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Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance.
Lipids Health Dis. 2009 Aug 27; 8:37.LH

Abstract

Fatty acid composition of serum lipids and adipose tissue triacylglycerols (AT-TAG) partly reflect dietary fatty acid intake. The fatty acid composition is, besides the diet, also influenced by desaturating enzymes that can be estimated using product-to-precursor fatty acid ratios. The interrelationships between desaturase indices derived from different serum lipid fractions and adipose tissue are unclear, as well as their associations with obesity and insulin resistance. We aimed to investigate cross-sectional correlations between desaturase indices as measured in serum lipid fractions (phospholipids; PL and free fatty acids; FFA) and in adipose tissue (AT-TAG). In a population-based sample of 301 healthy 60-year-old men various desaturase indices were assessed: stearoyl-CoA-desaturase (16:1n-7/16:0; SCD-16 and 18:1n-9/18:0; SCD-18, respectively), delta-6-desaturase (20:3n-6/18:2n-6; D6D) and delta-5-desaturase (20:4n-6/20:3n-6; D5D). Correlations with BMI and insulin resistance (HOMA-IR) were also examined. SCD-16 and D5D were significantly correlated between fractions and tissues (all r > 0.30), whereas SCD-18 and D6D were not. Desaturase indices in serum FFA and AT-TAG were significantly correlated; SCD-16 (r = 0.63), SCD-18 (r = 0.37), and D5D (r = 0.43). In phospholipids, SCD-16 was positively correlated to BMI (r = 0.15), while D5D negatively to both BMI (r = -0.30) and HOMA-IR (r = -0.31), all p < 0.01. D6D in both phospholipids and AT-TAG was positively correlated to HOMA-IR and BMI (all p < 0.01). In conclusion, SCD-1 and D5D activity indices showed overall strong correlations between lipid pools. SCD-1 activity index in adipose tissue is best reflected by 16:1/16:0-ratio in serum FFA, but associations with obesity and insulin resistance differ between these pools. D5D in PL was inversely related to obesity and insulin resistance, whereas D6D index showed positive associations.

Authors+Show Affiliations

Department of Public Health and Caring Sciences, Clinical nutrition and metabolism, Uppsala University, Uppsala, Sweden. eva.warensjo@pubcare.uu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19712485

Citation

Warensjö, Eva, et al. "Associations Between Estimated Fatty Acid Desaturase Activities in Serum Lipids and Adipose Tissue in Humans: Links to Obesity and Insulin Resistance." Lipids in Health and Disease, vol. 8, 2009, p. 37.
Warensjö E, Rosell M, Hellenius ML, et al. Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance. Lipids Health Dis. 2009;8:37.
Warensjö, E., Rosell, M., Hellenius, M. L., Vessby, B., De Faire, U., & Risérus, U. (2009). Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance. Lipids in Health and Disease, 8, 37. https://doi.org/10.1186/1476-511X-8-37
Warensjö E, et al. Associations Between Estimated Fatty Acid Desaturase Activities in Serum Lipids and Adipose Tissue in Humans: Links to Obesity and Insulin Resistance. Lipids Health Dis. 2009 Aug 27;8:37. PubMed PMID: 19712485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance. AU - Warensjö,Eva, AU - Rosell,Magdalena, AU - Hellenius,Mai-Lis, AU - Vessby,Bengt, AU - De Faire,Ulf, AU - Risérus,Ulf, Y1 - 2009/08/27/ PY - 2009/06/29/received PY - 2009/08/27/accepted PY - 2009/8/29/entrez PY - 2009/8/29/pubmed PY - 2009/12/16/medline SP - 37 EP - 37 JF - Lipids in health and disease JO - Lipids Health Dis VL - 8 N2 - Fatty acid composition of serum lipids and adipose tissue triacylglycerols (AT-TAG) partly reflect dietary fatty acid intake. The fatty acid composition is, besides the diet, also influenced by desaturating enzymes that can be estimated using product-to-precursor fatty acid ratios. The interrelationships between desaturase indices derived from different serum lipid fractions and adipose tissue are unclear, as well as their associations with obesity and insulin resistance. We aimed to investigate cross-sectional correlations between desaturase indices as measured in serum lipid fractions (phospholipids; PL and free fatty acids; FFA) and in adipose tissue (AT-TAG). In a population-based sample of 301 healthy 60-year-old men various desaturase indices were assessed: stearoyl-CoA-desaturase (16:1n-7/16:0; SCD-16 and 18:1n-9/18:0; SCD-18, respectively), delta-6-desaturase (20:3n-6/18:2n-6; D6D) and delta-5-desaturase (20:4n-6/20:3n-6; D5D). Correlations with BMI and insulin resistance (HOMA-IR) were also examined. SCD-16 and D5D were significantly correlated between fractions and tissues (all r > 0.30), whereas SCD-18 and D6D were not. Desaturase indices in serum FFA and AT-TAG were significantly correlated; SCD-16 (r = 0.63), SCD-18 (r = 0.37), and D5D (r = 0.43). In phospholipids, SCD-16 was positively correlated to BMI (r = 0.15), while D5D negatively to both BMI (r = -0.30) and HOMA-IR (r = -0.31), all p < 0.01. D6D in both phospholipids and AT-TAG was positively correlated to HOMA-IR and BMI (all p < 0.01). In conclusion, SCD-1 and D5D activity indices showed overall strong correlations between lipid pools. SCD-1 activity index in adipose tissue is best reflected by 16:1/16:0-ratio in serum FFA, but associations with obesity and insulin resistance differ between these pools. D5D in PL was inversely related to obesity and insulin resistance, whereas D6D index showed positive associations. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/19712485/Associations_between_estimated_fatty_acid_desaturase_activities_in_serum_lipids_and_adipose_tissue_in_humans:_links_to_obesity_and_insulin_resistance_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-8-37 DB - PRIME DP - Unbound Medicine ER -