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Decreased bone mineral density in adults born with very low birth weight: a cohort study.
PLoS Med. 2009 Aug; 6(8):e1000135.PM

Abstract

BACKGROUND

Very-low-birth-weight (VLBW, <1,500 g) infants have compromised bone mass accrual during childhood, but it is unclear whether this results in subnormal peak bone mass and increased risk of impaired skeletal health in adulthood. We hypothesized that VLBW is associated with reduced bone mineral density (BMD) in adulthood.

METHODS AND FINDINGS

The Helsinki Study of Very Low Birth Weight Adults is a multidisciplinary cohort study representative of all VLBW births within the larger Helsinki area from 1978 to 1985. This study evaluated skeletal health in 144 such participants (all born preterm, mean gestational age 29.3 wk, birth weight 1,127 g, birth weight Z score 1.3), and in 139 comparison participants born at term, matched for sex, age, and birth hospital. BMD was measured by dual energy X-ray absorptiometry at age 18.5 to 27.1 y. Adults born with VLBW had, in comparison to participants born at term, a 0.51-unit (95% confidence interval [CI] 0.28-0.75) lower lumbar spine Z score and a 0.56-unit (95% CI 0.34-0.78) lower femoral neck Z score for areal BMD. These differences remained statistically significant after adjustment for the VLBW adults' shorter height and lower self-reported exercise intensity.

CONCLUSIONS

Young adults born with VLBW, when studied close to the age of peak bone mass, have significantly lower BMD than do their term-born peers. This suggests that compromised childhood bone mass accrual in preterm VLBW children translates into increased risk for osteoporosis in adulthood, warranting vigilance in osteoporosis prevention.

Authors+Show Affiliations

Hospital for Children and Adolescents, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland. petteri.hovi@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19707270

Citation

Hovi, Petteri, et al. "Decreased Bone Mineral Density in Adults Born With Very Low Birth Weight: a Cohort Study." PLoS Medicine, vol. 6, no. 8, 2009, pp. e1000135.
Hovi P, Andersson S, Järvenpää AL, et al. Decreased bone mineral density in adults born with very low birth weight: a cohort study. PLoS Med. 2009;6(8):e1000135.
Hovi, P., Andersson, S., Järvenpää, A. L., Eriksson, J. G., Strang-Karlsson, S., Kajantie, E., & Mäkitie, O. (2009). Decreased bone mineral density in adults born with very low birth weight: a cohort study. PLoS Medicine, 6(8), e1000135. https://doi.org/10.1371/journal.pmed.1000135
Hovi P, et al. Decreased Bone Mineral Density in Adults Born With Very Low Birth Weight: a Cohort Study. PLoS Med. 2009;6(8):e1000135. PubMed PMID: 19707270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased bone mineral density in adults born with very low birth weight: a cohort study. AU - Hovi,Petteri, AU - Andersson,Sture, AU - Järvenpää,Anna-Liisa, AU - Eriksson,Johan G, AU - Strang-Karlsson,Sonja, AU - Kajantie,Eero, AU - Mäkitie,Outi, Y1 - 2009/08/25/ PY - 2009/01/09/received PY - 2009/07/17/accepted PY - 2009/8/27/entrez PY - 2009/8/27/pubmed PY - 2009/10/30/medline SP - e1000135 EP - e1000135 JF - PLoS medicine JO - PLoS Med VL - 6 IS - 8 N2 - BACKGROUND: Very-low-birth-weight (VLBW, <1,500 g) infants have compromised bone mass accrual during childhood, but it is unclear whether this results in subnormal peak bone mass and increased risk of impaired skeletal health in adulthood. We hypothesized that VLBW is associated with reduced bone mineral density (BMD) in adulthood. METHODS AND FINDINGS: The Helsinki Study of Very Low Birth Weight Adults is a multidisciplinary cohort study representative of all VLBW births within the larger Helsinki area from 1978 to 1985. This study evaluated skeletal health in 144 such participants (all born preterm, mean gestational age 29.3 wk, birth weight 1,127 g, birth weight Z score 1.3), and in 139 comparison participants born at term, matched for sex, age, and birth hospital. BMD was measured by dual energy X-ray absorptiometry at age 18.5 to 27.1 y. Adults born with VLBW had, in comparison to participants born at term, a 0.51-unit (95% confidence interval [CI] 0.28-0.75) lower lumbar spine Z score and a 0.56-unit (95% CI 0.34-0.78) lower femoral neck Z score for areal BMD. These differences remained statistically significant after adjustment for the VLBW adults' shorter height and lower self-reported exercise intensity. CONCLUSIONS: Young adults born with VLBW, when studied close to the age of peak bone mass, have significantly lower BMD than do their term-born peers. This suggests that compromised childhood bone mass accrual in preterm VLBW children translates into increased risk for osteoporosis in adulthood, warranting vigilance in osteoporosis prevention. SN - 1549-1676 UR - https://www.unboundmedicine.com/medline/citation/19707270/Decreased_bone_mineral_density_in_adults_born_with_very_low_birth_weight:_a_cohort_study_ L2 - https://dx.plos.org/10.1371/journal.pmed.1000135 DB - PRIME DP - Unbound Medicine ER -