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Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy.

Abstract

We aimed to determine the effect of supplementation with coenzyme Q10 on conventional therapy of children with cardiac failure due to idiopathic dilated cardiomyopathy. In a prospective, randomized, double-blinded, placebo-controlled trial, we randomized 38 patients younger than 18 years with idiopathic dilated cardiomyopathy to receive either coenzyme Q10, chosen for 17 patients, or placebo, administered in the remaining 21. Echocardiographic systolic and diastolic function parameters were determined for every patient at baseline, and after 6 months of supplementation. The index score for cardiac failure in children as established in New York was used for assessing the functional class of the patients. After 6 months supplementation, 10 patients randomized to receive coenzyme Q10 showed improvements in the grading of diastolic function, this being significantly more than that achieved by those randomized to the placebo group (p value = 0.011). The mean score for the index of cardiac failure index for those receiving coenzyme Q10 was also lower than the control group (p value = 0.024).Our results, therefore, indicate that administration of coenzyme Q10 is useful in ameliorating cardiac failure in patients with idiopathic dilated cardiomyopathy through its significant effect on improving diastolic function.

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  • Authors+Show Affiliations

    ,

    Department of Pediatric Cardiology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

    , , ,

    Source

    Cardiology in the young 19:5 2009 Sep pg 501-6

    MeSH

    Adolescent
    Cardiomyopathy, Dilated
    Child
    Child, Preschool
    Double-Blind Method
    Heart Failure
    Humans
    Infant
    Prospective Studies
    Ubiquinone
    Vitamins

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    19703336

    Citation

    Kocharian, Armen, et al. "Coenzyme Q10 Improves Diastolic Function in Children With Idiopathic Dilated Cardiomyopathy." Cardiology in the Young, vol. 19, no. 5, 2009, pp. 501-6.
    Kocharian A, Shabanian R, Rafiei-Khorgami M, et al. Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy. Cardiol Young. 2009;19(5):501-6.
    Kocharian, A., Shabanian, R., Rafiei-Khorgami, M., Kiani, A., & Heidari-Bateni, G. (2009). Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy. Cardiology in the Young, 19(5), pp. 501-6. doi:10.1017/S1047951109990795.
    Kocharian A, et al. Coenzyme Q10 Improves Diastolic Function in Children With Idiopathic Dilated Cardiomyopathy. Cardiol Young. 2009;19(5):501-6. PubMed PMID: 19703336.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Coenzyme Q10 improves diastolic function in children with idiopathic dilated cardiomyopathy. AU - Kocharian,Armen, AU - Shabanian,Reza, AU - Rafiei-Khorgami,Mohammad, AU - Kiani,Abdolrazagh, AU - Heidari-Bateni,Giv, Y1 - 2009/08/25/ PY - 2009/8/26/entrez PY - 2009/8/26/pubmed PY - 2010/2/3/medline SP - 501 EP - 6 JF - Cardiology in the young JO - Cardiol Young VL - 19 IS - 5 N2 - We aimed to determine the effect of supplementation with coenzyme Q10 on conventional therapy of children with cardiac failure due to idiopathic dilated cardiomyopathy. In a prospective, randomized, double-blinded, placebo-controlled trial, we randomized 38 patients younger than 18 years with idiopathic dilated cardiomyopathy to receive either coenzyme Q10, chosen for 17 patients, or placebo, administered in the remaining 21. Echocardiographic systolic and diastolic function parameters were determined for every patient at baseline, and after 6 months of supplementation. The index score for cardiac failure in children as established in New York was used for assessing the functional class of the patients. After 6 months supplementation, 10 patients randomized to receive coenzyme Q10 showed improvements in the grading of diastolic function, this being significantly more than that achieved by those randomized to the placebo group (p value = 0.011). The mean score for the index of cardiac failure index for those receiving coenzyme Q10 was also lower than the control group (p value = 0.024).Our results, therefore, indicate that administration of coenzyme Q10 is useful in ameliorating cardiac failure in patients with idiopathic dilated cardiomyopathy through its significant effect on improving diastolic function. SN - 1467-1107 UR - https://www.unboundmedicine.com/medline/citation/19703336/Coenzyme_Q10_improves_diastolic_function_in_children_with_idiopathic_dilated_cardiomyopathy_ L2 - https://www.cambridge.org/core/product/identifier/S1047951109990795/type/journal_article DB - PRIME DP - Unbound Medicine ER -