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Neurobehavioral impairment in children occupationally exposed to mixed organic solvents.
Neurotoxicology. 2009 Nov; 30(6):1166-71.N

Abstract

BACKGROUND

Our previous work has demonstrated adverse effects on neuropsychological and neurobehavioral function in solvent-exposed working children compared to non-exposed working and school children. The aim of this paper was to examine the dose-response relationships between neurobehavioral function and solvent exposure in children.

METHODS

We tested 120 male children aged 10-17 years (100 working solvent-exposed, 10 working children, 10 school children). Neurotoxic effects were assessed through a questionnaire and a selection of neurobehavioral tests. Workplace exposure to a mixture of solvents was measured using personal passive samplers.

RESULTS

Children with higher solvent exposure showed significantly higher reporting of neurotoxic symptoms (P=0.02). Importantly, multiple regression models revealed significant dose-response relationships, with higher cumulative exposure associated with poorer performance on the Choice Reaction Time, Symbol Digit, Continuous Performance, Digit Span and Grooved Pegboard tests.

CONCLUSIONS

This study provides the first empirical evidence of a dose-response association between exposure to solvents and neurobehavioral performance in working children. This finding implies that solvent-exposed working children are at high risk of developing neurobehavioral impairments. These impairments are likely to interfere with their capacity to respond quickly and safely to new demands and to learn new information.

Authors+Show Affiliations

Centre for Research, Evidence Management and Surveillance - Population Health, Sydney South West Area Health Service, Australia. basema.saddik@sswahs.nsw.gov.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19695285

Citation

Saddik, Basema, et al. "Neurobehavioral Impairment in Children Occupationally Exposed to Mixed Organic Solvents." Neurotoxicology, vol. 30, no. 6, 2009, pp. 1166-71.
Saddik B, Williamson A, Black D, et al. Neurobehavioral impairment in children occupationally exposed to mixed organic solvents. Neurotoxicology. 2009;30(6):1166-71.
Saddik, B., Williamson, A., Black, D., & Nuwayhid, I. (2009). Neurobehavioral impairment in children occupationally exposed to mixed organic solvents. Neurotoxicology, 30(6), 1166-71. https://doi.org/10.1016/j.neuro.2009.08.003
Saddik B, et al. Neurobehavioral Impairment in Children Occupationally Exposed to Mixed Organic Solvents. Neurotoxicology. 2009;30(6):1166-71. PubMed PMID: 19695285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurobehavioral impairment in children occupationally exposed to mixed organic solvents. AU - Saddik,Basema, AU - Williamson,Ann, AU - Black,Deborah, AU - Nuwayhid,Iman, Y1 - 2009/08/18/ PY - 2008/12/01/received PY - 2009/08/10/revised PY - 2009/08/11/accepted PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2010/3/10/medline SP - 1166 EP - 71 JF - Neurotoxicology JO - Neurotoxicology VL - 30 IS - 6 N2 - BACKGROUND: Our previous work has demonstrated adverse effects on neuropsychological and neurobehavioral function in solvent-exposed working children compared to non-exposed working and school children. The aim of this paper was to examine the dose-response relationships between neurobehavioral function and solvent exposure in children. METHODS: We tested 120 male children aged 10-17 years (100 working solvent-exposed, 10 working children, 10 school children). Neurotoxic effects were assessed through a questionnaire and a selection of neurobehavioral tests. Workplace exposure to a mixture of solvents was measured using personal passive samplers. RESULTS: Children with higher solvent exposure showed significantly higher reporting of neurotoxic symptoms (P=0.02). Importantly, multiple regression models revealed significant dose-response relationships, with higher cumulative exposure associated with poorer performance on the Choice Reaction Time, Symbol Digit, Continuous Performance, Digit Span and Grooved Pegboard tests. CONCLUSIONS: This study provides the first empirical evidence of a dose-response association between exposure to solvents and neurobehavioral performance in working children. This finding implies that solvent-exposed working children are at high risk of developing neurobehavioral impairments. These impairments are likely to interfere with their capacity to respond quickly and safely to new demands and to learn new information. SN - 1872-9711 UR - https://www.unboundmedicine.com/medline/citation/19695285/Neurobehavioral_impairment_in_children_occupationally_exposed_to_mixed_organic_solvents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(09)00174-0 DB - PRIME DP - Unbound Medicine ER -