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Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities.
J Pharm Sci. 2010 Mar; 99(3):1225-38.JP

Abstract

The aim of the study was to determine and compare the degree of swelling and the swelling kinetics of poly(ethylene oxide) (PEO) hydrophilic matrix tablets without any additives for matrixes with different molecular weight polydispersities. A wide range of "mixed" polydisperse PEO tablets were obtained by mixing two PEO batches with average molecular weights of 10(5) and 2 x 10(6), respectively. These were compared with "single-batch" tablets with narrower mono-modal molecular weight distributions. A texture analyzer (TA) was used to determine, during the entire dissolution process, the thickness of the "gel" layer, the height of the dry tablet core and the total height of the tablet. The release of polymer from the tablet was also measured using a chromatographic method. Both the swelling histories and the polymer release rates varied strongly with molecular weight and agitation rate, whereas the rate of dissolution of the solid core varied much less with molecular weight. For single-batch and mixed tablets, tuned to give the same release rate, the swelling process was found to be very similar, regardless of the molecular polydispersity (between 1.2 and 8.8). These results support a previously proposed dissolution model with the key assumption of a constant critical viscosity, independent of time or polymer molecular weight, at the surface of the gel layer of a dissolving tablet.

Links

Publisher Full Text
linkinghub.elsevier.com
onlinelibrary.wiley.com

Authors+Show Affiliations

Körner A
Department of Physical Chemistry 1, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.
Larsson A
No affiliation info available
Andersson A
No affiliation info available
Piculell L
No affiliation info available

MeSH

Chemical PhenomenaDrug CompoundingMolecular WeightPolyethylene GlycolsSolubilityTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19718760

Citation

Körner, Anna, et al. "Swelling and Polymer Erosion for Poly(ethylene Oxide) Tablets of Different Molecular Weights Polydispersities." Journal of Pharmaceutical Sciences, vol. 99, no. 3, 2010, pp. 1225-38.
Körner A, Larsson A, Andersson A, et al. Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities. J Pharm Sci. 2010;99(3):1225-38.
Körner, A., Larsson, A., Andersson, A., & Piculell, L. (2010). Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities. Journal of Pharmaceutical Sciences, 99(3), 1225-38. https://doi.org/10.1002/jps.21892
Körner A, et al. Swelling and Polymer Erosion for Poly(ethylene Oxide) Tablets of Different Molecular Weights Polydispersities. J Pharm Sci. 2010;99(3):1225-38. PubMed PMID: 19718760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities. AU - Körner,Anna, AU - Larsson,Anette, AU - Andersson,Asa, AU - Piculell,Lennart, PY - 2009/9/1/entrez PY - 2009/9/1/pubmed PY - 2010/4/3/medline SP - 1225 EP - 38 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 99 IS - 3 N2 - The aim of the study was to determine and compare the degree of swelling and the swelling kinetics of poly(ethylene oxide) (PEO) hydrophilic matrix tablets without any additives for matrixes with different molecular weight polydispersities. A wide range of "mixed" polydisperse PEO tablets were obtained by mixing two PEO batches with average molecular weights of 10(5) and 2 x 10(6), respectively. These were compared with "single-batch" tablets with narrower mono-modal molecular weight distributions. A texture analyzer (TA) was used to determine, during the entire dissolution process, the thickness of the "gel" layer, the height of the dry tablet core and the total height of the tablet. The release of polymer from the tablet was also measured using a chromatographic method. Both the swelling histories and the polymer release rates varied strongly with molecular weight and agitation rate, whereas the rate of dissolution of the solid core varied much less with molecular weight. For single-batch and mixed tablets, tuned to give the same release rate, the swelling process was found to be very similar, regardless of the molecular polydispersity (between 1.2 and 8.8). These results support a previously proposed dissolution model with the key assumption of a constant critical viscosity, independent of time or polymer molecular weight, at the surface of the gel layer of a dissolving tablet. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/19718760/Swelling_and_polymer_erosion_for_poly_ethylene_oxide__tablets_of_different_molecular_weights_polydispersities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(15)32724-6 DB - PRIME DP - Unbound Medicine ER -