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Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder.
Brain Res. 2009 Dec 15; 1303:195-206.BR

Abstract

Structural and functional alterations of the putamen have been reported in patients with attention deficit hyperactivity disorder (ADHD), but the functional relationships between this area and other brain regions are seldom explored. In the present study, seed-based correlation analyses were performed in the resting-state functional magnetic resonance imaging (fMRI) data to examine the differences in functional connectivity of the putamen between medication-naïve children with ADHD and normal children. Positive functional connectivity with the putamen-ROIs was seen in bilateral sensorimotor area, prefrontal cortex, insula, superior temporal gyrus and subcortical regions and negative functional connectivity was located in bilateral parietal and occipital cortex as well as clusters in the frontal, middle temporal cortex and cerebellum. Group comparison showed that decreases in functional connectivity with the putamen-ROIs were observed in ADHD relative to the controls, except for the right globus pallidus/thalamus, which showed increased positive connectivity with left putamen-ROI. For children with ADHD, areas exhibiting decreased positive functional connectivity with left putamen-ROI were seen in right frontal and limbic regions, and regions showing decreased negative connectivity with the putamen-ROIs were observed in areas belonging to the default mode network (for left putamen-ROI, including right cerebellum and right temporal lobe; for right putamen-ROI, including left cerebellum and right precuneus). The above results suggest that abnormal functional relationships between the putamen and the cortical-striatal-thalamic circuits as well as the default mode network may underlie the pathological basis of ADHD.

Authors+Show Affiliations

Institute of Mental Health, Peking University, Beijing 100191, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19699190

Citation

Cao, Xiaohua, et al. "Abnormal Resting-state Functional Connectivity Patterns of the Putamen in Medication-naïve Children With Attention Deficit Hyperactivity Disorder." Brain Research, vol. 1303, 2009, pp. 195-206.
Cao X, Cao Q, Long X, et al. Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder. Brain Res. 2009;1303:195-206.
Cao, X., Cao, Q., Long, X., Sun, L., Sui, M., Zhu, C., Zuo, X., Zang, Y., & Wang, Y. (2009). Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder. Brain Research, 1303, 195-206. https://doi.org/10.1016/j.brainres.2009.08.029
Cao X, et al. Abnormal Resting-state Functional Connectivity Patterns of the Putamen in Medication-naïve Children With Attention Deficit Hyperactivity Disorder. Brain Res. 2009 Dec 15;1303:195-206. PubMed PMID: 19699190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal resting-state functional connectivity patterns of the putamen in medication-naïve children with attention deficit hyperactivity disorder. AU - Cao,Xiaohua, AU - Cao,Qingjiu, AU - Long,Xiangyu, AU - Sun,Li, AU - Sui,Manqiu, AU - Zhu,Chaozhe, AU - Zuo,Xinian, AU - Zang,Yufeng, AU - Wang,Yufeng, Y1 - 2009/08/20/ PY - 2009/03/08/received PY - 2009/07/20/revised PY - 2009/08/10/accepted PY - 2009/8/25/entrez PY - 2009/8/25/pubmed PY - 2010/7/14/medline SP - 195 EP - 206 JF - Brain research JO - Brain Res. VL - 1303 N2 - Structural and functional alterations of the putamen have been reported in patients with attention deficit hyperactivity disorder (ADHD), but the functional relationships between this area and other brain regions are seldom explored. In the present study, seed-based correlation analyses were performed in the resting-state functional magnetic resonance imaging (fMRI) data to examine the differences in functional connectivity of the putamen between medication-naïve children with ADHD and normal children. Positive functional connectivity with the putamen-ROIs was seen in bilateral sensorimotor area, prefrontal cortex, insula, superior temporal gyrus and subcortical regions and negative functional connectivity was located in bilateral parietal and occipital cortex as well as clusters in the frontal, middle temporal cortex and cerebellum. Group comparison showed that decreases in functional connectivity with the putamen-ROIs were observed in ADHD relative to the controls, except for the right globus pallidus/thalamus, which showed increased positive connectivity with left putamen-ROI. For children with ADHD, areas exhibiting decreased positive functional connectivity with left putamen-ROI were seen in right frontal and limbic regions, and regions showing decreased negative connectivity with the putamen-ROIs were observed in areas belonging to the default mode network (for left putamen-ROI, including right cerebellum and right temporal lobe; for right putamen-ROI, including left cerebellum and right precuneus). The above results suggest that abnormal functional relationships between the putamen and the cortical-striatal-thalamic circuits as well as the default mode network may underlie the pathological basis of ADHD. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19699190/Abnormal_resting_state_functional_connectivity_patterns_of_the_putamen_in_medication_naïve_children_with_attention_deficit_hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)01712-0 DB - PRIME DP - Unbound Medicine ER -