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Evidence of anti-inflammatory effects of pioglitazone in the murine pleurisy model induced by carrageenan.
Int Immunopharmacol. 2009 Nov; 9(12):1394-400.II

Abstract

Several studies have shown that the anti-inflammatory effect of Pioglitazone extends beyond the cardiovascular system. This study examines the anti-inflammatory effect of Pioglitazone in comparison to reference drugs (Dexamethasone and Indomethacin) in the mouse model of pleurisy induced by carrageenan which is characterized by two distinct phases (4 and 48 h) of inflammation. Pioglitazone (20 and 50 mg/kg, i.p., 0.5 h before pleurisy) inhibited both neutrophil (4 h) and mononuclears (48 h) influxes (P<0.01), but not exudation (P>0.05). While one dose of Pioglitazone was effective in inhibiting inflammation at 4 h, additional doses (10 or 20 mg/kg, i.p., 0.5 h before pleurisy induction followed by either a second dose at 24 h after the first one or two further doses at 12 h of time interval after the first one) were necessary to elicit inhibition of the second (48 h) inflammation phase. These effects were associated with a marked decrease in adenosine-deaminase (ADA) activity, tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-beta (IL-1beta) levels (P<0.01). Myeloperoxidade (MPO) activity was inhibited only at 4 h (P<0.05). By contrast, reference drugs were able to inhibit all the studied inflammatory parameters (P<0.05). These results demonstrated an interesting anti-inflammatory property of this thiazolidinedione class and strengthen prior evidence that PPAR pathways constitute another important route of inflammatory process inhibition of this pleurisy model.

Authors+Show Affiliations

Departamento de Análises Clínicas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. saleh@ccs.ufsc.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19716439

Citation

Fröde, Tânia Silvia, et al. "Evidence of Anti-inflammatory Effects of Pioglitazone in the Murine Pleurisy Model Induced By Carrageenan." International Immunopharmacology, vol. 9, no. 12, 2009, pp. 1394-400.
Fröde TS, Buss Zda S, dos Reis GO, et al. Evidence of anti-inflammatory effects of pioglitazone in the murine pleurisy model induced by carrageenan. Int Immunopharmacol. 2009;9(12):1394-400.
Fröde, T. S., Buss, Z. d. a. . S., dos Reis, G. O., & Medeiros, Y. S. (2009). Evidence of anti-inflammatory effects of pioglitazone in the murine pleurisy model induced by carrageenan. International Immunopharmacology, 9(12), 1394-400. https://doi.org/10.1016/j.intimp.2009.08.011
Fröde TS, et al. Evidence of Anti-inflammatory Effects of Pioglitazone in the Murine Pleurisy Model Induced By Carrageenan. Int Immunopharmacol. 2009;9(12):1394-400. PubMed PMID: 19716439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of anti-inflammatory effects of pioglitazone in the murine pleurisy model induced by carrageenan. AU - Fröde,Tânia Silvia, AU - Buss,Ziliani da Silva, AU - dos Reis,Gustavo Oliveira, AU - Medeiros,Yara Santos, Y1 - 2009/08/28/ PY - 2009/02/26/received PY - 2009/08/07/revised PY - 2009/08/19/accepted PY - 2009/9/1/entrez PY - 2009/9/1/pubmed PY - 2010/5/19/medline SP - 1394 EP - 400 JF - International immunopharmacology JO - Int Immunopharmacol VL - 9 IS - 12 N2 - Several studies have shown that the anti-inflammatory effect of Pioglitazone extends beyond the cardiovascular system. This study examines the anti-inflammatory effect of Pioglitazone in comparison to reference drugs (Dexamethasone and Indomethacin) in the mouse model of pleurisy induced by carrageenan which is characterized by two distinct phases (4 and 48 h) of inflammation. Pioglitazone (20 and 50 mg/kg, i.p., 0.5 h before pleurisy) inhibited both neutrophil (4 h) and mononuclears (48 h) influxes (P<0.01), but not exudation (P>0.05). While one dose of Pioglitazone was effective in inhibiting inflammation at 4 h, additional doses (10 or 20 mg/kg, i.p., 0.5 h before pleurisy induction followed by either a second dose at 24 h after the first one or two further doses at 12 h of time interval after the first one) were necessary to elicit inhibition of the second (48 h) inflammation phase. These effects were associated with a marked decrease in adenosine-deaminase (ADA) activity, tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-beta (IL-1beta) levels (P<0.01). Myeloperoxidade (MPO) activity was inhibited only at 4 h (P<0.05). By contrast, reference drugs were able to inhibit all the studied inflammatory parameters (P<0.05). These results demonstrated an interesting anti-inflammatory property of this thiazolidinedione class and strengthen prior evidence that PPAR pathways constitute another important route of inflammatory process inhibition of this pleurisy model. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/19716439/Evidence_of_anti_inflammatory_effects_of_pioglitazone_in_the_murine_pleurisy_model_induced_by_carrageenan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(09)00252-5 DB - PRIME DP - Unbound Medicine ER -