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Visual acuity outcomes after cataract surgery in patients with age-related macular degeneration: age-related eye disease study report no. 27.
Ophthalmology. 2009 Nov; 116(11):2093-100.O

Abstract

OBJECTIVE

To evaluate visual acuity outcomes after cataract surgery in patients with varying degrees of age-related macular degeneration (AMD).

DESIGN

Cohort study.

PARTICIPANTS

A total of 4757 participants enrolled in the Age-Related Eye Disease Study (AREDS), a prospective, multicenter, epidemiological study of the clinical course of cataract and AMD and a randomized controlled trial of antioxidants and minerals.

METHODS

Standardized lens and fundus photographs, performed at baseline and annual visits, were graded by a centralized reading center using standardized protocols for severity of AMD and lens opacities. History of cataract surgery was obtained every 6 months. Analyses were conducted using multivariate logistic regression.

MAIN OUTCOME MEASURE

The change in best-corrected visual acuity (BCVA) after cataract surgery compared with preoperative BCVA.

RESULTS

Visual acuity results were analyzed for 1939 eyes that had cataract surgery during AREDS. The mean time from cataract surgery to measurement of postoperative BCVA was 6.9 months. After adjustment for age at surgery, gender, type, and severity of cataract, the mean change in visual acuity at the next study visit after the cataract surgery was as follows: Eyes without AMD gained 8.4 letters of acuity (P<0.0001), eyes with mild AMD gained 6.1 letters of visual acuity (P<0.0001), eyes with moderate AMD gained 3.9 letters (P<0.0001), and eyes with advanced AMD gained 1.9 letters (P = 0.04). The statistically significant gain in visual acuity after cataract surgery was maintained an average of 1.4 years after cataract surgery.

CONCLUSIONS

On average, participants with varying severity of AMD benefited from cataract surgery with an increase in visual acuity postoperatively. This average gain in visual acuity persisted for at least 18 months.

Authors+Show Affiliations

Clinical Trials Branch, Division of Epidemiology and Clinical Applications, National Eye Institute/National Institutes of Health, Bethesda, Maryland 20892-1204, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

19700198

Citation

Forooghian, Farzin, et al. "Visual Acuity Outcomes After Cataract Surgery in Patients With Age-related Macular Degeneration: Age-related Eye Disease Study Report No. 27." Ophthalmology, vol. 116, no. 11, 2009, pp. 2093-100.
Forooghian F, Agrón E, Clemons TE, et al. Visual acuity outcomes after cataract surgery in patients with age-related macular degeneration: age-related eye disease study report no. 27. Ophthalmology. 2009;116(11):2093-100.
Forooghian, F., Agrón, E., Clemons, T. E., Ferris, F. L., & Chew, E. Y. (2009). Visual acuity outcomes after cataract surgery in patients with age-related macular degeneration: age-related eye disease study report no. 27. Ophthalmology, 116(11), 2093-100. https://doi.org/10.1016/j.ophtha.2009.04.033
Forooghian F, et al. Visual Acuity Outcomes After Cataract Surgery in Patients With Age-related Macular Degeneration: Age-related Eye Disease Study Report No. 27. Ophthalmology. 2009;116(11):2093-100. PubMed PMID: 19700198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visual acuity outcomes after cataract surgery in patients with age-related macular degeneration: age-related eye disease study report no. 27. AU - Forooghian,Farzin, AU - Agrón,Elvira, AU - Clemons,Traci E, AU - Ferris,Frederick L,3rd AU - Chew,Emily Y, AU - ,, Y1 - 2009/08/22/ PY - 2008/12/24/received PY - 2009/02/21/revised PY - 2009/04/17/accepted PY - 2009/8/25/entrez PY - 2009/8/25/pubmed PY - 2009/11/13/medline SP - 2093 EP - 100 JF - Ophthalmology JO - Ophthalmology VL - 116 IS - 11 N2 - OBJECTIVE: To evaluate visual acuity outcomes after cataract surgery in patients with varying degrees of age-related macular degeneration (AMD). DESIGN: Cohort study. PARTICIPANTS: A total of 4757 participants enrolled in the Age-Related Eye Disease Study (AREDS), a prospective, multicenter, epidemiological study of the clinical course of cataract and AMD and a randomized controlled trial of antioxidants and minerals. METHODS: Standardized lens and fundus photographs, performed at baseline and annual visits, were graded by a centralized reading center using standardized protocols for severity of AMD and lens opacities. History of cataract surgery was obtained every 6 months. Analyses were conducted using multivariate logistic regression. MAIN OUTCOME MEASURE: The change in best-corrected visual acuity (BCVA) after cataract surgery compared with preoperative BCVA. RESULTS: Visual acuity results were analyzed for 1939 eyes that had cataract surgery during AREDS. The mean time from cataract surgery to measurement of postoperative BCVA was 6.9 months. After adjustment for age at surgery, gender, type, and severity of cataract, the mean change in visual acuity at the next study visit after the cataract surgery was as follows: Eyes without AMD gained 8.4 letters of acuity (P<0.0001), eyes with mild AMD gained 6.1 letters of visual acuity (P<0.0001), eyes with moderate AMD gained 3.9 letters (P<0.0001), and eyes with advanced AMD gained 1.9 letters (P = 0.04). The statistically significant gain in visual acuity after cataract surgery was maintained an average of 1.4 years after cataract surgery. CONCLUSIONS: On average, participants with varying severity of AMD benefited from cataract surgery with an increase in visual acuity postoperatively. This average gain in visual acuity persisted for at least 18 months. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/19700198/Visual_acuity_outcomes_after_cataract_surgery_in_patients_with_age_related_macular_degeneration:_age_related_eye_disease_study_report_no__27_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(09)00419-9 DB - PRIME DP - Unbound Medicine ER -