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No correlation between time-linked plasma and CSF Abeta levels.
Neurochem Int 2009; 55(8):820-5NI

Abstract

Plasma beta-amyloid protein (Abeta) isoforms are considered potential biomarkers for Alzheimer's disease (AD) and dementia. The relation between plasma and cerebrospinal fluid (CSF) levels of Abeta isoforms remains unclear. In order to identify possible correlations between Abeta levels in plasma and CSF we determined Abeta levels in time-linked plasma and CSF samples. Abeta concentrations in plasma (Abeta(1-42) and Abeta(N-42)) and CSF (Abeta(1-42)) samples from 49 AD patients, 47 non-Alzheimer's disease dementia (NONAD) patients, 39 MCI patients and 29 controls were determined using a multi-parameter fluorimetric bead-based immunoassay using xMAP((R)) technology (for plasma) and a conventional single-parameter ELISA (for CSF). Plasma Abeta(1-42) concentrations did not correlate with CSF Abeta(1-42) concentrations in the total study population, or in the different diagnostic groups. No correlations between plasma Abeta(N-42) and CSF Abeta(1-42) levels were found either. The CSF/serum albumin index did not show any significant differences between AD, NONAD, MCI and controls. These results suggest that the Abeta levels in plasma are independent of the Abeta levels in CSF both in dementia and controls. The fact that CSF and plasma Abeta do not correlate in patients as well as controls and no significant differences in plasma Abeta(1-42) or Abeta(N-42) between patients and controls can be detected hampers the diagnostic utility of the plasma Abeta levels as biomarkers for dementia.

Authors+Show Affiliations

Laboratory of Neurochemistry and Behavior, Reference Center for Biological Markers of Memory Disorders, University of Antwerp, Antwerp, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19695299

Citation

Le Bastard, Nathalie, et al. "No Correlation Between Time-linked Plasma and CSF Abeta Levels." Neurochemistry International, vol. 55, no. 8, 2009, pp. 820-5.
Le Bastard N, Aerts L, Leurs J, et al. No correlation between time-linked plasma and CSF Abeta levels. Neurochem Int. 2009;55(8):820-5.
Le Bastard, N., Aerts, L., Leurs, J., Blomme, W., De Deyn, P. P., & Engelborghs, S. (2009). No correlation between time-linked plasma and CSF Abeta levels. Neurochemistry International, 55(8), pp. 820-5. doi:10.1016/j.neuint.2009.08.006.
Le Bastard N, et al. No Correlation Between Time-linked Plasma and CSF Abeta Levels. Neurochem Int. 2009;55(8):820-5. PubMed PMID: 19695299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No correlation between time-linked plasma and CSF Abeta levels. AU - Le Bastard,Nathalie, AU - Aerts,Laetitia, AU - Leurs,Judith, AU - Blomme,Walter, AU - De Deyn,Peter P, AU - Engelborghs,Sebastiaan, Y1 - 2009/08/18/ PY - 2009/07/01/received PY - 2009/08/04/revised PY - 2009/08/08/accepted PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2010/1/26/medline SP - 820 EP - 5 JF - Neurochemistry international JO - Neurochem. Int. VL - 55 IS - 8 N2 - Plasma beta-amyloid protein (Abeta) isoforms are considered potential biomarkers for Alzheimer's disease (AD) and dementia. The relation between plasma and cerebrospinal fluid (CSF) levels of Abeta isoforms remains unclear. In order to identify possible correlations between Abeta levels in plasma and CSF we determined Abeta levels in time-linked plasma and CSF samples. Abeta concentrations in plasma (Abeta(1-42) and Abeta(N-42)) and CSF (Abeta(1-42)) samples from 49 AD patients, 47 non-Alzheimer's disease dementia (NONAD) patients, 39 MCI patients and 29 controls were determined using a multi-parameter fluorimetric bead-based immunoassay using xMAP((R)) technology (for plasma) and a conventional single-parameter ELISA (for CSF). Plasma Abeta(1-42) concentrations did not correlate with CSF Abeta(1-42) concentrations in the total study population, or in the different diagnostic groups. No correlations between plasma Abeta(N-42) and CSF Abeta(1-42) levels were found either. The CSF/serum albumin index did not show any significant differences between AD, NONAD, MCI and controls. These results suggest that the Abeta levels in plasma are independent of the Abeta levels in CSF both in dementia and controls. The fact that CSF and plasma Abeta do not correlate in patients as well as controls and no significant differences in plasma Abeta(1-42) or Abeta(N-42) between patients and controls can be detected hampers the diagnostic utility of the plasma Abeta levels as biomarkers for dementia. SN - 1872-9754 UR - https://www.unboundmedicine.com/medline/citation/19695299/No_correlation_between_time_linked_plasma_and_CSF_Abeta_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-0186(09)00242-3 DB - PRIME DP - Unbound Medicine ER -