These results clearly indicate that the anti-tumor effects of LMPAB are closely associated with up-regulation of activity of NK cells, expression of IFN-gamma in spleen and the systemic level of IL-12, IL-18 and TNF-alpha in tumor-bearing mice. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/19694186/Immunostimulatory_activities_of_a_low_molecular_weight_antitumoral_polysaccharide_isolated_from_Agaricus_blazei_Murill__LMPAB__in_Sarcoma_180_ascitic_tumor_bearing_mice_ L2 - https://antibodies.cancer.gov/detail/CPTC-IL18-4 DB - PRIME DP - Unbound Medicine ER -