Tags

Type your tag names separated by a space and hit enter

Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer.

Abstract

Evidence suggests that nutrients involved in one-carbon metabolism are implicated in ovarian cancer etiology. No studies have evaluated the role of choline, and that of its metabolite, betaine. We prospectively examined the relationship between the intake of these nutrients and ovarian cancer risk among 159 957 participants from the Nurses' Health Study (NHS) and NHSII. The average nutrient intake was assessed every 2-4 years beginning in 1984 (for NHS) and in 1991 (for NHSII). With up to 22 years of follow-up per cohort, 526 incident cases of ovarian cancer were diagnosed. There were no associations between total choline, betaine, as well as choline plus betaine intake and ovarian cancer risk (for example, relative risk, top vs bottom quintile of choline=0.98; 95% confidence interval: 0.73-1.31; P(trend)=0.81). Results did not vary by alcohol consumption, folate intake or after the exclusion of cases diagnosed during the 4-year period after dietary assessment. These data provide little evidence for a role of these nutrients in ovarian cancer etiology.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. nhjok@channing.harvard.edu

    ,

    Source

    MeSH

    Adult
    Betaine
    Choline
    Diet
    Epithelium
    Female
    Humans
    Middle Aged
    Ovarian Neoplasms
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19707229

    Citation

    Kotsopoulos, J, et al. "Dietary Betaine and Choline Intake Are Not Associated With Risk of Epithelial Ovarian Cancer." European Journal of Clinical Nutrition, vol. 64, no. 1, 2010, pp. 111-4.
    Kotsopoulos J, Hankinson SE, Tworoger SS. Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer. Eur J Clin Nutr. 2010;64(1):111-4.
    Kotsopoulos, J., Hankinson, S. E., & Tworoger, S. S. (2010). Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer. European Journal of Clinical Nutrition, 64(1), pp. 111-4. doi:10.1038/ejcn.2009.109.
    Kotsopoulos J, Hankinson SE, Tworoger SS. Dietary Betaine and Choline Intake Are Not Associated With Risk of Epithelial Ovarian Cancer. Eur J Clin Nutr. 2010;64(1):111-4. PubMed PMID: 19707229.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer. AU - Kotsopoulos,J, AU - Hankinson,S E, AU - Tworoger,S S, Y1 - 2009/08/26/ PY - 2009/8/27/entrez PY - 2009/8/27/pubmed PY - 2010/5/21/medline SP - 111 EP - 4 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 1 N2 - Evidence suggests that nutrients involved in one-carbon metabolism are implicated in ovarian cancer etiology. No studies have evaluated the role of choline, and that of its metabolite, betaine. We prospectively examined the relationship between the intake of these nutrients and ovarian cancer risk among 159 957 participants from the Nurses' Health Study (NHS) and NHSII. The average nutrient intake was assessed every 2-4 years beginning in 1984 (for NHS) and in 1991 (for NHSII). With up to 22 years of follow-up per cohort, 526 incident cases of ovarian cancer were diagnosed. There were no associations between total choline, betaine, as well as choline plus betaine intake and ovarian cancer risk (for example, relative risk, top vs bottom quintile of choline=0.98; 95% confidence interval: 0.73-1.31; P(trend)=0.81). Results did not vary by alcohol consumption, folate intake or after the exclusion of cases diagnosed during the 4-year period after dietary assessment. These data provide little evidence for a role of these nutrients in ovarian cancer etiology. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/19707229/Dietary_betaine_and_choline_intake_are_not_associated_with_risk_of_epithelial_ovarian_cancer_ L2 - http://dx.doi.org/10.1038/ejcn.2009.109 DB - PRIME DP - Unbound Medicine ER -