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Risk of ovarian cancer in women with symptoms in primary care: population based case-control study.
BMJ 2009; 339:b2998BMJ

Abstract

OBJECTIVE

To identify and quantify symptoms of ovarian cancer in women in primary care.

DESIGN

Case-control study, with coding of participants' primary care records for one year before diagnosis.

SETTING

39 general practices in Devon, England.

PARTICIPANTS

212 women aged over 40 with a diagnosis of primary ovarian cancer, 2000-7; 1060 controls matched by age and general practice.

MAIN OUTCOME MEASURES

Odds ratios and positive predictive values for symptoms from conditional logistic regression analyses.

RESULTS

Seven symptoms were associated with ovarian cancer in multivariable analysis. The univariable positive predictive values and multivariable odds ratios (with 95% confidence intervals) for these were 2.5% (1.2% to 5.9%) and 240 (46 to 1200) for abdominal distension; 0.5% (0.2% to 0.9%) and 24 (9.3 to 64) for postmenopausal bleeding; 0.6% (0.3% to 1.0%) and 17 (6.1 to 50) for loss of appetite; 0.2% (0.1% to 0.3%) and 16 (5.6 to 48) for increased urinary frequency; 0.3% (0.2% to 0.3%) and 12 (6.1 to 22) for abdominal pain; 0.2% (0.1% to 0.4%) and 7.6 (2.5 to 23) for rectal bleeding; and 0.3% (0.2% to 0.6%) and 5.3 (1.8 to 16) for abdominal bloating. In 181 (85%) cases and 164 (15%) controls at least one of these seven symptoms was reported to primary care before diagnosis. After exclusion of symptoms reported in the 180 days before diagnosis, abdominal distension, urinary frequency, and abdominal pain remained independently associated with a diagnosis of ovarian cancer.

CONCLUSIONS

Women with ovarian cancer usually have symptoms and report them to primary care, sometimes months before diagnosis. This study provides an evidence base for selection of patients for investigation, both for clinicians and for developers of guidelines.

Authors+Show Affiliations

NIHR School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA, UK. w.hamilton@bristol.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19706933

Citation

Hamilton, William, et al. "Risk of Ovarian Cancer in Women With Symptoms in Primary Care: Population Based Case-control Study." BMJ (Clinical Research Ed.), vol. 339, 2009, pp. b2998.
Hamilton W, Peters TJ, Bankhead C, et al. Risk of ovarian cancer in women with symptoms in primary care: population based case-control study. BMJ. 2009;339:b2998.
Hamilton, W., Peters, T. J., Bankhead, C., & Sharp, D. (2009). Risk of ovarian cancer in women with symptoms in primary care: population based case-control study. BMJ (Clinical Research Ed.), 339, pp. b2998. doi:10.1136/bmj.b2998.
Hamilton W, et al. Risk of Ovarian Cancer in Women With Symptoms in Primary Care: Population Based Case-control Study. BMJ. 2009 Aug 25;339:b2998. PubMed PMID: 19706933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of ovarian cancer in women with symptoms in primary care: population based case-control study. AU - Hamilton,William, AU - Peters,Tim J, AU - Bankhead,Clare, AU - Sharp,Deborah, Y1 - 2009/08/25/ PY - 2009/8/27/entrez PY - 2009/8/27/pubmed PY - 2009/9/11/medline SP - b2998 EP - b2998 JF - BMJ (Clinical research ed.) JO - BMJ VL - 339 N2 - OBJECTIVE: To identify and quantify symptoms of ovarian cancer in women in primary care. DESIGN: Case-control study, with coding of participants' primary care records for one year before diagnosis. SETTING: 39 general practices in Devon, England. PARTICIPANTS: 212 women aged over 40 with a diagnosis of primary ovarian cancer, 2000-7; 1060 controls matched by age and general practice. MAIN OUTCOME MEASURES: Odds ratios and positive predictive values for symptoms from conditional logistic regression analyses. RESULTS: Seven symptoms were associated with ovarian cancer in multivariable analysis. The univariable positive predictive values and multivariable odds ratios (with 95% confidence intervals) for these were 2.5% (1.2% to 5.9%) and 240 (46 to 1200) for abdominal distension; 0.5% (0.2% to 0.9%) and 24 (9.3 to 64) for postmenopausal bleeding; 0.6% (0.3% to 1.0%) and 17 (6.1 to 50) for loss of appetite; 0.2% (0.1% to 0.3%) and 16 (5.6 to 48) for increased urinary frequency; 0.3% (0.2% to 0.3%) and 12 (6.1 to 22) for abdominal pain; 0.2% (0.1% to 0.4%) and 7.6 (2.5 to 23) for rectal bleeding; and 0.3% (0.2% to 0.6%) and 5.3 (1.8 to 16) for abdominal bloating. In 181 (85%) cases and 164 (15%) controls at least one of these seven symptoms was reported to primary care before diagnosis. After exclusion of symptoms reported in the 180 days before diagnosis, abdominal distension, urinary frequency, and abdominal pain remained independently associated with a diagnosis of ovarian cancer. CONCLUSIONS: Women with ovarian cancer usually have symptoms and report them to primary care, sometimes months before diagnosis. This study provides an evidence base for selection of patients for investigation, both for clinicians and for developers of guidelines. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/19706933/Risk_of_ovarian_cancer_in_women_with_symptoms_in_primary_care:_population_based_case_control_study_ L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=19706933 DB - PRIME DP - Unbound Medicine ER -