Tags

Type your tag names separated by a space and hit enter

Severe necrotizing stomatitis and osteomyelitis after chemotherapy for acute leukaemia.
Aust Dent J. 2009 Sep; 54(3):262-5.AD

Abstract

BACKGROUND

Leukaemia is a malignant neoplasm characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic patients can be attributed to the direct and indirect effects of immunosuppressive chemotherapy.

METHODS

This case report describes severe maxillary and mandibular necrotizing stomatitis and osteomyelitis in a young female patient after chemotherapy for acute leukaemia. On physical examination, the patient presented malnourished with pale skin, cervical lymphadenitis, frequent fever and generalized pain. The intra-oral clinical examination found halitosis, multiple ulcers, necrotizing stomatitis and osteomyelitis located in the maxillary and mandibular regions. The necrotizing stomatitis and osteomyelitis were treated locally with atraumatic removal of the necrotized tissues. The patient received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of chlorhexidine. She was also treated with systemic metronidazole and amoxicillin for 21 days.

RESULTS

During the course of management the patient's oral condition improved with some re-epithelialization being noted. However, severe alveolar bone destruction remained evident. Thirty-two months after presentation of the initial symptoms, the patient died due to complications related to leukaemia recurrence (haemorrhage, sepsis and respiratory distress syndrome).

CONCLUSIONS

Dental monitoring during cancer treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment.

Authors+Show Affiliations

Department of Dentistry, Ponta Grossa State University, Ponta Grossa, Paraná, Brazil. fasantos11@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19709116

Citation

Santos, F A., et al. "Severe Necrotizing Stomatitis and Osteomyelitis After Chemotherapy for Acute Leukaemia." Australian Dental Journal, vol. 54, no. 3, 2009, pp. 262-5.
Santos FA, Pochapski MT, Pilatti GL, et al. Severe necrotizing stomatitis and osteomyelitis after chemotherapy for acute leukaemia. Aust Dent J. 2009;54(3):262-5.
Santos, F. A., Pochapski, M. T., Pilatti, G. L., Kozlowski, V. A., Goiris, F. A., & Groppo, F. C. (2009). Severe necrotizing stomatitis and osteomyelitis after chemotherapy for acute leukaemia. Australian Dental Journal, 54(3), 262-5. https://doi.org/10.1111/j.1834-7819.2009.01129.x
Santos FA, et al. Severe Necrotizing Stomatitis and Osteomyelitis After Chemotherapy for Acute Leukaemia. Aust Dent J. 2009;54(3):262-5. PubMed PMID: 19709116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe necrotizing stomatitis and osteomyelitis after chemotherapy for acute leukaemia. AU - Santos,F A, AU - Pochapski,M T, AU - Pilatti,G L, AU - Kozlowski,V A,Jr AU - Goiris,F A J, AU - Groppo,F C, PY - 2009/8/28/entrez PY - 2009/8/28/pubmed PY - 2009/12/16/medline SP - 262 EP - 5 JF - Australian dental journal JO - Aust Dent J VL - 54 IS - 3 N2 - BACKGROUND: Leukaemia is a malignant neoplasm characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic patients can be attributed to the direct and indirect effects of immunosuppressive chemotherapy. METHODS: This case report describes severe maxillary and mandibular necrotizing stomatitis and osteomyelitis in a young female patient after chemotherapy for acute leukaemia. On physical examination, the patient presented malnourished with pale skin, cervical lymphadenitis, frequent fever and generalized pain. The intra-oral clinical examination found halitosis, multiple ulcers, necrotizing stomatitis and osteomyelitis located in the maxillary and mandibular regions. The necrotizing stomatitis and osteomyelitis were treated locally with atraumatic removal of the necrotized tissues. The patient received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of chlorhexidine. She was also treated with systemic metronidazole and amoxicillin for 21 days. RESULTS: During the course of management the patient's oral condition improved with some re-epithelialization being noted. However, severe alveolar bone destruction remained evident. Thirty-two months after presentation of the initial symptoms, the patient died due to complications related to leukaemia recurrence (haemorrhage, sepsis and respiratory distress syndrome). CONCLUSIONS: Dental monitoring during cancer treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment. SN - 1834-7819 UR - https://www.unboundmedicine.com/medline/citation/19709116/Severe_necrotizing_stomatitis_and_osteomyelitis_after_chemotherapy_for_acute_leukaemia_ L2 - https://doi.org/10.1111/j.1834-7819.2009.01129.x DB - PRIME DP - Unbound Medicine ER -