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Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats.
Eur J Neurosci. 2009 Sep; 30(5):901-12.EJ

Abstract

Exposure to a cocaine-paired context increases the propensity for relapse in cocaine users and prompts cocaine-seeking behavior in rats. According to the reconsolidation hypothesis, upon context re-exposure, established cocaine-related associations are retrieved and can become labile. These associations must undergo reconsolidation into long-term memory to effect enduring stimulus control. The dorsal hippocampus (DH), dorsolateral caudate-putamen and dorsomedial prefrontal cortex are critical for the expression of context-induced cocaine seeking, and these brain regions may also play a role in the reconsolidation of cocaine-related memories that promote this behavior. To test this hypothesis, rats were trained to press a lever for unsignaled cocaine infusions (0.2 mg/infusion, i.v.) in a distinct environmental context (cocaine-paired context), followed by extinction training in a different context (extinction context). Rats were then re-exposed to the cocaine-paired context for 15 min in order to reactivate cocaine-related memories or received comparable exposure to a novel unpaired context. Immediately thereafter, rats received bilateral microinfusions of the protein synthesis inhibitor anisomycin, the sodium channel blocker tetrodotoxin or vehicle into one of the above brain regions. After additional extinction training in the extinction context, reinstatement of cocaine-seeking behavior (i.e., non-reinforced lever presses) was assessed in the cocaine-paired context. Tetrodotoxin, but not anisomycin, administered into the DH inhibited drug context-induced cocaine-seeking behavior in a memory reactivation-dependent manner. Other manipulations failed to alter this behavior. These findings suggest that the DH facilitates the reconsolidation of associative memories that maintain context-induced cocaine-seeking behavior, but it is not the site of anisomycin-sensitive memory restabilization per se.

Authors+Show Affiliations

Department of Psychology, University of North Carolina, Chapel Hill, NC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19712098

Citation

Ramirez, Donna R., et al. "Dorsal Hippocampal Regulation of Memory Reconsolidation Processes That Facilitate Drug Context-induced Cocaine-seeking Behavior in Rats." The European Journal of Neuroscience, vol. 30, no. 5, 2009, pp. 901-12.
Ramirez DR, Bell GH, Lasseter HC, et al. Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats. Eur J Neurosci. 2009;30(5):901-12.
Ramirez, D. R., Bell, G. H., Lasseter, H. C., Xie, X., Traina, S. A., & Fuchs, R. A. (2009). Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats. The European Journal of Neuroscience, 30(5), 901-12. https://doi.org/10.1111/j.1460-9568.2009.06889.x
Ramirez DR, et al. Dorsal Hippocampal Regulation of Memory Reconsolidation Processes That Facilitate Drug Context-induced Cocaine-seeking Behavior in Rats. Eur J Neurosci. 2009;30(5):901-12. PubMed PMID: 19712098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats. AU - Ramirez,Donna R, AU - Bell,Guinevere H, AU - Lasseter,Heather C, AU - Xie,Xiaou, AU - Traina,Stephanie A, AU - Fuchs,Rita A, Y1 - 2009/08/27/ PY - 2009/8/29/entrez PY - 2009/8/29/pubmed PY - 2009/11/18/medline SP - 901 EP - 12 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 30 IS - 5 N2 - Exposure to a cocaine-paired context increases the propensity for relapse in cocaine users and prompts cocaine-seeking behavior in rats. According to the reconsolidation hypothesis, upon context re-exposure, established cocaine-related associations are retrieved and can become labile. These associations must undergo reconsolidation into long-term memory to effect enduring stimulus control. The dorsal hippocampus (DH), dorsolateral caudate-putamen and dorsomedial prefrontal cortex are critical for the expression of context-induced cocaine seeking, and these brain regions may also play a role in the reconsolidation of cocaine-related memories that promote this behavior. To test this hypothesis, rats were trained to press a lever for unsignaled cocaine infusions (0.2 mg/infusion, i.v.) in a distinct environmental context (cocaine-paired context), followed by extinction training in a different context (extinction context). Rats were then re-exposed to the cocaine-paired context for 15 min in order to reactivate cocaine-related memories or received comparable exposure to a novel unpaired context. Immediately thereafter, rats received bilateral microinfusions of the protein synthesis inhibitor anisomycin, the sodium channel blocker tetrodotoxin or vehicle into one of the above brain regions. After additional extinction training in the extinction context, reinstatement of cocaine-seeking behavior (i.e., non-reinforced lever presses) was assessed in the cocaine-paired context. Tetrodotoxin, but not anisomycin, administered into the DH inhibited drug context-induced cocaine-seeking behavior in a memory reactivation-dependent manner. Other manipulations failed to alter this behavior. These findings suggest that the DH facilitates the reconsolidation of associative memories that maintain context-induced cocaine-seeking behavior, but it is not the site of anisomycin-sensitive memory restabilization per se. SN - 1460-9568 UR - https://www.unboundmedicine.com/medline/citation/19712098/Dorsal_hippocampal_regulation_of_memory_reconsolidation_processes_that_facilitate_drug_context_induced_cocaine_seeking_behavior_in_rats_ L2 - https://doi.org/10.1111/j.1460-9568.2009.06889.x DB - PRIME DP - Unbound Medicine ER -