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Infectious disease hospitalizations in the United States.
Clin Infect Dis. 2009 Oct 01; 49(7):1025-35.CI

Abstract

BACKGROUND

Infectious diseases (IDs) cause widespread morbidity and mortality. We describe the epidemiology of ID hospitalizations in the United States with use of a nationally representative database.

METHODS

First-listed ID hospitalizations in the United States were analyzed using the Nationwide Inpatient Sample for 1998-2006. Hospitalization rates were calculated overall for IDs and for specific ID groups.

RESULTS

An estimated 40,085,978 (standard error, 255,418) hospitalizations with a first-listed ID occurred during 1998-2006, for an age-adjusted hospitalization rate of 154.4 (95% confidence interval, 153.3-155.5) hospitalizations per 10,000 persons. The rate increased slightly over the study period (152.5 [95% confidence interval, 149.6-155.4] in 1998 vs 162.2 [95% confidence interval, 158.7-165.5] in 2006); an increase was seen for both sexes, for older patients, and for Hispanic patients. Among those aged 5-39 years, female patients had a significantly higher hospitalization rate than did male patients; male patients had higher rates among the youngest children and adults aged > or = 40 years. Approximately 4.5 million hospital days and $865 billion in hospital charges were associated with primary ID hospitalizations over the study period. Lower respiratory tract infections were the most commonly listed ID (34.4%), followed by kidney, urinary tract, and bladder infections; cellulitis; and abdominal and rectal infections.

CONCLUSIONS

The ID hospitalization rate increased during 1998-2006, reflecting an increase in ID hospitalizations among adults aged > or = 30 years, particularly older adults. Differences in trends and patterns of ID hospitalizations were noted by sex, age group, and race. Lower respiratory tract infections accounted for the largest proportion of ID hospitalizations. Future efforts should focus on preventive measures and improving early interventions for IDs.

Authors+Show Affiliations

Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Rockville, Maryland, USA. KYorita@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19708796

Citation

Christensen, Krista L Yorita, et al. "Infectious Disease Hospitalizations in the United States." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 49, no. 7, 2009, pp. 1025-35.
Christensen KL, Holman RC, Steiner CA, et al. Infectious disease hospitalizations in the United States. Clin Infect Dis. 2009;49(7):1025-35.
Christensen, K. L., Holman, R. C., Steiner, C. A., Sejvar, J. J., Stoll, B. J., & Schonberger, L. B. (2009). Infectious disease hospitalizations in the United States. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 49(7), 1025-35. https://doi.org/10.1086/605562
Christensen KL, et al. Infectious Disease Hospitalizations in the United States. Clin Infect Dis. 2009 Oct 1;49(7):1025-35. PubMed PMID: 19708796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infectious disease hospitalizations in the United States. AU - Christensen,Krista L Yorita, AU - Holman,Robert C, AU - Steiner,Claudia A, AU - Sejvar,James J, AU - Stoll,Barbara J, AU - Schonberger,Lawrence B, PY - 2009/8/28/entrez PY - 2009/8/28/pubmed PY - 2009/11/3/medline SP - 1025 EP - 35 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 49 IS - 7 N2 - BACKGROUND: Infectious diseases (IDs) cause widespread morbidity and mortality. We describe the epidemiology of ID hospitalizations in the United States with use of a nationally representative database. METHODS: First-listed ID hospitalizations in the United States were analyzed using the Nationwide Inpatient Sample for 1998-2006. Hospitalization rates were calculated overall for IDs and for specific ID groups. RESULTS: An estimated 40,085,978 (standard error, 255,418) hospitalizations with a first-listed ID occurred during 1998-2006, for an age-adjusted hospitalization rate of 154.4 (95% confidence interval, 153.3-155.5) hospitalizations per 10,000 persons. The rate increased slightly over the study period (152.5 [95% confidence interval, 149.6-155.4] in 1998 vs 162.2 [95% confidence interval, 158.7-165.5] in 2006); an increase was seen for both sexes, for older patients, and for Hispanic patients. Among those aged 5-39 years, female patients had a significantly higher hospitalization rate than did male patients; male patients had higher rates among the youngest children and adults aged > or = 40 years. Approximately 4.5 million hospital days and $865 billion in hospital charges were associated with primary ID hospitalizations over the study period. Lower respiratory tract infections were the most commonly listed ID (34.4%), followed by kidney, urinary tract, and bladder infections; cellulitis; and abdominal and rectal infections. CONCLUSIONS: The ID hospitalization rate increased during 1998-2006, reflecting an increase in ID hospitalizations among adults aged > or = 30 years, particularly older adults. Differences in trends and patterns of ID hospitalizations were noted by sex, age group, and race. Lower respiratory tract infections accounted for the largest proportion of ID hospitalizations. Future efforts should focus on preventive measures and improving early interventions for IDs. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/19708796/Infectious_disease_hospitalizations_in_the_United_States_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/605562 DB - PRIME DP - Unbound Medicine ER -