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Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori.
J Hum Genet 2009; 54(10):557-63JH

Abstract

This study investigated the association between glutathione S-transferases (GST) polymorphisms and immunoglobin G (IgG) titer levels in serum against Helicobacter pylori (H. pylori). Out of a total 300 healthy subjects seropositive for H. pylori, we analyzed the relationship between 15 single-nucleotide polymorphisms (SNPs), namely two in GST-mu2 (GST-M2), five in GST-mu3 (GST-M3), four in GST-pi1 (GST-P1) and four in GST-theta2 (GST-T2), and IgG antibody titer levels in serum against cytotoxin-associated gene A (CagA) and the surface antigen of H. pylori (Hp), as well as the levels of pepsinogen I (PGI). Titer levels were classified by tertile. The age-sex adjusted odds ratios (ORs) and 95% confidence intervals (CIs) in the middle and low titer groups were calculated using a polytomous logistic regression model, with the high titer group considered as control. Results for GST-M3 showed a significant association between SNPs, CagA and Hp titers. In addition, the AA genotype (high enzyme activity) from SNP rs7483 (Val224Ile) in GST-M3 showed a significantly low risk for being in the low titer group (OR: 0.48, 95% CI: 0.27-0.86 and OR: 0.46, 95% CI: 0.26-0.83 for CagA and Hp, respectively). Furthermore, the AA genotype from the rs7483 SNP showed significantly (P<0.05) higher PGI levels than did the genotypes harboring a G allele (mean (s.d.)=66.9 (32.0) and 59.1 (30.7) microg ml(-1) for AA and AG+GG, respectively). Our results suggest that GST-M3 polymorphisms are associated with levels of IgG titer in serum against H. pylori. GST-M3 activity is possibly involved in protection against mucosal atrophy caused by H. pylori as the levels of IgG titer and PGI are linked to mucosal status.

Authors+Show Affiliations

Department of Hygiene and Preventive Medicine, School of Medicine, Showa University, Shinagawa-ku, Tokyo, Japan. tatemichi@med.showa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19696791

Citation

Tatemichi, Masayuki, et al. "Association Between Polymorphisms in Glutathione S-transferase Mu3 and IgG Titer Levels in Serum Against Helicobacter Pylori." Journal of Human Genetics, vol. 54, no. 10, 2009, pp. 557-63.
Tatemichi M, Iwasaki M, Sasazuki S, et al. Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. J Hum Genet. 2009;54(10):557-63.
Tatemichi, M., Iwasaki, M., Sasazuki, S., & Tsugane, S. (2009). Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. Journal of Human Genetics, 54(10), pp. 557-63. doi:10.1038/jhg.2009.77.
Tatemichi M, et al. Association Between Polymorphisms in Glutathione S-transferase Mu3 and IgG Titer Levels in Serum Against Helicobacter Pylori. J Hum Genet. 2009;54(10):557-63. PubMed PMID: 19696791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between polymorphisms in glutathione S-transferase Mu3 and IgG titer levels in serum against Helicobacter pylori. AU - Tatemichi,Masayuki, AU - Iwasaki,Motoki, AU - Sasazuki,Shizuka, AU - Tsugane,Shoichiro, Y1 - 2009/08/21/ PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2009/12/30/medline SP - 557 EP - 63 JF - Journal of human genetics JO - J. Hum. Genet. VL - 54 IS - 10 N2 - This study investigated the association between glutathione S-transferases (GST) polymorphisms and immunoglobin G (IgG) titer levels in serum against Helicobacter pylori (H. pylori). Out of a total 300 healthy subjects seropositive for H. pylori, we analyzed the relationship between 15 single-nucleotide polymorphisms (SNPs), namely two in GST-mu2 (GST-M2), five in GST-mu3 (GST-M3), four in GST-pi1 (GST-P1) and four in GST-theta2 (GST-T2), and IgG antibody titer levels in serum against cytotoxin-associated gene A (CagA) and the surface antigen of H. pylori (Hp), as well as the levels of pepsinogen I (PGI). Titer levels were classified by tertile. The age-sex adjusted odds ratios (ORs) and 95% confidence intervals (CIs) in the middle and low titer groups were calculated using a polytomous logistic regression model, with the high titer group considered as control. Results for GST-M3 showed a significant association between SNPs, CagA and Hp titers. In addition, the AA genotype (high enzyme activity) from SNP rs7483 (Val224Ile) in GST-M3 showed a significantly low risk for being in the low titer group (OR: 0.48, 95% CI: 0.27-0.86 and OR: 0.46, 95% CI: 0.26-0.83 for CagA and Hp, respectively). Furthermore, the AA genotype from the rs7483 SNP showed significantly (P<0.05) higher PGI levels than did the genotypes harboring a G allele (mean (s.d.)=66.9 (32.0) and 59.1 (30.7) microg ml(-1) for AA and AG+GG, respectively). Our results suggest that GST-M3 polymorphisms are associated with levels of IgG titer in serum against H. pylori. GST-M3 activity is possibly involved in protection against mucosal atrophy caused by H. pylori as the levels of IgG titer and PGI are linked to mucosal status. SN - 1435-232X UR - https://www.unboundmedicine.com/medline/citation/19696791/Association_between_polymorphisms_in_glutathione_S_transferase_Mu3_and_IgG_titer_levels_in_serum_against_Helicobacter_pylori_ DB - PRIME DP - Unbound Medicine ER -