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Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses.

Abstract

It has been 40 years since the last influenza pandemic and it is generally considered that another could occur at any time. Recent introductions of influenza A viruses from avian sources into the human population have raised concerns that these viruses may be a source of a future pandemic strain. Therefore, there is a need to better understand the pathogenicity of avian influenza viruses for mammalian species so that we may be better able to predict the pandemic potential of such viruses and develop improved methods for their prevention and control. In this review, we describe the virulence of H5 and H7 avian influenza viruses in the mouse and ferret models. The use of these models is providing exciting new insights into the contribution of virus and host responses toward avian influenza viruses, virus tropism, and virus transmissibility. Identifying the role of individual viral gene products and mapping the molecular determinants that influence the severity of disease observed following avian influenza virus infection is dependent on the use of reliable animal models. As avian influenza viruses continue to cause human disease and death, animal pathogenesis studies identify avenues of investigation for novel preventative and therapeutic agents that could be effective in the event of a future pandemic.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

    , ,

    Source

    Advances in virus research 73: 2009 pg 55-97

    MeSH

    Animals
    Disease Models, Animal
    Disease Outbreaks
    Ducks
    Ferrets
    Host-Pathogen Interactions
    Humans
    Influenza A Virus, H5N1 Subtype
    Influenza A Virus, H7N7 Subtype
    Influenza in Birds
    Influenza, Human
    Mice
    Mice, Inbred BALB C
    Orthomyxoviridae Infections
    Virulence

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19695381

    Citation

    Belser, Jessica A., et al. "Use of Animal Models to Understand the Pandemic Potential of Highly Pathogenic Avian Influenza Viruses." Advances in Virus Research, vol. 73, 2009, pp. 55-97.
    Belser JA, Szretter KJ, Katz JM, et al. Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses. Adv Virus Res. 2009;73:55-97.
    Belser, J. A., Szretter, K. J., Katz, J. M., & Tumpey, T. M. (2009). Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses. Advances in Virus Research, 73, pp. 55-97. doi:10.1016/S0065-3527(09)73002-7.
    Belser JA, et al. Use of Animal Models to Understand the Pandemic Potential of Highly Pathogenic Avian Influenza Viruses. Adv Virus Res. 2009;73:55-97. PubMed PMID: 19695381.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses. AU - Belser,Jessica A, AU - Szretter,Kristy J, AU - Katz,Jacqueline M, AU - Tumpey,Terrence M, PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2009/10/27/medline SP - 55 EP - 97 JF - Advances in virus research JO - Adv. Virus Res. VL - 73 N2 - It has been 40 years since the last influenza pandemic and it is generally considered that another could occur at any time. Recent introductions of influenza A viruses from avian sources into the human population have raised concerns that these viruses may be a source of a future pandemic strain. Therefore, there is a need to better understand the pathogenicity of avian influenza viruses for mammalian species so that we may be better able to predict the pandemic potential of such viruses and develop improved methods for their prevention and control. In this review, we describe the virulence of H5 and H7 avian influenza viruses in the mouse and ferret models. The use of these models is providing exciting new insights into the contribution of virus and host responses toward avian influenza viruses, virus tropism, and virus transmissibility. Identifying the role of individual viral gene products and mapping the molecular determinants that influence the severity of disease observed following avian influenza virus infection is dependent on the use of reliable animal models. As avian influenza viruses continue to cause human disease and death, animal pathogenesis studies identify avenues of investigation for novel preventative and therapeutic agents that could be effective in the event of a future pandemic. SN - 1557-8399 UR - https://www.unboundmedicine.com/medline/citation/19695381/Use_of_animal_models_to_understand_the_pandemic_potential_of_highly_pathogenic_avian_influenza_viruses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0065-3527(09)73002-7 DB - PRIME DP - Unbound Medicine ER -