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Antioxidants and periodontitis in 60-70-year-old men.
J Clin Periodontol 2009; 36(10):843-9JC

Abstract

OBJECTIVE

The aim was to investigate the association between periodontal health and the serum levels of various antioxidants including carotenoids, retinol and vitamin E in a homogenous group of Western European men.

MATERIALS AND METHODS

A representative sample of 1258 men aged 60-70 years, drawn from the population of Northern Ireland, was examined between 2001 and 2003. Each participant had six or more teeth, completed a questionnaire and underwent a clinical periodontal examination. Serum lipid-soluble antioxidant levels were measured by high-performance liquid chromatography with diode array detection. Multivariable analysis was carried out using logistic regression with adjustment for possible confounders. Models were constructed using two measures of periodontal status (low- and high-threshold periodontitis) as dependent variables and the fifths of each antioxidant as a predictor variable.

RESULTS

The levels of alpha- and beta-carotene, beta-cryptoxanthin and zeaxanthin were highly significantly lower in the men with low-threshold periodontitis (p<0.001). These carotenoids were also significantly lower in high-threshold periodontitis. There were no significant differences in the levels of lutein, lycopene, alpha- and gamma-tocopherol or retinol in relation to periodontitis. In fully adjusted models, there was an inverse relationship between a number of carotenoids (alpha- and beta-carotene and beta-cryptoxanthin) and low-threshold periodontitis. beta-Carotene and beta-cryptoxanthin were the only antioxidants that were associated with an increased risk of high-threshold severe periodontitis. The adjusted odds ratio for high-threshold periodontitis in the lowest fifth relative to the highest fifth of beta-cryptoxanthin was 4.02 (p=0.003).

CONCLUSION

It is concluded that low serum levels of a number of carotenoids, in particular beta-cryptoxanthin and beta-carotene, were associated with an increased prevalence of periodontitis in this homogenous group of 60-70-year-old Western European men.

Authors+Show Affiliations

Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, Northern Ireland, UK. g.linden@qub.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19703237

Citation

Linden, Gerard J., et al. "Antioxidants and Periodontitis in 60-70-year-old Men." Journal of Clinical Periodontology, vol. 36, no. 10, 2009, pp. 843-9.
Linden GJ, McClean KM, Woodside JV, et al. Antioxidants and periodontitis in 60-70-year-old men. J Clin Periodontol. 2009;36(10):843-9.
Linden, G. J., McClean, K. M., Woodside, J. V., Patterson, C. C., Evans, A., Young, I. S., & Kee, F. (2009). Antioxidants and periodontitis in 60-70-year-old men. Journal of Clinical Periodontology, 36(10), pp. 843-9. doi:10.1111/j.1600-051X.2009.01468.x.
Linden GJ, et al. Antioxidants and Periodontitis in 60-70-year-old Men. J Clin Periodontol. 2009;36(10):843-9. PubMed PMID: 19703237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidants and periodontitis in 60-70-year-old men. AU - Linden,Gerard J, AU - McClean,Kathy M, AU - Woodside,Jayne V, AU - Patterson,Chris C, AU - Evans,Alun, AU - Young,Ian S, AU - Kee,Frank, Y1 - 2009/08/23/ PY - 2009/8/26/entrez PY - 2009/8/26/pubmed PY - 2009/12/16/medline SP - 843 EP - 9 JF - Journal of clinical periodontology JO - J. Clin. Periodontol. VL - 36 IS - 10 N2 - OBJECTIVE: The aim was to investigate the association between periodontal health and the serum levels of various antioxidants including carotenoids, retinol and vitamin E in a homogenous group of Western European men. MATERIALS AND METHODS: A representative sample of 1258 men aged 60-70 years, drawn from the population of Northern Ireland, was examined between 2001 and 2003. Each participant had six or more teeth, completed a questionnaire and underwent a clinical periodontal examination. Serum lipid-soluble antioxidant levels were measured by high-performance liquid chromatography with diode array detection. Multivariable analysis was carried out using logistic regression with adjustment for possible confounders. Models were constructed using two measures of periodontal status (low- and high-threshold periodontitis) as dependent variables and the fifths of each antioxidant as a predictor variable. RESULTS: The levels of alpha- and beta-carotene, beta-cryptoxanthin and zeaxanthin were highly significantly lower in the men with low-threshold periodontitis (p<0.001). These carotenoids were also significantly lower in high-threshold periodontitis. There were no significant differences in the levels of lutein, lycopene, alpha- and gamma-tocopherol or retinol in relation to periodontitis. In fully adjusted models, there was an inverse relationship between a number of carotenoids (alpha- and beta-carotene and beta-cryptoxanthin) and low-threshold periodontitis. beta-Carotene and beta-cryptoxanthin were the only antioxidants that were associated with an increased risk of high-threshold severe periodontitis. The adjusted odds ratio for high-threshold periodontitis in the lowest fifth relative to the highest fifth of beta-cryptoxanthin was 4.02 (p=0.003). CONCLUSION: It is concluded that low serum levels of a number of carotenoids, in particular beta-cryptoxanthin and beta-carotene, were associated with an increased prevalence of periodontitis in this homogenous group of 60-70-year-old Western European men. SN - 1600-051X UR - https://www.unboundmedicine.com/medline/citation/19703237/Antioxidants_and_periodontitis_in_60_70_year_old_men_ L2 - https://doi.org/10.1111/j.1600-051X.2009.01468.x DB - PRIME DP - Unbound Medicine ER -