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Chemical composition and antifungal activity of the essential oils of Lavandula pedunculata (Miller) Cav.
Chem Biodivers. 2009 Aug; 6(8):1283-92.CB

Abstract

The chemical composition and antifungal activity of the essential oils of Lavandula pedunculata (Miller) Cav., harvested in North and Central Portugal, were investigated. The essential oils were isolated by hydrodistillation and analyzed by GC and GC/MS. The minimal-inhibitory concentration (MIC) and the minimal-lethal concentration (MLC) of the essential oils and of their major constituents were used to evaluate the antifungal activity against different strains of fungi involved in candidosis, dematophytosis, and aspergillosis. The oils were characterized by a high percentage of oxygenated monoterpenes, the main compounds being 1,8-cineole (2.4-55.5%), fenchone (1.3-59.7%), and camphor (3.6-48.0%). Statistical analysis differentiated the essential oils into two main types, one characterized by the predominance of fenchone and the other one by the predominance of 1,8-cineole. Within the 1,8-cineole chemotype, two subgroups were well-defined taking into account the percentages of camphor. A significant antifungal activity of the oils was found against dermatophyte strains. The essential oil with the highest content of camphor was the most active with MIC and MLC values ranging from 0.32-0.64 microl/ml.

Authors+Show Affiliations

Department of Botany, Faculty of Sciences and Technology, University of Coimbra, Calçada Martim de Freitas, Coimbra.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19697345

Citation

Zuzarte, Monica, et al. "Chemical Composition and Antifungal Activity of the Essential Oils of Lavandula Pedunculata (Miller) Cav." Chemistry & Biodiversity, vol. 6, no. 8, 2009, pp. 1283-92.
Zuzarte M, Gonçalves MJ, Cavaleiro C, et al. Chemical composition and antifungal activity of the essential oils of Lavandula pedunculata (Miller) Cav. Chem Biodivers. 2009;6(8):1283-92.
Zuzarte, M., Gonçalves, M. J., Cavaleiro, C., Dinis, A. M., Canhoto, J. M., & Salgueiro, L. R. (2009). Chemical composition and antifungal activity of the essential oils of Lavandula pedunculata (Miller) Cav. Chemistry & Biodiversity, 6(8), 1283-92. https://doi.org/10.1002/cbdv.200800170
Zuzarte M, et al. Chemical Composition and Antifungal Activity of the Essential Oils of Lavandula Pedunculata (Miller) Cav. Chem Biodivers. 2009;6(8):1283-92. PubMed PMID: 19697345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and antifungal activity of the essential oils of Lavandula pedunculata (Miller) Cav. AU - Zuzarte,Monica, AU - Gonçalves,Maria J, AU - Cavaleiro,Carlos, AU - Dinis,Augusto M, AU - Canhoto,Jorge M, AU - Salgueiro,Lígia R, PY - 2009/8/22/entrez PY - 2009/8/22/pubmed PY - 2009/11/17/medline SP - 1283 EP - 92 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 6 IS - 8 N2 - The chemical composition and antifungal activity of the essential oils of Lavandula pedunculata (Miller) Cav., harvested in North and Central Portugal, were investigated. The essential oils were isolated by hydrodistillation and analyzed by GC and GC/MS. The minimal-inhibitory concentration (MIC) and the minimal-lethal concentration (MLC) of the essential oils and of their major constituents were used to evaluate the antifungal activity against different strains of fungi involved in candidosis, dematophytosis, and aspergillosis. The oils were characterized by a high percentage of oxygenated monoterpenes, the main compounds being 1,8-cineole (2.4-55.5%), fenchone (1.3-59.7%), and camphor (3.6-48.0%). Statistical analysis differentiated the essential oils into two main types, one characterized by the predominance of fenchone and the other one by the predominance of 1,8-cineole. Within the 1,8-cineole chemotype, two subgroups were well-defined taking into account the percentages of camphor. A significant antifungal activity of the oils was found against dermatophyte strains. The essential oil with the highest content of camphor was the most active with MIC and MLC values ranging from 0.32-0.64 microl/ml. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/19697345/Chemical_composition_and_antifungal_activity_of_the_essential_oils_of_Lavandula_pedunculata__Miller__Cav_ DB - PRIME DP - Unbound Medicine ER -