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Anxiety and depressive disorders in offspring at high risk for anxiety: a meta-analysis.
J Anxiety Disord. 2009 Dec; 23(8):1158-64.JA

Abstract

This paper presents a meta-analysis of studies examining prevalence of psychopathology among offspring of anxiety-disordered parents, with the purpose of determining overall risk among these offspring for developing anxiety and depressive disorders. Pooled odds ratios for these disorders among high-risk offspring, compared to offspring of psychiatric and non-psychiatric controls, were calculated. Sixteen papers (including three follow-up studies) were identified, encompassing 1892 offspring (ages 4-25 years). Results revealed that: (1) offspring of parents with anxiety disorders have greater risk for anxiety and depressive disorders than offspring of non-psychiatric controls (ORs=3.91 and 2.67, respectively) and greater risk for anxiety disorders than offspring of psychiatric controls (OR=1.84); (2) offspring of anxious parents have significantly greater odds of having each type of anxiety disorder and MDD compared to offspring of non-psychiatric controls (ORs range from 1.96 to 8.69); and (3) offspring of parents with anxiety only, anxiety plus MDD, and MDD only have similar odds of having anxiety and depressive disorders but significantly higher odds than offspring of parents without disorder. Results suggest that parental anxiety disorders confer significant risk for anxiety and depression in offspring. Additional studies are needed to examine whether there are differences among specific parental anxiety disorders.

Authors+Show Affiliations

Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital/Harvard Medical School, Suite 2000, Cambridge, MA 02138, USA. jmicco@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

19709850

Citation

Micco, Jamie A., et al. "Anxiety and Depressive Disorders in Offspring at High Risk for Anxiety: a Meta-analysis." Journal of Anxiety Disorders, vol. 23, no. 8, 2009, pp. 1158-64.
Micco JA, Henin A, Mick E, et al. Anxiety and depressive disorders in offspring at high risk for anxiety: a meta-analysis. J Anxiety Disord. 2009;23(8):1158-64.
Micco, J. A., Henin, A., Mick, E., Kim, S., Hopkins, C. A., Biederman, J., & Hirshfeld-Becker, D. R. (2009). Anxiety and depressive disorders in offspring at high risk for anxiety: a meta-analysis. Journal of Anxiety Disorders, 23(8), 1158-64. https://doi.org/10.1016/j.janxdis.2009.07.021
Micco JA, et al. Anxiety and Depressive Disorders in Offspring at High Risk for Anxiety: a Meta-analysis. J Anxiety Disord. 2009;23(8):1158-64. PubMed PMID: 19709850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiety and depressive disorders in offspring at high risk for anxiety: a meta-analysis. AU - Micco,Jamie A, AU - Henin,Aude, AU - Mick,Eric, AU - Kim,Susie, AU - Hopkins,Courtney A, AU - Biederman,Joseph, AU - Hirshfeld-Becker,Dina R, Y1 - 2009/08/06/ PY - 2009/03/07/received PY - 2009/07/23/revised PY - 2009/07/23/accepted PY - 2009/8/28/entrez PY - 2009/8/28/pubmed PY - 2009/12/31/medline SP - 1158 EP - 64 JF - Journal of anxiety disorders JO - J Anxiety Disord VL - 23 IS - 8 N2 - This paper presents a meta-analysis of studies examining prevalence of psychopathology among offspring of anxiety-disordered parents, with the purpose of determining overall risk among these offspring for developing anxiety and depressive disorders. Pooled odds ratios for these disorders among high-risk offspring, compared to offspring of psychiatric and non-psychiatric controls, were calculated. Sixteen papers (including three follow-up studies) were identified, encompassing 1892 offspring (ages 4-25 years). Results revealed that: (1) offspring of parents with anxiety disorders have greater risk for anxiety and depressive disorders than offspring of non-psychiatric controls (ORs=3.91 and 2.67, respectively) and greater risk for anxiety disorders than offspring of psychiatric controls (OR=1.84); (2) offspring of anxious parents have significantly greater odds of having each type of anxiety disorder and MDD compared to offspring of non-psychiatric controls (ORs range from 1.96 to 8.69); and (3) offspring of parents with anxiety only, anxiety plus MDD, and MDD only have similar odds of having anxiety and depressive disorders but significantly higher odds than offspring of parents without disorder. Results suggest that parental anxiety disorders confer significant risk for anxiety and depression in offspring. Additional studies are needed to examine whether there are differences among specific parental anxiety disorders. SN - 1873-7897 UR - https://www.unboundmedicine.com/medline/citation/19709850/Anxiety_and_depressive_disorders_in_offspring_at_high_risk_for_anxiety:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-6185(09)00152-2 DB - PRIME DP - Unbound Medicine ER -