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The role of nutrition in Alzheimer's disease: epidemiological evidence.

Abstract

The prevalence of Alzheimer's disease (AD) increases exponentially with age but there is limited knowledge of the modifiable risk factors for AD. However, there is growing evidence for possible dietary risk factors in the development of AD and cognitive decline with age, such as antioxidant nutrients, fish, dietary fats, and B-vitamins. Numerous animal and laboratory studies have shown that antioxidant nutrients can protect the brain from oxidative and inflammatory damage, but there are limited data available from epidemiological studies. There is more substantial epidemiological evidence from a number of recent studies that demonstrate a protective role of omega-3 fatty acids, such as docosahexaenoic acid, in AD and cognitive decline. This review will focus on epidemiological evidence investigating the relationship between nutrition and AD, focusing particularly on the roles of dietary fats and antioxidants.

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  • Authors+Show Affiliations

    Section of Nutritional Epidemiology and Nutrition, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA. mmorris@rush.edu

    Source

    European journal of neurology 16 Suppl 1: 2009 Sep pg 1-7

    MeSH

    Alzheimer Disease
    Animals
    Antioxidants
    Cytoprotection
    Dietary Fats
    Fatty Acids, Omega-3
    Humans
    Hypercholesterolemia
    Malnutrition
    Oxidative Stress
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    19703213

    Citation

    Morris, M C.. "The Role of Nutrition in Alzheimer's Disease: Epidemiological Evidence." European Journal of Neurology, vol. 16 Suppl 1, 2009, pp. 1-7.
    Morris MC. The role of nutrition in Alzheimer's disease: epidemiological evidence. Eur J Neurol. 2009;16 Suppl 1:1-7.
    Morris, M. C. (2009). The role of nutrition in Alzheimer's disease: epidemiological evidence. European Journal of Neurology, 16 Suppl 1, pp. 1-7. doi:10.1111/j.1468-1331.2009.02735.x.
    Morris MC. The Role of Nutrition in Alzheimer's Disease: Epidemiological Evidence. Eur J Neurol. 2009;16 Suppl 1:1-7. PubMed PMID: 19703213.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The role of nutrition in Alzheimer's disease: epidemiological evidence. A1 - Morris,M C, PY - 2009/8/26/entrez PY - 2009/8/26/pubmed PY - 2009/12/16/medline SP - 1 EP - 7 JF - European journal of neurology JO - Eur. J. Neurol. VL - 16 Suppl 1 N2 - The prevalence of Alzheimer's disease (AD) increases exponentially with age but there is limited knowledge of the modifiable risk factors for AD. However, there is growing evidence for possible dietary risk factors in the development of AD and cognitive decline with age, such as antioxidant nutrients, fish, dietary fats, and B-vitamins. Numerous animal and laboratory studies have shown that antioxidant nutrients can protect the brain from oxidative and inflammatory damage, but there are limited data available from epidemiological studies. There is more substantial epidemiological evidence from a number of recent studies that demonstrate a protective role of omega-3 fatty acids, such as docosahexaenoic acid, in AD and cognitive decline. This review will focus on epidemiological evidence investigating the relationship between nutrition and AD, focusing particularly on the roles of dietary fats and antioxidants. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/19703213/The_role_of_nutrition_in_Alzheimer's_disease:_epidemiological_evidence_ L2 - https://doi.org/10.1111/j.1468-1331.2009.02735.x DB - PRIME DP - Unbound Medicine ER -