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Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark.
Cancer Causes Control. 2009 Nov; 20(9):1715-21.CC

Abstract

OBJECTIVE

The aim of this study was to investigate the association between the content of marine n-3 polyunsaturated fatty acids (PUFA) in adipose tissue, a biomarker for the long-term intake of seafood, and the subsequent development of breast cancer (BC).

DESIGN

We designed a case-cohort study based on a cohort of healthy Danish women, who in the 1990 s donated adipose tissue biopsies to a biobank in order to investigate the role of diet for the development of cancer and chronic disease. During follow-up, incident cases of BC were identified through national registries, and the content of n-3 PUFA in adipose tissue was compared between cases and the cohort sample.

RESULTS

During follow-up, 463 new cases of BC were identified. After adjusting for potential confounders, no significant association between the content of marine n-3 PUFA and BC was found. When comparing the highest with the lowest quintile, the hazard ratio (HR) was 0.96 (95% CI 0.64-1.43) for total marine n-3 PUFA, 0.84 (95% CI 0.58-1.23) for eicosapentaenoic acid (EPA), and 1.08 (95% CI 0.73-1.58) for docosahexaenoic acid (DHA).

CONCLUSION

This study does not indicate any association between the content of total or individual marine n-3 PUFA in adipose tissue and development of BC.

Authors+Show Affiliations

Department of Oncology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, 9100, Aalborg, Denmark. p.witt@rn.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19711189

Citation

Witt, Petra M., et al. "Marine N-3 Polyunsaturated Fatty Acids in Adipose Tissue and Breast Cancer Risk: a Case-cohort Study From Denmark." Cancer Causes & Control : CCC, vol. 20, no. 9, 2009, pp. 1715-21.
Witt PM, Christensen JH, Schmidt EB, et al. Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark. Cancer Causes Control. 2009;20(9):1715-21.
Witt, P. M., Christensen, J. H., Schmidt, E. B., Dethlefsen, C., Tjønneland, A., Overvad, K., & Ewertz, M. (2009). Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark. Cancer Causes & Control : CCC, 20(9), 1715-21. https://doi.org/10.1007/s10552-009-9423-y
Witt PM, et al. Marine N-3 Polyunsaturated Fatty Acids in Adipose Tissue and Breast Cancer Risk: a Case-cohort Study From Denmark. Cancer Causes Control. 2009;20(9):1715-21. PubMed PMID: 19711189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark. AU - Witt,Petra M, AU - Christensen,Jeppe H, AU - Schmidt,Erik B, AU - Dethlefsen,Claus, AU - Tjønneland,Anne, AU - Overvad,Kim, AU - Ewertz,Marianne, Y1 - 2009/08/27/ PY - 2009/03/30/received PY - 2009/08/11/accepted PY - 2009/8/28/entrez PY - 2009/8/28/pubmed PY - 2010/1/9/medline SP - 1715 EP - 21 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 20 IS - 9 N2 - OBJECTIVE: The aim of this study was to investigate the association between the content of marine n-3 polyunsaturated fatty acids (PUFA) in adipose tissue, a biomarker for the long-term intake of seafood, and the subsequent development of breast cancer (BC). DESIGN: We designed a case-cohort study based on a cohort of healthy Danish women, who in the 1990 s donated adipose tissue biopsies to a biobank in order to investigate the role of diet for the development of cancer and chronic disease. During follow-up, incident cases of BC were identified through national registries, and the content of n-3 PUFA in adipose tissue was compared between cases and the cohort sample. RESULTS: During follow-up, 463 new cases of BC were identified. After adjusting for potential confounders, no significant association between the content of marine n-3 PUFA and BC was found. When comparing the highest with the lowest quintile, the hazard ratio (HR) was 0.96 (95% CI 0.64-1.43) for total marine n-3 PUFA, 0.84 (95% CI 0.58-1.23) for eicosapentaenoic acid (EPA), and 1.08 (95% CI 0.73-1.58) for docosahexaenoic acid (DHA). CONCLUSION: This study does not indicate any association between the content of total or individual marine n-3 PUFA in adipose tissue and development of BC. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/19711189/Marine_n_3_polyunsaturated_fatty_acids_in_adipose_tissue_and_breast_cancer_risk:_a_case_cohort_study_from_Denmark_ L2 - https://doi.org/10.1007/s10552-009-9423-y DB - PRIME DP - Unbound Medicine ER -