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Frequent hemorrhagic lesions in cerebral toxoplasmosis in AIDS patients.
J Neuroimaging 2009; 19(2):169-73JN

Abstract

Cerebral toxoplasmosis is a frequent complication in immunosuppressed patients such as AIDS (acquired immunodeficiency syndrome). Frequently, lesions are located deep in the brain which are inaccessible for biopsy making rapid diagnosis dependent on accurate interpretation of neuroimaging findings. The commonest cranial CT findings reported in toxoplasmosis are ring enhancing hypodense lesions in basal ganglia or cortical gray matter. Hemorrhage has only rarely been described and is usually seen following antitoxoplasma treatment. We reviewed the records of 11 AIDS patients with cerebral toxoplasmosis and found multiple hemorrhagic cerebral, cerebellar, or brain stem lesions in 7 of 11 patients. Six patients had hemorrhage at the time of initial clinical presentation and one developed hemorrhage following 2 weeks of antitoxoplasma treatment. We conclude that hemorrhagic lesions are frequently found on cranial MRI scans in cerebral toxoplasmosis. AIDS patients presenting with hemorrhagic cerebral lesions should be considered for a trial of presumptive antitoxoplasma treatment.

Authors+Show Affiliations

SUNY Downstate Medical Center, Department of Neurology, New York, New York 11203, USA. Sbhagavati@downstate.eduNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19705517

Citation

Bhagavati, Satyakam, and Jan Choi. "Frequent Hemorrhagic Lesions in Cerebral Toxoplasmosis in AIDS Patients." Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, vol. 19, no. 2, 2009, pp. 169-73.
Bhagavati S, Choi J. Frequent hemorrhagic lesions in cerebral toxoplasmosis in AIDS patients. J Neuroimaging. 2009;19(2):169-73.
Bhagavati, S., & Choi, J. (2009). Frequent hemorrhagic lesions in cerebral toxoplasmosis in AIDS patients. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging, 19(2), pp. 169-73.
Bhagavati S, Choi J. Frequent Hemorrhagic Lesions in Cerebral Toxoplasmosis in AIDS Patients. J Neuroimaging. 2009;19(2):169-73. PubMed PMID: 19705517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequent hemorrhagic lesions in cerebral toxoplasmosis in AIDS patients. AU - Bhagavati,Satyakam, AU - Choi,Jan, PY - 2009/8/26/entrez PY - 2009/8/26/pubmed PY - 2009/10/29/medline SP - 169 EP - 73 JF - Journal of neuroimaging : official journal of the American Society of Neuroimaging JO - J Neuroimaging VL - 19 IS - 2 N2 - Cerebral toxoplasmosis is a frequent complication in immunosuppressed patients such as AIDS (acquired immunodeficiency syndrome). Frequently, lesions are located deep in the brain which are inaccessible for biopsy making rapid diagnosis dependent on accurate interpretation of neuroimaging findings. The commonest cranial CT findings reported in toxoplasmosis are ring enhancing hypodense lesions in basal ganglia or cortical gray matter. Hemorrhage has only rarely been described and is usually seen following antitoxoplasma treatment. We reviewed the records of 11 AIDS patients with cerebral toxoplasmosis and found multiple hemorrhagic cerebral, cerebellar, or brain stem lesions in 7 of 11 patients. Six patients had hemorrhage at the time of initial clinical presentation and one developed hemorrhage following 2 weeks of antitoxoplasma treatment. We conclude that hemorrhagic lesions are frequently found on cranial MRI scans in cerebral toxoplasmosis. AIDS patients presenting with hemorrhagic cerebral lesions should be considered for a trial of presumptive antitoxoplasma treatment. SN - 1552-6569 UR - https://www.unboundmedicine.com/medline/citation/19705517/Frequent_hemorrhagic_lesions_in_cerebral_toxoplasmosis_in_AIDS_patients_ L2 - https://doi.org/10.1111/j.1552-6569.2008.00274.x DB - PRIME DP - Unbound Medicine ER -