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The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins.
Clin Nutr. 2010 Feb; 29(1):112-8.CN

Abstract

BACKGROUND & AIMS

Intake of 2-3 g/d of plant stanols as esters lowers LDL cholesterol level, but there is no information about the efficacy and safety of a respective very high daily intake. We studied the effects of 8.8 g/d of plant stanols as esters on serum lipids and safety variables in subjects with mild to moderate hypercholesterolemia.

METHODS

In a randomized, double-blind, placebo-controlled study the intervention (n=25) and control (n=24) groups consumed spread and drink enriched or not with plant stanol esters for 10 weeks.

RESULTS

Plant stanols reduced serum total and LDL cholesterol concentrations by 12.8 and 17.3% from baseline and by 12.0 and 17.1% from controls (P<0.01 for all). Liver enzymes, markers of hemolysis, and blood cells were unchanged. Serum vitamins A, D, and gamma-tocopherol concentrations, and the ratios of alpha-tocopherol to cholesterol were unchanged. Serum beta-carotene concentrations decreased significantly from baseline and were different from controls even when adjusted for cholesterol. Serum alpha-carotene concentration and alpha-carotene/cholesterol ratio were not different from controls.

CONCLUSIONS

High intake of plant stanols reduced LDL cholesterol values without any other side effects than reduction of serum beta-carotene concentration. However, the end product, serum vitamin A levels, were unchanged. The results suggest that plant stanol ester intake can be increased to induce a greater cholesterol lowering effect.

Authors+Show Affiliations

Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland. helena.gylling@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19709787

Citation

Gylling, Helena, et al. "The Effect of a Very High Daily Plant Stanol Ester Intake On Serum Lipids, Carotenoids, and Fat-soluble Vitamins." Clinical Nutrition (Edinburgh, Scotland), vol. 29, no. 1, 2010, pp. 112-8.
Gylling H, Hallikainen M, Nissinen MJ, et al. The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins. Clin Nutr. 2010;29(1):112-8.
Gylling, H., Hallikainen, M., Nissinen, M. J., & Miettinen, T. A. (2010). The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins. Clinical Nutrition (Edinburgh, Scotland), 29(1), 112-8. https://doi.org/10.1016/j.clnu.2009.08.005
Gylling H, et al. The Effect of a Very High Daily Plant Stanol Ester Intake On Serum Lipids, Carotenoids, and Fat-soluble Vitamins. Clin Nutr. 2010;29(1):112-8. PubMed PMID: 19709787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of a very high daily plant stanol ester intake on serum lipids, carotenoids, and fat-soluble vitamins. AU - Gylling,Helena, AU - Hallikainen,Maarit, AU - Nissinen,Markku J, AU - Miettinen,Tatu A, Y1 - 2009/08/26/ PY - 2009/02/24/received PY - 2009/07/24/revised PY - 2009/08/05/accepted PY - 2009/8/28/entrez PY - 2009/8/28/pubmed PY - 2010/5/13/medline SP - 112 EP - 8 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 29 IS - 1 N2 - BACKGROUND & AIMS: Intake of 2-3 g/d of plant stanols as esters lowers LDL cholesterol level, but there is no information about the efficacy and safety of a respective very high daily intake. We studied the effects of 8.8 g/d of plant stanols as esters on serum lipids and safety variables in subjects with mild to moderate hypercholesterolemia. METHODS: In a randomized, double-blind, placebo-controlled study the intervention (n=25) and control (n=24) groups consumed spread and drink enriched or not with plant stanol esters for 10 weeks. RESULTS: Plant stanols reduced serum total and LDL cholesterol concentrations by 12.8 and 17.3% from baseline and by 12.0 and 17.1% from controls (P<0.01 for all). Liver enzymes, markers of hemolysis, and blood cells were unchanged. Serum vitamins A, D, and gamma-tocopherol concentrations, and the ratios of alpha-tocopherol to cholesterol were unchanged. Serum beta-carotene concentrations decreased significantly from baseline and were different from controls even when adjusted for cholesterol. Serum alpha-carotene concentration and alpha-carotene/cholesterol ratio were not different from controls. CONCLUSIONS: High intake of plant stanols reduced LDL cholesterol values without any other side effects than reduction of serum beta-carotene concentration. However, the end product, serum vitamin A levels, were unchanged. The results suggest that plant stanol ester intake can be increased to induce a greater cholesterol lowering effect. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/19709787/The_effect_of_a_very_high_daily_plant_stanol_ester_intake_on_serum_lipids_carotenoids_and_fat_soluble_vitamins_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(09)00169-1 DB - PRIME DP - Unbound Medicine ER -