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Multi-residue analysis of eight thioamphetamine designer drugs in human urine by liquid chromatography/tandem mass spectrometry.
Rapid Commun Mass Spectrom. 2009 Oct; 23(19):3051-6.RC

Abstract

An analytical procedure for the simultaneous determination in human urine of several thioamphetamine designer drugs (2C-T and ALEPH series) is reported. The quantitative analysis was performed by liquid chromatography/tandem mass spectrometry and has been fully validated. The mass spectrometer was operated in positive-ion, selected reaction monitoring (SRM) mode. In order to minimize interferences with matrix components and to preconcentrate target analytes, solid-phase extraction was introduced in the method as a clean-up step. The entire method was validated for selectivity, linearity, precision and accuracy. The method turned out to be specific, sensitive, and reliable for the analysis of amphetamine derivatives in urine samples. The calibration curves were linear over the concentration range of 1 to 100 ng mL(-1) for all drugs with correlation coefficients that exceeded 0.996. The lower limits of detection (LODs) and quantification (LOQs) ranged from 1.2 to 4.9 ng mL(-1) and from 3.2 to 9.6 ng mL(-1), respectively.

Authors+Show Affiliations

Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23, 07100 Sassari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19705383

Citation

Nieddu, Maria, et al. "Multi-residue Analysis of Eight Thioamphetamine Designer Drugs in Human Urine By Liquid Chromatography/tandem Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 23, no. 19, 2009, pp. 3051-6.
Nieddu M, Boatto G, Pirisi MA, et al. Multi-residue analysis of eight thioamphetamine designer drugs in human urine by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2009;23(19):3051-6.
Nieddu, M., Boatto, G., Pirisi, M. A., & Baralla, E. (2009). Multi-residue analysis of eight thioamphetamine designer drugs in human urine by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 23(19), 3051-6. https://doi.org/10.1002/rcm.4219
Nieddu M, et al. Multi-residue Analysis of Eight Thioamphetamine Designer Drugs in Human Urine By Liquid Chromatography/tandem Mass Spectrometry. Rapid Commun Mass Spectrom. 2009;23(19):3051-6. PubMed PMID: 19705383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multi-residue analysis of eight thioamphetamine designer drugs in human urine by liquid chromatography/tandem mass spectrometry. AU - Nieddu,Maria, AU - Boatto,Gianpiero, AU - Pirisi,Maria Antonietta, AU - Baralla,Elena, PY - 2009/8/26/entrez PY - 2009/8/26/pubmed PY - 2009/10/29/medline SP - 3051 EP - 6 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 23 IS - 19 N2 - An analytical procedure for the simultaneous determination in human urine of several thioamphetamine designer drugs (2C-T and ALEPH series) is reported. The quantitative analysis was performed by liquid chromatography/tandem mass spectrometry and has been fully validated. The mass spectrometer was operated in positive-ion, selected reaction monitoring (SRM) mode. In order to minimize interferences with matrix components and to preconcentrate target analytes, solid-phase extraction was introduced in the method as a clean-up step. The entire method was validated for selectivity, linearity, precision and accuracy. The method turned out to be specific, sensitive, and reliable for the analysis of amphetamine derivatives in urine samples. The calibration curves were linear over the concentration range of 1 to 100 ng mL(-1) for all drugs with correlation coefficients that exceeded 0.996. The lower limits of detection (LODs) and quantification (LOQs) ranged from 1.2 to 4.9 ng mL(-1) and from 3.2 to 9.6 ng mL(-1), respectively. SN - 1097-0231 UR - https://www.unboundmedicine.com/medline/citation/19705383/Multi_residue_analysis_of_eight_thioamphetamine_designer_drugs_in_human_urine_by_liquid_chromatography/tandem_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.4219 DB - PRIME DP - Unbound Medicine ER -