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Effect of haloperidol withdrawal on somatostatin level and binding in rat brain.
Biosci Rep. 1990 Feb; 10(1):15-22.BR

Abstract

The effects of withdrawal on the level and specific binding of somatostatin in the frontoparietal cortex and hippocampus of the rat after chronic haloperidol treatment were examined using 125I-Tyr11 somatostatin as tracer. One week after haloperiodol withdrawal the number of specific somatostatin receptors in both brain areas returned to control values, after having decreased as the result of chronic administration. Neither administration of haloperidol nor withdrawal of it affected the levels of somatostatin-like immunoreactivity (SLI) in the two brain areas studied. The return of the somatostatin receptor number to control values after haloperidol withdrawal may be related to the motor side-effects that are clinically observed when the haloperidol treatment is terminated.

Authors+Show Affiliations

Perez-Oso E
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcala de Henares, Madrid, Spain.
Lopez-Ruiz MP
No affiliation info available
Arilla E
No affiliation info available

MeSH

AnimalsBinding, CompetitiveBrainHaloperidolMaleRadioimmunoassayRatsRats, Inbred StrainsReceptors, NeurotransmitterReceptors, SomatostatinSomatostatinSubstance Withdrawal Syndrome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1971188

Citation

Perez-Oso, E, et al. "Effect of Haloperidol Withdrawal On Somatostatin Level and Binding in Rat Brain." Bioscience Reports, vol. 10, no. 1, 1990, pp. 15-22.
Perez-Oso E, Lopez-Ruiz MP, Arilla E. Effect of haloperidol withdrawal on somatostatin level and binding in rat brain. Biosci Rep. 1990;10(1):15-22.
Perez-Oso, E., Lopez-Ruiz, M. P., & Arilla, E. (1990). Effect of haloperidol withdrawal on somatostatin level and binding in rat brain. Bioscience Reports, 10(1), 15-22.
Perez-Oso E, Lopez-Ruiz MP, Arilla E. Effect of Haloperidol Withdrawal On Somatostatin Level and Binding in Rat Brain. Biosci Rep. 1990;10(1):15-22. PubMed PMID: 1971188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of haloperidol withdrawal on somatostatin level and binding in rat brain. AU - Perez-Oso,E, AU - Lopez-Ruiz,M P, AU - Arilla,E, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - 15 EP - 22 JF - Bioscience reports JO - Biosci Rep VL - 10 IS - 1 N2 - The effects of withdrawal on the level and specific binding of somatostatin in the frontoparietal cortex and hippocampus of the rat after chronic haloperidol treatment were examined using 125I-Tyr11 somatostatin as tracer. One week after haloperiodol withdrawal the number of specific somatostatin receptors in both brain areas returned to control values, after having decreased as the result of chronic administration. Neither administration of haloperidol nor withdrawal of it affected the levels of somatostatin-like immunoreactivity (SLI) in the two brain areas studied. The return of the somatostatin receptor number to control values after haloperidol withdrawal may be related to the motor side-effects that are clinically observed when the haloperidol treatment is terminated. SN - 0144-8463 UR - https://www.unboundmedicine.com/medline/citation/1971188/Effect_of_haloperidol_withdrawal_on_somatostatin_level_and_binding_in_rat_brain_ DB - PRIME DP - Unbound Medicine ER -