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Dietary fatty acids and predementia syndromes.

Abstract

An increasing body of epidemiological evidence suggests that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD). Furthermore, a reduction of risk for cognitive decline and mild cognitive impairment (MCI) has been found in population samples with elevated fish consumption, and high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE epsilon4 carriers. These data, together with epidemiological evidence, support the idea that n-3 PUFA may play a role in maintaining adequate cognitive functioning in predementia syndromes, but not when the AD process has already taken over. Therefore, at present, no definitive dietary recommendations on fish and unsaturated fatty acids consumption, or lower intake of saturated fat, in relation to the risk for dementia and cognitive decline are possible.

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  • Authors+Show Affiliations

    ,

    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy. v.solfrizzi@geriatria.uniba.it

    , , , , , ,

    Source

    TheScientificWorldJournal 9: 2009 Aug 11 pg 792-810

    MeSH

    Cross-Sectional Studies
    Dementia
    Dietary Fats
    Dietary Supplements
    Fatty Acids
    Humans
    Longitudinal Studies
    Seafood

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    19705039

    Citation

    Solfrizzi, Vincenzo, et al. "Dietary Fatty Acids and Predementia Syndromes." TheScientificWorldJournal, vol. 9, 2009, pp. 792-810.
    Solfrizzi V, Frisardi V, Capurso C, et al. Dietary fatty acids and predementia syndromes. ScientificWorldJournal. 2009;9:792-810.
    Solfrizzi, V., Frisardi, V., Capurso, C., D'Introno, A., Colacicco, A. M., Vendemiale, G., ... Panza, F. (2009). Dietary fatty acids and predementia syndromes. TheScientificWorldJournal, 9, pp. 792-810. doi:10.1100/tsw.2009.82.
    Solfrizzi V, et al. Dietary Fatty Acids and Predementia Syndromes. ScientificWorldJournal. 2009 Aug 11;9:792-810. PubMed PMID: 19705039.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fatty acids and predementia syndromes. AU - Solfrizzi,Vincenzo, AU - Frisardi,Vincenza, AU - Capurso,Cristiano, AU - D'Introno,Alessia, AU - Colacicco,Anna M, AU - Vendemiale,Gianluigi, AU - Capurso,Antonio, AU - Panza,Francesco, Y1 - 2009/08/11/ PY - 2009/8/26/entrez PY - 2009/8/26/pubmed PY - 2009/11/10/medline SP - 792 EP - 810 JF - TheScientificWorldJournal JO - ScientificWorldJournal VL - 9 N2 - An increasing body of epidemiological evidence suggests that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD). Furthermore, a reduction of risk for cognitive decline and mild cognitive impairment (MCI) has been found in population samples with elevated fish consumption, and high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE epsilon4 carriers. These data, together with epidemiological evidence, support the idea that n-3 PUFA may play a role in maintaining adequate cognitive functioning in predementia syndromes, but not when the AD process has already taken over. Therefore, at present, no definitive dietary recommendations on fish and unsaturated fatty acids consumption, or lower intake of saturated fat, in relation to the risk for dementia and cognitive decline are possible. SN - 1537-744X UR - https://www.unboundmedicine.com/medline/citation/19705039/Dietary_fatty_acids_and_predementia_syndromes_ L2 - https://dx.doi.org/10.1100/tsw.2009.82 DB - PRIME DP - Unbound Medicine ER -