Tags

Type your tag names separated by a space and hit enter

Placebo-controlled clinical trial of use of 10% hydrogen peroxide whitening strips for medication-induced xerostomia.
Gerontology. 2009; 55(5):511-6.G

Abstract

OBJECTIVE

A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of peroxide-containing strip-based tooth whitening among subjects with medication-induced hyposalivation.

METHODS

Eligibility for this tooth whitening study was limited to dentate adults taking xerogenic medications with an unstimulated salivary flow < or = 0.2 ml/min. After giving informed consent, 42 subjects were randomized using a 2:1 ratio to 10% hydrogen peroxide whitening strips (Crest Whitestrips Premium) or placebo strips without peroxide. Strips were used for 30 min twice daily for a 14-day period. Usage was unsupervised, and only the maxillary arch was treated. On days 8 and 15, efficacy was assessed from standard digital images of the anterior dentition and quantified using the Cielab color system, while safety was assessed from interviews and clinical examinations.

RESULTS

At day 8, the peroxide group experienced significant (p < 0.001) color improvement relative to baseline and placebo. Adjusted means +/- standard errors for yellowness reduction were -1.65 +/- 0.115 units for the peroxide group and -0.32 +/- 0.170 units for the placebo group. For the increase in lightness, adjusted means +/- standard errors on day 8 were 1.53 +/- 0.130 units for the peroxide group and 0.37 +/- 0.191 units for the controls. Continued strip use through day 15 yielded incremental color improvement for the peroxide group. Mild and transient tooth sensitivity represented the most common adverse events. No subject discontinued treatment due to a product-related adverse event.

CONCLUSION

Twice daily use of 10% hydrogen peroxide whitening strips by adults with medication-induced xerostomia was well tolerated, with significant tooth color improvement evident within 7 days.

Authors+Show Affiliations

Tufts University School of Dental Medicine, Boston, MA 02111, USA. athena.papas@tufts.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19707010

Citation

Papas, Athena S., et al. "Placebo-controlled Clinical Trial of Use of 10% Hydrogen Peroxide Whitening Strips for Medication-induced Xerostomia." Gerontology, vol. 55, no. 5, 2009, pp. 511-6.
Papas AS, Kugel G, Singh M, et al. Placebo-controlled clinical trial of use of 10% hydrogen peroxide whitening strips for medication-induced xerostomia. Gerontology. 2009;55(5):511-6.
Papas, A. S., Kugel, G., Singh, M., Barker, M. L., & Gerlach, R. W. (2009). Placebo-controlled clinical trial of use of 10% hydrogen peroxide whitening strips for medication-induced xerostomia. Gerontology, 55(5), 511-6. https://doi.org/10.1159/000235815
Papas AS, et al. Placebo-controlled Clinical Trial of Use of 10% Hydrogen Peroxide Whitening Strips for Medication-induced Xerostomia. Gerontology. 2009;55(5):511-6. PubMed PMID: 19707010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placebo-controlled clinical trial of use of 10% hydrogen peroxide whitening strips for medication-induced xerostomia. AU - Papas,Athena S, AU - Kugel,Gerard, AU - Singh,Mabi, AU - Barker,Matthew L, AU - Gerlach,Robert W, Y1 - 2009/08/25/ PY - 2007/08/09/received PY - 2008/07/10/accepted PY - 2009/8/27/entrez PY - 2009/8/27/pubmed PY - 2009/12/16/medline SP - 511 EP - 6 JF - Gerontology JO - Gerontology VL - 55 IS - 5 N2 - OBJECTIVE: A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of peroxide-containing strip-based tooth whitening among subjects with medication-induced hyposalivation. METHODS: Eligibility for this tooth whitening study was limited to dentate adults taking xerogenic medications with an unstimulated salivary flow < or = 0.2 ml/min. After giving informed consent, 42 subjects were randomized using a 2:1 ratio to 10% hydrogen peroxide whitening strips (Crest Whitestrips Premium) or placebo strips without peroxide. Strips were used for 30 min twice daily for a 14-day period. Usage was unsupervised, and only the maxillary arch was treated. On days 8 and 15, efficacy was assessed from standard digital images of the anterior dentition and quantified using the Cielab color system, while safety was assessed from interviews and clinical examinations. RESULTS: At day 8, the peroxide group experienced significant (p < 0.001) color improvement relative to baseline and placebo. Adjusted means +/- standard errors for yellowness reduction were -1.65 +/- 0.115 units for the peroxide group and -0.32 +/- 0.170 units for the placebo group. For the increase in lightness, adjusted means +/- standard errors on day 8 were 1.53 +/- 0.130 units for the peroxide group and 0.37 +/- 0.191 units for the controls. Continued strip use through day 15 yielded incremental color improvement for the peroxide group. Mild and transient tooth sensitivity represented the most common adverse events. No subject discontinued treatment due to a product-related adverse event. CONCLUSION: Twice daily use of 10% hydrogen peroxide whitening strips by adults with medication-induced xerostomia was well tolerated, with significant tooth color improvement evident within 7 days. SN - 1423-0003 UR - https://www.unboundmedicine.com/medline/citation/19707010/Placebo_controlled_clinical_trial_of_use_of_10_hydrogen_peroxide_whitening_strips_for_medication_induced_xerostomia_ DB - PRIME DP - Unbound Medicine ER -