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Evaluation of anti-inflammatory potential of Chloranthus erectus (Buch.-Ham.) Verd. leaf extract in rats.
J Ethnopharmacol. 2009 Nov 12; 126(2):371-4.JE

Abstract

AIM OF THE STUDY

Chloranthus erectus (Buch.-Ham.) Verdcourt (Chloranthaceae) is a shrub native to tropical and temperate zone of Eastern Himalaya of India and South-East Asia and have traditionally been used as a folklore medicine to treat localised swelling, joint pain, skin inflammation, fever and bodyache. In this study, an attempt has been made to demonstrate the anti-inflammatory activity of methanol extract obtained from Chloranthus erectus leaves (MECEL) in acute, sub-acute and chronic mouse models.

MATERIALS AND METHODS

Inflammation in the hind paw of Wistar albino rat was induced by carrageenan, histamine and serotonin, and tissue granuloma pouch was induced by cotton pellet method. Anti-inflammatory drug-phenylbutazone was used as standard drug for comparison.

RESULTS

In acute carrageenan-induced rat hind paw edema, oral administration of MECEL at 200 mg/kg produced significant inhibition of edema by 38.34% (p < 0.01) while the histamine- and serotonin-induced sub-acute model, the inhibition of paw edema reached 52.54% (p < 0.001) and 25.5% (p < 0.01), respectively. In a 7-day study, MECEL at 20 and 50 mg/kg produced significant suppression of cotton pellet-induced tissue granuloma formation in rats.

CONCLUSIONS

This preliminary study revealed that the methanol extract of Chloranthus erectus exhibited significant anti-inflammatory activity in the tested models, and may provide the scientific rationale for its popular folk medicine as anti-inflammatory agent.

Authors+Show Affiliations

Pharmacognosy Research Laboratory, Department of Botany, Rajiv Gandhi University, Rono Hills, Itanagar 791112, Arunachal Pradesh, India. huitag2008rgu@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19703538

Citation

Tag, Hui, et al. "Evaluation of Anti-inflammatory Potential of Chloranthus Erectus (Buch.-Ham.) Verd. Leaf Extract in Rats." Journal of Ethnopharmacology, vol. 126, no. 2, 2009, pp. 371-4.
Tag H, Namsa ND, Das AK, et al. Evaluation of anti-inflammatory potential of Chloranthus erectus (Buch.-Ham.) Verd. leaf extract in rats. J Ethnopharmacol. 2009;126(2):371-4.
Tag, H., Namsa, N. D., Das, A. K., Kalita, P., & Mandal, S. C. (2009). Evaluation of anti-inflammatory potential of Chloranthus erectus (Buch.-Ham.) Verd. leaf extract in rats. Journal of Ethnopharmacology, 126(2), 371-4. https://doi.org/10.1016/j.jep.2009.08.015
Tag H, et al. Evaluation of Anti-inflammatory Potential of Chloranthus Erectus (Buch.-Ham.) Verd. Leaf Extract in Rats. J Ethnopharmacol. 2009 Nov 12;126(2):371-4. PubMed PMID: 19703538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of anti-inflammatory potential of Chloranthus erectus (Buch.-Ham.) Verd. leaf extract in rats. AU - Tag,Hui, AU - Namsa,Nima D, AU - Das,A K, AU - Kalita,P, AU - Mandal,S C, Y1 - 2009/08/22/ PY - 2008/12/08/received PY - 2009/07/15/revised PY - 2009/08/13/accepted PY - 2009/8/26/entrez PY - 2009/8/26/pubmed PY - 2010/3/24/medline SP - 371 EP - 4 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 126 IS - 2 N2 - AIM OF THE STUDY: Chloranthus erectus (Buch.-Ham.) Verdcourt (Chloranthaceae) is a shrub native to tropical and temperate zone of Eastern Himalaya of India and South-East Asia and have traditionally been used as a folklore medicine to treat localised swelling, joint pain, skin inflammation, fever and bodyache. In this study, an attempt has been made to demonstrate the anti-inflammatory activity of methanol extract obtained from Chloranthus erectus leaves (MECEL) in acute, sub-acute and chronic mouse models. MATERIALS AND METHODS: Inflammation in the hind paw of Wistar albino rat was induced by carrageenan, histamine and serotonin, and tissue granuloma pouch was induced by cotton pellet method. Anti-inflammatory drug-phenylbutazone was used as standard drug for comparison. RESULTS: In acute carrageenan-induced rat hind paw edema, oral administration of MECEL at 200 mg/kg produced significant inhibition of edema by 38.34% (p < 0.01) while the histamine- and serotonin-induced sub-acute model, the inhibition of paw edema reached 52.54% (p < 0.001) and 25.5% (p < 0.01), respectively. In a 7-day study, MECEL at 20 and 50 mg/kg produced significant suppression of cotton pellet-induced tissue granuloma formation in rats. CONCLUSIONS: This preliminary study revealed that the methanol extract of Chloranthus erectus exhibited significant anti-inflammatory activity in the tested models, and may provide the scientific rationale for its popular folk medicine as anti-inflammatory agent. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/19703538/Evaluation_of_anti_inflammatory_potential_of_Chloranthus_erectus__Buch__Ham___Verd__leaf_extract_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(09)00510-8 DB - PRIME DP - Unbound Medicine ER -