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Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: an intraobserver, interobserver, and interscan variability study.
J Cardiovasc Comput Tomogr. 2009 Sep-Oct; 3(5):312-20.JC

Abstract

BACKGROUND

Interscan variability of coronary arterial plaque volume and composition quantification with coronary computed tomographic angiography (CCTA), an important attribute when considering CCTA as a serial modality, has not been examined.

OBJECTIVE

We sought to systematically determine intraobserver- and interobserver-interscan reproducibility of these measures.

METHODS

Two blinded, experienced readers independently evaluated proximal coronary segments on CCTAs from 30 patients who underwent 2 scans within 200 days (median, 124 days; interquartile range, 49-155 days) without experiencing an interim acute coronary event. Readers recorded number of plaques and, in plaques that met a preset minimal length criterion, quantified total, calcified plaque (CP), and noncalcified plaque (NCP) volumes and percentage of total plaque volume occupied by NCP.

RESULTS

Of 89 total segments studied, 36 contained detectable plaque, and 26 met criterion for quantification. Intraobserver, interobserver, and interscan agreements for normal segments were 100%. Intraobserver-interscan correlations of total, CP, and NCP volumes and percentage of NCP were excellent (r=0.93-0.97, P values<0.001). Interobserver-interscan correlations for all measures were also very good (r=0.81-0.96, P values<0.001). Variability in plaque volume quantification was significant, exceeding 60% of the averaged paired plaque volumes in the best-case scenario (interobserver-interscan CP volume). Quantification of percentage of NCP composition by volume was more consistent, with <24% variation in the worst-case scenario (interobserver-interscan).

CONCLUSION

CCTA shows promise for quantifying serial coronary plaque change. Currently, the most robust measure seems to be percentage of plaque composition, rather than plaque volume. For smaller plaques, volume quantification remains challenging.

Authors+Show Affiliations

Department of Medicine, 8700 Beverly Boulevard, Taper Building Room 1258, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. victor.cheng@cshs.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19709947

Citation

Cheng, Victor Y., et al. "Reproducibility of Coronary Artery Plaque Volume and Composition Quantification By 64-detector Row Coronary Computed Tomographic Angiography: an Intraobserver, Interobserver, and Interscan Variability Study." Journal of Cardiovascular Computed Tomography, vol. 3, no. 5, 2009, pp. 312-20.
Cheng VY, Nakazato R, Dey D, et al. Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: an intraobserver, interobserver, and interscan variability study. J Cardiovasc Comput Tomogr. 2009;3(5):312-20.
Cheng, V. Y., Nakazato, R., Dey, D., Gurudevan, S., Tabak, J., Budoff, M. J., Karlsberg, R. P., Min, J., & Berman, D. S. (2009). Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: an intraobserver, interobserver, and interscan variability study. Journal of Cardiovascular Computed Tomography, 3(5), 312-20. https://doi.org/10.1016/j.jcct.2009.07.001
Cheng VY, et al. Reproducibility of Coronary Artery Plaque Volume and Composition Quantification By 64-detector Row Coronary Computed Tomographic Angiography: an Intraobserver, Interobserver, and Interscan Variability Study. J Cardiovasc Comput Tomogr. 2009 Sep-Oct;3(5):312-20. PubMed PMID: 19709947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproducibility of coronary artery plaque volume and composition quantification by 64-detector row coronary computed tomographic angiography: an intraobserver, interobserver, and interscan variability study. AU - Cheng,Victor Y, AU - Nakazato,Ryo, AU - Dey,Damini, AU - Gurudevan,Swaminatha, AU - Tabak,Joshua, AU - Budoff,Matthew J, AU - Karlsberg,Ronald P, AU - Min,James, AU - Berman,Daniel S, Y1 - 2009/07/30/ PY - 2009/04/02/received PY - 2009/05/28/revised PY - 2009/07/20/accepted PY - 2009/8/28/entrez PY - 2009/8/28/pubmed PY - 2010/1/8/medline SP - 312 EP - 20 JF - Journal of cardiovascular computed tomography JO - J Cardiovasc Comput Tomogr VL - 3 IS - 5 N2 - BACKGROUND: Interscan variability of coronary arterial plaque volume and composition quantification with coronary computed tomographic angiography (CCTA), an important attribute when considering CCTA as a serial modality, has not been examined. OBJECTIVE: We sought to systematically determine intraobserver- and interobserver-interscan reproducibility of these measures. METHODS: Two blinded, experienced readers independently evaluated proximal coronary segments on CCTAs from 30 patients who underwent 2 scans within 200 days (median, 124 days; interquartile range, 49-155 days) without experiencing an interim acute coronary event. Readers recorded number of plaques and, in plaques that met a preset minimal length criterion, quantified total, calcified plaque (CP), and noncalcified plaque (NCP) volumes and percentage of total plaque volume occupied by NCP. RESULTS: Of 89 total segments studied, 36 contained detectable plaque, and 26 met criterion for quantification. Intraobserver, interobserver, and interscan agreements for normal segments were 100%. Intraobserver-interscan correlations of total, CP, and NCP volumes and percentage of NCP were excellent (r=0.93-0.97, P values<0.001). Interobserver-interscan correlations for all measures were also very good (r=0.81-0.96, P values<0.001). Variability in plaque volume quantification was significant, exceeding 60% of the averaged paired plaque volumes in the best-case scenario (interobserver-interscan CP volume). Quantification of percentage of NCP composition by volume was more consistent, with <24% variation in the worst-case scenario (interobserver-interscan). CONCLUSION: CCTA shows promise for quantifying serial coronary plaque change. Currently, the most robust measure seems to be percentage of plaque composition, rather than plaque volume. For smaller plaques, volume quantification remains challenging. SN - 1876-861X UR - https://www.unboundmedicine.com/medline/citation/19709947/Reproducibility_of_coronary_artery_plaque_volume_and_composition_quantification_by_64_detector_row_coronary_computed_tomographic_angiography:_an_intraobserver_interobserver_and_interscan_variability_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1934-5925(09)00403-1 DB - PRIME DP - Unbound Medicine ER -