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High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trial.
Eur Rev Med Pharmacol Sci 2009 Jul-Aug; 13(4):279-83ER

Abstract

OBJECTIVE

Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using a higher dose of arginine (20 g per day) could improve nutritional variables.

MATERIALS AND METHODS

A population of 72 patients with oral and laryngeal cancer was enrolled. At surgery patients were randomly allocated to two groups: a) patients were receiving an enteral diet supplements with arginine and fiber (group I); b) patients were receiving an isocaloric, isonitrogenous enteral formula (group II).

RESULTS

No significant intergroup differences in the trend of the three serum proteins and lymphocytes were detected. Gastrointestinal tolerance (diarrhea) of both formulas was good (7.89% group I and 5.88% group II: ns). The postoperative infections complications were similar in both groups (23.6% group I and 20.6% group II: ns). Fistula was less frequent in enriched nutrition group (5.2% group I and 17.6% group II: p = 0.026). The length of postoperative stay was better 24.3 +/- 14 days in the immunonutrition group than 36.1 +/- 27 days in the control group (p = 0.036).

CONCLUSIONS

Enriched formula improves local wound complications in postoperative head and neck cancer patients and decreases length of stay.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, Valladolid, Spain. dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19694342

Citation

De Luis, D A., et al. "High Dose of Arginine Enhanced Enteral Nutrition in Postsurgical Head and Neck Cancer Patients. a Randomized Clinical Trial." European Review for Medical and Pharmacological Sciences, vol. 13, no. 4, 2009, pp. 279-83.
De Luis DA, Izaola O, Cuellar L, et al. High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trial. Eur Rev Med Pharmacol Sci. 2009;13(4):279-83.
De Luis, D. A., Izaola, O., Cuellar, L., Terroba, M. C., Martin, T., & Aller, R. (2009). High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trial. European Review for Medical and Pharmacological Sciences, 13(4), pp. 279-83.
De Luis DA, et al. High Dose of Arginine Enhanced Enteral Nutrition in Postsurgical Head and Neck Cancer Patients. a Randomized Clinical Trial. Eur Rev Med Pharmacol Sci. 2009;13(4):279-83. PubMed PMID: 19694342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trial. AU - De Luis,D A, AU - Izaola,O, AU - Cuellar,L, AU - Terroba,M C, AU - Martin,T, AU - Aller,R, PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2009/9/4/medline SP - 279 EP - 83 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 13 IS - 4 N2 - OBJECTIVE: Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using a higher dose of arginine (20 g per day) could improve nutritional variables. MATERIALS AND METHODS: A population of 72 patients with oral and laryngeal cancer was enrolled. At surgery patients were randomly allocated to two groups: a) patients were receiving an enteral diet supplements with arginine and fiber (group I); b) patients were receiving an isocaloric, isonitrogenous enteral formula (group II). RESULTS: No significant intergroup differences in the trend of the three serum proteins and lymphocytes were detected. Gastrointestinal tolerance (diarrhea) of both formulas was good (7.89% group I and 5.88% group II: ns). The postoperative infections complications were similar in both groups (23.6% group I and 20.6% group II: ns). Fistula was less frequent in enriched nutrition group (5.2% group I and 17.6% group II: p = 0.026). The length of postoperative stay was better 24.3 +/- 14 days in the immunonutrition group than 36.1 +/- 27 days in the control group (p = 0.036). CONCLUSIONS: Enriched formula improves local wound complications in postoperative head and neck cancer patients and decreases length of stay. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/19694342/High_dose_of_arginine_enhanced_enteral_nutrition_in_postsurgical_head_and_neck_cancer_patients__A_randomized_clinical_trial_ L2 - https://medlineplus.gov/headandneckcancer.html DB - PRIME DP - Unbound Medicine ER -