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A conjunctival lesion with histological features similar to large-cell acanthoma of the skin.
J Cutan Pathol. 2010 Oct; 37(10):1103-6.JC

Abstract

Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential.

Authors+Show Affiliations

Department of Ophthalmology The University of Virginia Health System, Charlottesville, Virginia, USA. ngg6f@virginia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19719831

Citation

Ghazi, Nicola G., et al. "A Conjunctival Lesion With Histological Features Similar to Large-cell Acanthoma of the Skin." Journal of Cutaneous Pathology, vol. 37, no. 10, 2010, pp. 1103-6.
Ghazi NG, Patel BS, Olsakovsky LA, et al. A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. J Cutan Pathol. 2010;37(10):1103-6.
Ghazi, N. G., Patel, B. S., Olsakovsky, L. A., White, K., Patterson, J. W., & Carter, B. (2010). A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. Journal of Cutaneous Pathology, 37(10), 1103-6. https://doi.org/10.1111/j.1600-0560.2009.01409.x
Ghazi NG, et al. A Conjunctival Lesion With Histological Features Similar to Large-cell Acanthoma of the Skin. J Cutan Pathol. 2010;37(10):1103-6. PubMed PMID: 19719831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A conjunctival lesion with histological features similar to large-cell acanthoma of the skin. AU - Ghazi,Nicola G, AU - Patel,Bina S, AU - Olsakovsky,Leslie A, AU - White,Kevin, AU - Patterson,James W, AU - Carter,Bruce, Y1 - 2009/08/27/ PY - 2009/9/2/entrez PY - 2009/9/2/pubmed PY - 2010/12/14/medline SP - 1103 EP - 6 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 37 IS - 10 N2 - Large-cell acanthoma (LCA) is a sharply demarcated epidermal lesion composed of large keratinocytes and characterized by hyperkeratosis, hypergranulosis and orthokeratosis. It usually affects actinically damaged skin. LCA is currently believed to be a distinct entity with an unclear pathogenesis and a benign biologic behavior. Here, we describe the first occurrence of LCA in the conjunctiva. The lesion recurred following initial excision, and later recurred as a carcinoma in situ following a second excision. This case suggests that LCA may have a malignant and transformation potential. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/19719831/A_conjunctival_lesion_with_histological_features_similar_to_large_cell_acanthoma_of_the_skin_ L2 - https://doi.org/10.1111/j.1600-0560.2009.01409.x DB - PRIME DP - Unbound Medicine ER -