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Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial.
J Sex Med. 2010 Jan; 7(1 Pt 1):156-65.JS

Abstract

INTRODUCTION

Overweight men with diabetes often report erectile dysfunction (ED), but few studies have examined effects of weight loss on this problem.

AIM

This study examined 1-year changes in erectile function (EF) in overweight/obese men with type 2 diabetes participating in the Look AHEAD (Action for Health in Diabetes) trial.

METHODS

Participants in Look AHEAD were randomly assigned to a control condition involving diabetes support and education (DSE) or to intensive lifestyle intervention (ILI) involving group and individual sessions to reduce weight and increase physical activity. Men from five of the clinical sites in Look AHEAD completed the International Index of Erectile Function (IIEF) at baseline (N = 372) and at 1 year (N = 306) (82%).

MAIN OUTCOME MEASURES

Changes in EF as reported on the EF subscale of the IIEF.

RESULTS

At 1 year, the ILI group lost a greater percent of initial body weight (9.9% vs. 0.6 %) and had greater improvements in fitness (22.7% vs. 4.6%) than DSE. EF improved more in ILI (17.3 +/- 7.6 at baseline; 18.6 +/- 8.1 at 1 year) than in DSE (18.3 +/- 7.6 at baseline; 18.4 +/- 8.0 at 1 year); P = 0.04 and P = 0.06 after adjusting for baseline differences. Using established norms for none (i.e., normal EF), and three grades (i.e., mild, moderate, and severe) ED, 8% of men in ILI reported a worsening of EF from baseline to 1 year, 70% stayed in the same category, and 22% reported improvements. In contrast, 20% of DSE reported worsening, 57% stayed in the same category, and 23% improved (P = 0.006).

CONCLUSION

In this sample of older overweight/obese diabetic men, weight loss intervention was mildly helpful in maintaining EF.

Authors+Show Affiliations

The Miriam Hospital/Brown Medical School, Providence, RI, USA. rwing@lifespan.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19694925

Citation

Wing, Rena R., et al. "Effects of Weight Loss Intervention On Erectile Function in Older Men With Type 2 Diabetes in the Look AHEAD Trial." The Journal of Sexual Medicine, vol. 7, no. 1 Pt 1, 2010, pp. 156-65.
Wing RR, Rosen RC, Fava JL, et al. Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial. J Sex Med. 2010;7(1 Pt 1):156-65.
Wing, R. R., Rosen, R. C., Fava, J. L., Bahnson, J., Brancati, F., Gendrano Iii, I. N., Kitabchi, A., Schneider, S. H., & Wadden, T. A. (2010). Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial. The Journal of Sexual Medicine, 7(1 Pt 1), 156-65. https://doi.org/10.1111/j.1743-6109.2009.01458.x
Wing RR, et al. Effects of Weight Loss Intervention On Erectile Function in Older Men With Type 2 Diabetes in the Look AHEAD Trial. J Sex Med. 2010;7(1 Pt 1):156-65. PubMed PMID: 19694925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial. AU - Wing,Rena R, AU - Rosen,Raymond C, AU - Fava,Joseph L, AU - Bahnson,Judy, AU - Brancati,Frederick, AU - Gendrano Iii,Isaias Noel C, AU - Kitabchi,Abbas, AU - Schneider,Stephen H, AU - Wadden,Thomas A, Y1 - 2009/08/17/ PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2010/4/9/medline SP - 156 EP - 65 JF - The journal of sexual medicine JO - J Sex Med VL - 7 IS - 1 Pt 1 N2 - INTRODUCTION: Overweight men with diabetes often report erectile dysfunction (ED), but few studies have examined effects of weight loss on this problem. AIM: This study examined 1-year changes in erectile function (EF) in overweight/obese men with type 2 diabetes participating in the Look AHEAD (Action for Health in Diabetes) trial. METHODS: Participants in Look AHEAD were randomly assigned to a control condition involving diabetes support and education (DSE) or to intensive lifestyle intervention (ILI) involving group and individual sessions to reduce weight and increase physical activity. Men from five of the clinical sites in Look AHEAD completed the International Index of Erectile Function (IIEF) at baseline (N = 372) and at 1 year (N = 306) (82%). MAIN OUTCOME MEASURES: Changes in EF as reported on the EF subscale of the IIEF. RESULTS: At 1 year, the ILI group lost a greater percent of initial body weight (9.9% vs. 0.6 %) and had greater improvements in fitness (22.7% vs. 4.6%) than DSE. EF improved more in ILI (17.3 +/- 7.6 at baseline; 18.6 +/- 8.1 at 1 year) than in DSE (18.3 +/- 7.6 at baseline; 18.4 +/- 8.0 at 1 year); P = 0.04 and P = 0.06 after adjusting for baseline differences. Using established norms for none (i.e., normal EF), and three grades (i.e., mild, moderate, and severe) ED, 8% of men in ILI reported a worsening of EF from baseline to 1 year, 70% stayed in the same category, and 22% reported improvements. In contrast, 20% of DSE reported worsening, 57% stayed in the same category, and 23% improved (P = 0.006). CONCLUSION: In this sample of older overweight/obese diabetic men, weight loss intervention was mildly helpful in maintaining EF. SN - 1743-6109 UR - https://www.unboundmedicine.com/medline/citation/19694925/Effects_of_weight_loss_intervention_on_erectile_function_in_older_men_with_type_2_diabetes_in_the_Look_AHEAD_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(15)32830-7 DB - PRIME DP - Unbound Medicine ER -