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Coincidence of neurokinin 1 receptor with the vesicular glutamate transporter 3 (VGLUT3) in the rat forebrain.
Neurosci Lett 2009; 464(3):188-92NL

Abstract

The third vesicular glutamate transporter (VGLUT3) is expressed in a subset of cholinergic and GABAergic neurons in the forebrain. In this study the distribution of VGLUT3 was mapped in relation to the receptor for substance P, neurokinin 1 (NK1), which has been independently reported within cholinergic and GABAergic neurons in a similar distribution. Dual immunofluorescence labeling techniques were used, sometimes in combination with triple labeling for the vesicular acetylcholine transporter (VAChT), to identify cholinergic cells. Virtually all cells immunolabeled for VGLUT3 in the nucleus accumbens core and shell regions, ventral pallidum, olfactory tubercle and caudate putamen were cholinergic and also contained immunolabeling for the NK1 receptor. In the hippocampal formation where VGLUT3 has been described in GABAergic neurons, colocalization between NK1 and VGLUT3 was also common but less complete. Cells double labeled for NK1 and VGLUT3 were most prevalent in stratum radiatum in the CA1 subfield. In the habenula VGLUT3 was also found within NK1 receptor immunolabeled neurons. However, there were some areas where neurons containing these two proteins were separate populations including the cerebral cortex and median raphe nucleus. These results reveal a trend for VGLUT3 to localize within neurons containing the NK1 receptor in several areas of the forebrain.

Authors+Show Affiliations

Department of Anesthesiology, Perioperative and Pain Medicine, Children's Hospital, Boston, MA 02115, United States. Kathryn.Commons@childrens.harvard.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19699779

Citation

Commons, K G., and M R. Serock. "Coincidence of Neurokinin 1 Receptor With the Vesicular Glutamate Transporter 3 (VGLUT3) in the Rat Forebrain." Neuroscience Letters, vol. 464, no. 3, 2009, pp. 188-92.
Commons KG, Serock MR. Coincidence of neurokinin 1 receptor with the vesicular glutamate transporter 3 (VGLUT3) in the rat forebrain. Neurosci Lett. 2009;464(3):188-92.
Commons, K. G., & Serock, M. R. (2009). Coincidence of neurokinin 1 receptor with the vesicular glutamate transporter 3 (VGLUT3) in the rat forebrain. Neuroscience Letters, 464(3), pp. 188-92. doi:10.1016/j.neulet.2009.08.042.
Commons KG, Serock MR. Coincidence of Neurokinin 1 Receptor With the Vesicular Glutamate Transporter 3 (VGLUT3) in the Rat Forebrain. Neurosci Lett. 2009 Oct 30;464(3):188-92. PubMed PMID: 19699779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coincidence of neurokinin 1 receptor with the vesicular glutamate transporter 3 (VGLUT3) in the rat forebrain. AU - Commons,K G, AU - Serock,M R, Y1 - 2009/08/21/ PY - 2009/06/12/received PY - 2009/08/13/revised PY - 2009/08/15/accepted PY - 2009/8/25/entrez PY - 2009/8/25/pubmed PY - 2009/11/10/medline SP - 188 EP - 92 JF - Neuroscience letters JO - Neurosci. Lett. VL - 464 IS - 3 N2 - The third vesicular glutamate transporter (VGLUT3) is expressed in a subset of cholinergic and GABAergic neurons in the forebrain. In this study the distribution of VGLUT3 was mapped in relation to the receptor for substance P, neurokinin 1 (NK1), which has been independently reported within cholinergic and GABAergic neurons in a similar distribution. Dual immunofluorescence labeling techniques were used, sometimes in combination with triple labeling for the vesicular acetylcholine transporter (VAChT), to identify cholinergic cells. Virtually all cells immunolabeled for VGLUT3 in the nucleus accumbens core and shell regions, ventral pallidum, olfactory tubercle and caudate putamen were cholinergic and also contained immunolabeling for the NK1 receptor. In the hippocampal formation where VGLUT3 has been described in GABAergic neurons, colocalization between NK1 and VGLUT3 was also common but less complete. Cells double labeled for NK1 and VGLUT3 were most prevalent in stratum radiatum in the CA1 subfield. In the habenula VGLUT3 was also found within NK1 receptor immunolabeled neurons. However, there were some areas where neurons containing these two proteins were separate populations including the cerebral cortex and median raphe nucleus. These results reveal a trend for VGLUT3 to localize within neurons containing the NK1 receptor in several areas of the forebrain. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/19699779/Coincidence_of_neurokinin_1_receptor_with_the_vesicular_glutamate_transporter_3__VGLUT3__in_the_rat_forebrain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(09)01122-7 DB - PRIME DP - Unbound Medicine ER -