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Dietary fatty acids and predementia syndromes.
ScientificWorldJournal 2009; 9:792-810S

Abstract

An increasing body of epidemiological evidence suggests that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD). Furthermore, a reduction of risk for cognitive decline and mild cognitive impairment (MCI) has been found in population samples with elevated fish consumption, and high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE epsilon4 carriers. These data, together with epidemiological evidence, support the idea that n-3 PUFA may play a role in maintaining adequate cognitive functioning in predementia syndromes, but not when the AD process has already taken over. Therefore, at present, no definitive dietary recommendations on fish and unsaturated fatty acids consumption, or lower intake of saturated fat, in relation to the risk for dementia and cognitive decline are possible.

Authors+Show Affiliations

Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy. v.solfrizzi@geriatria.uniba.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19705039

Citation

Solfrizzi, Vincenzo, et al. "Dietary Fatty Acids and Predementia Syndromes." TheScientificWorldJournal, vol. 9, 2009, pp. 792-810.
Solfrizzi V, Frisardi V, Capurso C, et al. Dietary fatty acids and predementia syndromes. ScientificWorldJournal. 2009;9:792-810.
Solfrizzi, V., Frisardi, V., Capurso, C., D'Introno, A., Colacicco, A. M., Vendemiale, G., ... Panza, F. (2009). Dietary fatty acids and predementia syndromes. TheScientificWorldJournal, 9, pp. 792-810. doi:10.1100/tsw.2009.82.
Solfrizzi V, et al. Dietary Fatty Acids and Predementia Syndromes. ScientificWorldJournal. 2009 Aug 11;9:792-810. PubMed PMID: 19705039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fatty acids and predementia syndromes. AU - Solfrizzi,Vincenzo, AU - Frisardi,Vincenza, AU - Capurso,Cristiano, AU - D'Introno,Alessia, AU - Colacicco,Anna M, AU - Vendemiale,Gianluigi, AU - Capurso,Antonio, AU - Panza,Francesco, Y1 - 2009/08/11/ PY - 2009/8/26/entrez PY - 2009/8/26/pubmed PY - 2009/11/10/medline SP - 792 EP - 810 JF - TheScientificWorldJournal JO - ScientificWorldJournal VL - 9 N2 - An increasing body of epidemiological evidence suggests that elevated saturated fatty acids (SFA) could have negative effects on age-related cognitive decline (ARCD). Furthermore, a reduction of risk for cognitive decline and mild cognitive impairment (MCI) has been found in population samples with elevated fish consumption, and high intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. However, recent findings from clinical trials with n-3 PUFA supplementation showed efficacy on depressive symptoms in non-apolipoprotein E (APOE) epsilon4 carriers, and on cognitive symptoms only in very mild Alzheimer's disease (AD) subgroups, MCI patients, and cognitively unimpaired non-APOE epsilon4 carriers. These data, together with epidemiological evidence, support the idea that n-3 PUFA may play a role in maintaining adequate cognitive functioning in predementia syndromes, but not when the AD process has already taken over. Therefore, at present, no definitive dietary recommendations on fish and unsaturated fatty acids consumption, or lower intake of saturated fat, in relation to the risk for dementia and cognitive decline are possible. SN - 1537-744X UR - https://www.unboundmedicine.com/medline/citation/19705039/Dietary_fatty_acids_and_predementia_syndromes_ L2 - https://dx.doi.org/10.1100/tsw.2009.82 DB - PRIME DP - Unbound Medicine ER -