Tags

Type your tag names separated by a space and hit enter

Does the presence of polycystic ovary syndrome increase the risk of obstetrical complications in women with gestational diabetes?
J Matern Fetal Neonatal Med 2010; 23(6):545-9JM

Abstract

OBJECTIVE

To determine whether women with both polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) have an increased risk of obstetric complications compared with women with GDM alone.

METHODS

A retrospective cohort study of maternal/fetal outcomes in women with GDM and PCOS was compared with women with GDM alone. Outcomes were compared using Fisher's exact test for categorical variables and t-test for continuous variables. Logistic regression models allowed for the calculation of odds ratios and 95% confidence intervals (CIs) for each outcome, adjusted for confounding.

RESULTS

One hundred seventy one women were included in the study. Significantly more women with both GDM and PCOS had pregnancy-induced hypertension/preeclampsia (15.9% vs. 3.9%, p = 0.019, OR = 4.62, 95% CI = 1.38-15.41). Multiple logistic regression revealed that this increase persisted after controlling for body mass index (p = 0.028, OR = 4.43, 95% CI = 1.17-16.72) and parity (p = 0.050, OR = 3.45, 95% CI = 1.00-11.92). Women with GDM and PCOS tended to have more preterm deliveries (25.0% vs. 11.8%, p = 0.063). More infants of women with GDM and PCOS required phototherapy treatment for hyperbilirubinemia (25.0% vs. 7.9%, p = 0.0066, OR = 3.90, 95% CI = 1.52-9.98). Logistic regression revealed that this association persisted after controlling for preterm delivery (OR = 3.18, 95% CI = 1.14-8.82, p = 0.026).

CONCLUSIONS

Mothers with both disorders should be monitored more carefully and counseled regarding their increased risk of both maternal and fetal complications.

Authors+Show Affiliations

Department of Medicine, Mubarak Al-Kabeer Hospital, Kuwait.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19718584

Citation

Alshammari, Abdulmuhsen, et al. "Does the Presence of Polycystic Ovary Syndrome Increase the Risk of Obstetrical Complications in Women With Gestational Diabetes?" The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 23, no. 6, 2010, pp. 545-9.
Alshammari A, Hanley A, Ni A, et al. Does the presence of polycystic ovary syndrome increase the risk of obstetrical complications in women with gestational diabetes? J Matern Fetal Neonatal Med. 2010;23(6):545-9.
Alshammari, A., Hanley, A., Ni, A., Tomlinson, G., & Feig, D. S. (2010). Does the presence of polycystic ovary syndrome increase the risk of obstetrical complications in women with gestational diabetes? The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 23(6), pp. 545-9. doi:10.3109/14767050903214566.
Alshammari A, et al. Does the Presence of Polycystic Ovary Syndrome Increase the Risk of Obstetrical Complications in Women With Gestational Diabetes. J Matern Fetal Neonatal Med. 2010;23(6):545-9. PubMed PMID: 19718584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does the presence of polycystic ovary syndrome increase the risk of obstetrical complications in women with gestational diabetes? AU - Alshammari,Abdulmuhsen, AU - Hanley,Anthony, AU - Ni,Andrew, AU - Tomlinson,George, AU - Feig,Denice S, PY - 2009/9/1/entrez PY - 2009/9/1/pubmed PY - 2010/9/2/medline SP - 545 EP - 9 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. VL - 23 IS - 6 N2 - OBJECTIVE: To determine whether women with both polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) have an increased risk of obstetric complications compared with women with GDM alone. METHODS: A retrospective cohort study of maternal/fetal outcomes in women with GDM and PCOS was compared with women with GDM alone. Outcomes were compared using Fisher's exact test for categorical variables and t-test for continuous variables. Logistic regression models allowed for the calculation of odds ratios and 95% confidence intervals (CIs) for each outcome, adjusted for confounding. RESULTS: One hundred seventy one women were included in the study. Significantly more women with both GDM and PCOS had pregnancy-induced hypertension/preeclampsia (15.9% vs. 3.9%, p = 0.019, OR = 4.62, 95% CI = 1.38-15.41). Multiple logistic regression revealed that this increase persisted after controlling for body mass index (p = 0.028, OR = 4.43, 95% CI = 1.17-16.72) and parity (p = 0.050, OR = 3.45, 95% CI = 1.00-11.92). Women with GDM and PCOS tended to have more preterm deliveries (25.0% vs. 11.8%, p = 0.063). More infants of women with GDM and PCOS required phototherapy treatment for hyperbilirubinemia (25.0% vs. 7.9%, p = 0.0066, OR = 3.90, 95% CI = 1.52-9.98). Logistic regression revealed that this association persisted after controlling for preterm delivery (OR = 3.18, 95% CI = 1.14-8.82, p = 0.026). CONCLUSIONS: Mothers with both disorders should be monitored more carefully and counseled regarding their increased risk of both maternal and fetal complications. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/19718584/Does_the_presence_of_polycystic_ovary_syndrome_increase_the_risk_of_obstetrical_complications_in_women_with_gestational_diabetes L2 - http://www.tandfonline.com/doi/full/10.3109/14767050903214566 DB - PRIME DP - Unbound Medicine ER -