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Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer.
Eur J Clin Nutr 2010; 64(1):111-4EJ

Abstract

Evidence suggests that nutrients involved in one-carbon metabolism are implicated in ovarian cancer etiology. No studies have evaluated the role of choline, and that of its metabolite, betaine. We prospectively examined the relationship between the intake of these nutrients and ovarian cancer risk among 159 957 participants from the Nurses' Health Study (NHS) and NHSII. The average nutrient intake was assessed every 2-4 years beginning in 1984 (for NHS) and in 1991 (for NHSII). With up to 22 years of follow-up per cohort, 526 incident cases of ovarian cancer were diagnosed. There were no associations between total choline, betaine, as well as choline plus betaine intake and ovarian cancer risk (for example, relative risk, top vs bottom quintile of choline=0.98; 95% confidence interval: 0.73-1.31; P(trend)=0.81). Results did not vary by alcohol consumption, folate intake or after the exclusion of cases diagnosed during the 4-year period after dietary assessment. These data provide little evidence for a role of these nutrients in ovarian cancer etiology.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. nhjok@channing.harvard.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19707229

Citation

Kotsopoulos, J, et al. "Dietary Betaine and Choline Intake Are Not Associated With Risk of Epithelial Ovarian Cancer." European Journal of Clinical Nutrition, vol. 64, no. 1, 2010, pp. 111-4.
Kotsopoulos J, Hankinson SE, Tworoger SS. Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer. Eur J Clin Nutr. 2010;64(1):111-4.
Kotsopoulos, J., Hankinson, S. E., & Tworoger, S. S. (2010). Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer. European Journal of Clinical Nutrition, 64(1), pp. 111-4. doi:10.1038/ejcn.2009.109.
Kotsopoulos J, Hankinson SE, Tworoger SS. Dietary Betaine and Choline Intake Are Not Associated With Risk of Epithelial Ovarian Cancer. Eur J Clin Nutr. 2010;64(1):111-4. PubMed PMID: 19707229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary betaine and choline intake are not associated with risk of epithelial ovarian cancer. AU - Kotsopoulos,J, AU - Hankinson,S E, AU - Tworoger,S S, Y1 - 2009/08/26/ PY - 2009/8/27/entrez PY - 2009/8/27/pubmed PY - 2010/5/21/medline SP - 111 EP - 4 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 1 N2 - Evidence suggests that nutrients involved in one-carbon metabolism are implicated in ovarian cancer etiology. No studies have evaluated the role of choline, and that of its metabolite, betaine. We prospectively examined the relationship between the intake of these nutrients and ovarian cancer risk among 159 957 participants from the Nurses' Health Study (NHS) and NHSII. The average nutrient intake was assessed every 2-4 years beginning in 1984 (for NHS) and in 1991 (for NHSII). With up to 22 years of follow-up per cohort, 526 incident cases of ovarian cancer were diagnosed. There were no associations between total choline, betaine, as well as choline plus betaine intake and ovarian cancer risk (for example, relative risk, top vs bottom quintile of choline=0.98; 95% confidence interval: 0.73-1.31; P(trend)=0.81). Results did not vary by alcohol consumption, folate intake or after the exclusion of cases diagnosed during the 4-year period after dietary assessment. These data provide little evidence for a role of these nutrients in ovarian cancer etiology. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/19707229/Dietary_betaine_and_choline_intake_are_not_associated_with_risk_of_epithelial_ovarian_cancer_ L2 - http://dx.doi.org/10.1038/ejcn.2009.109 DB - PRIME DP - Unbound Medicine ER -