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5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents.
Eur J Pharmacol. 1990 Feb 20; 177(1-2):95-8.EJ

Abstract

This study examined the [3H]5-HT-releasing properties of 3,4-methylenedioxymethamphetamine (MDMA) and related agents, all of which cause significant release of [3H]5-HT from rat brain synaptosomes. 5-HT uptake blockers dose dependently block MDMA-induced [3H]5-HT release. The EC50s of the uptake drugs in blocking MDMA-induced release correlate with their affinity for the 5-HT uptake site labeled by [3H]paroxetine (r = 0.98; P less than 0.01). These data demonstrate that the 5-HT uptake carrier plays a significant role in the release of 5-HT induced by MDMA and related agents.

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Publisher Full Text

Authors+Show Affiliations

Hekmatpanah CR
Department of Neurology, Stanford University Medical Center, CA 94305.
Peroutka SJ
No affiliation info available

MeSH

3,4-MethylenedioxyamphetamineAmphetaminesAnimalsBrain ChemistryIn Vitro TechniquesMaleN-Methyl-3,4-methylenedioxyamphetamineParoxetinePiperidinesRatsRats, Inbred StrainsSerotoninSerotonin AntagonistsSynaptosomes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1971219

Citation

Hekmatpanah, C R., and S J. Peroutka. "5-hydroxytryptamine Uptake Blockers Attenuate the 5-hydroxytryptamine-releasing Effect of 3,4-methylenedioxymethamphetamine and Related Agents." European Journal of Pharmacology, vol. 177, no. 1-2, 1990, pp. 95-8.
Hekmatpanah CR, Peroutka SJ. 5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents. Eur J Pharmacol. 1990;177(1-2):95-8.
Hekmatpanah, C. R., & Peroutka, S. J. (1990). 5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents. European Journal of Pharmacology, 177(1-2), 95-8.
Hekmatpanah CR, Peroutka SJ. 5-hydroxytryptamine Uptake Blockers Attenuate the 5-hydroxytryptamine-releasing Effect of 3,4-methylenedioxymethamphetamine and Related Agents. Eur J Pharmacol. 1990 Feb 20;177(1-2):95-8. PubMed PMID: 1971219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents. AU - Hekmatpanah,C R, AU - Peroutka,S J, PY - 1990/2/20/pubmed PY - 1990/2/20/medline PY - 1990/2/20/entrez SP - 95 EP - 8 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 177 IS - 1-2 N2 - This study examined the [3H]5-HT-releasing properties of 3,4-methylenedioxymethamphetamine (MDMA) and related agents, all of which cause significant release of [3H]5-HT from rat brain synaptosomes. 5-HT uptake blockers dose dependently block MDMA-induced [3H]5-HT release. The EC50s of the uptake drugs in blocking MDMA-induced release correlate with their affinity for the 5-HT uptake site labeled by [3H]paroxetine (r = 0.98; P less than 0.01). These data demonstrate that the 5-HT uptake carrier plays a significant role in the release of 5-HT induced by MDMA and related agents. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/1971219/5_hydroxytryptamine_uptake_blockers_attenuate_the_5_hydroxytryptamine_releasing_effect_of_34_methylenedioxymethamphetamine_and_related_agents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(90)90555-K DB - PRIME DP - Unbound Medicine ER -