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Factors related to clinically probable REM sleep behavior disorder in Parkinson disease.
Parkinsonism Relat Disord. 2010 Feb; 16(2):105-8.PR

Abstract

Rapid eye movement sleep behavior disorder (RBD) is commonly accompanied in Parkinson disease (PD). However, the underlying mechanism linking RBD to PD remains unclear. We interviewed and examined 447 consecutive patients with PD to investigate factors associated with the presence of RBD in PD patients. Using the minimal diagnostic criteria for parasomnias provided in the International Classification of Sleep Disorders-Revised (ICSD-R), 164 patients (36.5%) were diagnosed with clinically probable RBD (cpRBD). PD patients with cpRBD were older, had a longer duration of PD, a more severe level of disability, a longer duration of antiparkinsonian medication, and a lower proportion of their Unified Parkinson Disease Rating Scale (UPDRS) scores accounted for by tremor than those without RBD. Multivariate and univariate logistic regression analyses revealed that patient age, PD symptom duration (and, accordingly, more severe motor disability), tremor score, and proportion of the UPDRS score accounted for by tremor were significant factors associated with the presence of RBD in PD patients. The results of the present study support previous observations that PD with RBD may result from a different underlying pattern of neurodegeneration than PD without RBD.

Authors+Show Affiliations

Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19716333

Citation

Lee, Ji E., et al. "Factors Related to Clinically Probable REM Sleep Behavior Disorder in Parkinson Disease." Parkinsonism & Related Disorders, vol. 16, no. 2, 2010, pp. 105-8.
Lee JE, Kim KS, Shin HW, et al. Factors related to clinically probable REM sleep behavior disorder in Parkinson disease. Parkinsonism Relat Disord. 2010;16(2):105-8.
Lee, J. E., Kim, K. S., Shin, H. W., & Sohn, Y. H. (2010). Factors related to clinically probable REM sleep behavior disorder in Parkinson disease. Parkinsonism & Related Disorders, 16(2), 105-8. https://doi.org/10.1016/j.parkreldis.2009.08.005
Lee JE, et al. Factors Related to Clinically Probable REM Sleep Behavior Disorder in Parkinson Disease. Parkinsonism Relat Disord. 2010;16(2):105-8. PubMed PMID: 19716333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors related to clinically probable REM sleep behavior disorder in Parkinson disease. AU - Lee,Ji E, AU - Kim,Kyung S, AU - Shin,Hae-Won, AU - Sohn,Young H, Y1 - 2009/08/27/ PY - 2009/04/29/received PY - 2009/08/11/revised PY - 2009/08/12/accepted PY - 2009/9/1/entrez PY - 2009/9/1/pubmed PY - 2010/5/5/medline SP - 105 EP - 8 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 16 IS - 2 N2 - Rapid eye movement sleep behavior disorder (RBD) is commonly accompanied in Parkinson disease (PD). However, the underlying mechanism linking RBD to PD remains unclear. We interviewed and examined 447 consecutive patients with PD to investigate factors associated with the presence of RBD in PD patients. Using the minimal diagnostic criteria for parasomnias provided in the International Classification of Sleep Disorders-Revised (ICSD-R), 164 patients (36.5%) were diagnosed with clinically probable RBD (cpRBD). PD patients with cpRBD were older, had a longer duration of PD, a more severe level of disability, a longer duration of antiparkinsonian medication, and a lower proportion of their Unified Parkinson Disease Rating Scale (UPDRS) scores accounted for by tremor than those without RBD. Multivariate and univariate logistic regression analyses revealed that patient age, PD symptom duration (and, accordingly, more severe motor disability), tremor score, and proportion of the UPDRS score accounted for by tremor were significant factors associated with the presence of RBD in PD patients. The results of the present study support previous observations that PD with RBD may result from a different underlying pattern of neurodegeneration than PD without RBD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/19716333/Factors_related_to_clinically_probable_REM_sleep_behavior_disorder_in_Parkinson_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(09)00214-4 DB - PRIME DP - Unbound Medicine ER -