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Effects of gabapentin on sleep in menopausal women with hot flashes as measured by a Pittsburgh Sleep Quality Index factor scoring model.
J Womens Health (Larchmt). 2009 Sep; 18(9):1355-60.JW

Abstract

OBJECTIVE

The aim of this research was to analyze gabapentin's effect on Pittsburgh Sleep Quality Index (PSQI) scores in menopausal women.

METHODS

Secondary analysis of data from a cohort of menopausal women participating in a randomized, double-blind, placebo-controlled trial of gabapentin 300 mg three times daily (TID) for hot flashes. The outcomes of interest were PSQI global and factor scores at weeks 4 and 12.

RESULTS

Subjects randomized to gabapentin demonstrated improvement in the sleep quality factor score, compared to placebo-treated subjects, at 4 and 12 weeks (p < 0.03). There was also gabapentin-associated improvement in the global PSQI score (p = 0.004) and the sleep efficiency factor score (p = 0.05) at 4 weeks. There was no significant effect of gabapentin on the daily disturbance factor score.

CONCLUSIONS

Gabapentin may improve sleep quality in menopausal women with hot flashes. These results warrant further prospective investigation, with an emphasis on measuring subjective sleep quality and maintenance.

Authors+Show Affiliations

Department of Neurology, University of Rochester School of Medicine and Dentistry, Strong Sleep Disorders Center, Rochester, New York 14618, USA. Michael_Yurcheshen@urmc.rochester.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19708803

Citation

Yurcheshen, Michael E., et al. "Effects of Gabapentin On Sleep in Menopausal Women With Hot Flashes as Measured By a Pittsburgh Sleep Quality Index Factor Scoring Model." Journal of Women's Health (2002), vol. 18, no. 9, 2009, pp. 1355-60.
Yurcheshen ME, Guttuso T, McDermott M, et al. Effects of gabapentin on sleep in menopausal women with hot flashes as measured by a Pittsburgh Sleep Quality Index factor scoring model. J Womens Health (Larchmt). 2009;18(9):1355-60.
Yurcheshen, M. E., Guttuso, T., McDermott, M., Holloway, R. G., & Perlis, M. (2009). Effects of gabapentin on sleep in menopausal women with hot flashes as measured by a Pittsburgh Sleep Quality Index factor scoring model. Journal of Women's Health (2002), 18(9), 1355-60. https://doi.org/10.1089/jwh.2008.1257
Yurcheshen ME, et al. Effects of Gabapentin On Sleep in Menopausal Women With Hot Flashes as Measured By a Pittsburgh Sleep Quality Index Factor Scoring Model. J Womens Health (Larchmt). 2009;18(9):1355-60. PubMed PMID: 19708803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of gabapentin on sleep in menopausal women with hot flashes as measured by a Pittsburgh Sleep Quality Index factor scoring model. AU - Yurcheshen,Michael E, AU - Guttuso,Thomas,Jr AU - McDermott,Michael, AU - Holloway,Robert G, AU - Perlis,Michael, PY - 2009/8/28/entrez PY - 2009/8/28/pubmed PY - 2009/11/11/medline SP - 1355 EP - 60 JF - Journal of women's health (2002) JO - J Womens Health (Larchmt) VL - 18 IS - 9 N2 - OBJECTIVE: The aim of this research was to analyze gabapentin's effect on Pittsburgh Sleep Quality Index (PSQI) scores in menopausal women. METHODS: Secondary analysis of data from a cohort of menopausal women participating in a randomized, double-blind, placebo-controlled trial of gabapentin 300 mg three times daily (TID) for hot flashes. The outcomes of interest were PSQI global and factor scores at weeks 4 and 12. RESULTS: Subjects randomized to gabapentin demonstrated improvement in the sleep quality factor score, compared to placebo-treated subjects, at 4 and 12 weeks (p < 0.03). There was also gabapentin-associated improvement in the global PSQI score (p = 0.004) and the sleep efficiency factor score (p = 0.05) at 4 weeks. There was no significant effect of gabapentin on the daily disturbance factor score. CONCLUSIONS: Gabapentin may improve sleep quality in menopausal women with hot flashes. These results warrant further prospective investigation, with an emphasis on measuring subjective sleep quality and maintenance. SN - 1931-843X UR - https://www.unboundmedicine.com/medline/citation/19708803/Effects_of_gabapentin_on_sleep_in_menopausal_women_with_hot_flashes_as_measured_by_a_Pittsburgh_Sleep_Quality_Index_factor_scoring_model_ L2 - https://www.liebertpub.com/doi/10.1089/jwh.2008.1257?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -