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Synthesis of functionalized isoquinolines via sequential cyclization/cross-coupling reactions.
J Comb Chem. 2009 Sep-Oct; 11(5):895-9.JC

Abstract

CuX(2)-mediated cyclization of 2-alkynylbenzaldehyde O-methyl oximes in N,N-dimethylacetamide (DMA) gave rise to 4-chloroisoquinolines in good yield, which underwent the palladium-catalyzed cross-coupling reactions of arylboronic acids subsequently to afford the functionalized isoquinolines.

Authors+Show Affiliations

Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19694423

Citation

Yu, Xingxin, and Jie Wu. "Synthesis of Functionalized Isoquinolines Via Sequential Cyclization/cross-coupling Reactions." Journal of Combinatorial Chemistry, vol. 11, no. 5, 2009, pp. 895-9.
Yu X, Wu J. Synthesis of functionalized isoquinolines via sequential cyclization/cross-coupling reactions. J Comb Chem. 2009;11(5):895-9.
Yu, X., & Wu, J. (2009). Synthesis of functionalized isoquinolines via sequential cyclization/cross-coupling reactions. Journal of Combinatorial Chemistry, 11(5), 895-9. https://doi.org/10.1021/cc900079s
Yu X, Wu J. Synthesis of Functionalized Isoquinolines Via Sequential Cyclization/cross-coupling Reactions. J Comb Chem. 2009 Sep-Oct;11(5):895-9. PubMed PMID: 19694423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of functionalized isoquinolines via sequential cyclization/cross-coupling reactions. AU - Yu,Xingxin, AU - Wu,Jie, PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2009/12/16/medline SP - 895 EP - 9 JF - Journal of combinatorial chemistry JO - J Comb Chem VL - 11 IS - 5 N2 - CuX(2)-mediated cyclization of 2-alkynylbenzaldehyde O-methyl oximes in N,N-dimethylacetamide (DMA) gave rise to 4-chloroisoquinolines in good yield, which underwent the palladium-catalyzed cross-coupling reactions of arylboronic acids subsequently to afford the functionalized isoquinolines. SN - 1520-4774 UR - https://www.unboundmedicine.com/medline/citation/19694423/Synthesis_of_functionalized_isoquinolines_via_sequential_cyclization/cross_coupling_reactions_ L2 - https://doi.org/10.1021/cc900079s DB - PRIME DP - Unbound Medicine ER -