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Differentiation between mild cognitive impairment and Alzheimer's disease using the FMLL mini-battery.
Dement Geriatr Cogn Disord 2009; 28(2):179-86DG

Abstract

AIM

To construct and validate a mini-battery to discriminate between Alzheimer's disease (AD) and mild cognitive impairment (MCI) in patients seen at a hospital memory clinic.

METHODS

In a cohort of 310 subjects (137 with MCI and 173 with AD), the area under the receiver operating curve (AUC) was used to select the neuropsychologic diagnostic test battery subtests with the best overall performance, namely, the Mini-Mental State Examination (MMSE, 0.715), Logical Memory II (LMII, 0.721), Verbal Fluency Test (0.747), and Lawton index (0.742). A mini-battery test was constructed with the following formulation: FMLL = [(Fluency Test/17 + MMSE/30 + LMII/32 + Lawton/8)/4] x 100. Another cohort of 87 subjects with MCI and 100 with AD was used to validate the mini-battery and to calculate the psychometric properties.

RESULTS

The concurrent validity with Reisberg's Global Deterioration Scale was r = 0.792 (p < 0.001). Cronbach's alpha internal consistency was 0.6358. The AUC to diagnose MCI or AD was 0.879 (95% CI: 0.832-0.927; p < 0.001). Specificity for MCI diagnosis was 0.9 when FMLL scores were above 59% and 1 when scores were above 76%.

CONCLUSION

The FMLL mini-examination is a useful tool to differentiate between MCI and AD in patients seen in a memory clinic.

Authors+Show Affiliations

Geriatrics Department, Complejo Hospitalario Universitario of Albacete, Albacete, Spain. pabizanda@sescam.jccm.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

19713701

Citation

Abizanda, Pedro, et al. "Differentiation Between Mild Cognitive Impairment and Alzheimer's Disease Using the FMLL Mini-battery." Dementia and Geriatric Cognitive Disorders, vol. 28, no. 2, 2009, pp. 179-86.
Abizanda P, López-Ramos B, Romero L, et al. Differentiation between mild cognitive impairment and Alzheimer's disease using the FMLL mini-battery. Dement Geriatr Cogn Disord. 2009;28(2):179-86.
Abizanda, P., López-Ramos, B., Romero, L., Sánchez-Jurado, P. M., León, M., Martín-Sebastiá, E., & López-Jiménez, E. (2009). Differentiation between mild cognitive impairment and Alzheimer's disease using the FMLL mini-battery. Dementia and Geriatric Cognitive Disorders, 28(2), pp. 179-86. doi:10.1159/000235797.
Abizanda P, et al. Differentiation Between Mild Cognitive Impairment and Alzheimer's Disease Using the FMLL Mini-battery. Dement Geriatr Cogn Disord. 2009;28(2):179-86. PubMed PMID: 19713701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differentiation between mild cognitive impairment and Alzheimer's disease using the FMLL mini-battery. AU - Abizanda,Pedro, AU - López-Ramos,Beatriz, AU - Romero,Luis, AU - Sánchez-Jurado,Pedro Manuel, AU - León,Matilde, AU - Martín-Sebastiá,Elena, AU - López-Jiménez,Esther, Y1 - 2009/08/28/ PY - 2009/06/26/accepted PY - 2009/8/29/entrez PY - 2009/8/29/pubmed PY - 2009/11/18/medline SP - 179 EP - 86 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 28 IS - 2 N2 - AIM: To construct and validate a mini-battery to discriminate between Alzheimer's disease (AD) and mild cognitive impairment (MCI) in patients seen at a hospital memory clinic. METHODS: In a cohort of 310 subjects (137 with MCI and 173 with AD), the area under the receiver operating curve (AUC) was used to select the neuropsychologic diagnostic test battery subtests with the best overall performance, namely, the Mini-Mental State Examination (MMSE, 0.715), Logical Memory II (LMII, 0.721), Verbal Fluency Test (0.747), and Lawton index (0.742). A mini-battery test was constructed with the following formulation: FMLL = [(Fluency Test/17 + MMSE/30 + LMII/32 + Lawton/8)/4] x 100. Another cohort of 87 subjects with MCI and 100 with AD was used to validate the mini-battery and to calculate the psychometric properties. RESULTS: The concurrent validity with Reisberg's Global Deterioration Scale was r = 0.792 (p < 0.001). Cronbach's alpha internal consistency was 0.6358. The AUC to diagnose MCI or AD was 0.879 (95% CI: 0.832-0.927; p < 0.001). Specificity for MCI diagnosis was 0.9 when FMLL scores were above 59% and 1 when scores were above 76%. CONCLUSION: The FMLL mini-examination is a useful tool to differentiate between MCI and AD in patients seen in a memory clinic. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/19713701/Differentiation_between_mild_cognitive_impairment_and_Alzheimer's_disease_using_the_FMLL_mini_battery_ L2 - https://www.karger.com?DOI=10.1159/000235797 DB - PRIME DP - Unbound Medicine ER -