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n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants.
Am J Clin Nutr. 1990 Jun; 51(6):1028-34.AJ

Abstract

We compared the cardiovascular risk-reduction potential of three major polyunsaturated fatty acids in a double-blind study. Thirty-three normotensive and mildly hypercholesterolemic men were randomly allocated to one of three diets supplemented with linoleic acid (14.3 g/d), alpha-linolenic acid (9.2 g/d), or eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (3.4 g/d). Diets were matched to provide similar amounts of the major classes of fatty acids and cholesterol. Blood pressure and plasma lipids were measured for 6 wk after a 3-wk run-in period on the linoleic acid supplement. For the diet supplemented with EPA plus DHA compared with the linoleic acid diet systolic blood pressure fell 5.1 mm Hg (p = 0.01); plasma triglyceride and VLDL cholesterol fell by 39% (p = 0.001) and 49% (p = 0.01), respectively; and LDL cholesterol rose by 9% (p = 0.01). There were no significant changes with the diet supplemented with alpha-linolenic acid. The net effect on cardiovascular risk therefore is complex and the systolic blood pressure reduction was substantial.

Authors+Show Affiliations

CSIRO Division of Human Nutrition, Adelaide, South Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1971991

Citation

Kestin, M, et al. "N-3 Fatty Acids of Marine Origin Lower Systolic Blood Pressure and Triglycerides but Raise LDL Cholesterol Compared With N-3 and N-6 Fatty Acids From Plants." The American Journal of Clinical Nutrition, vol. 51, no. 6, 1990, pp. 1028-34.
Kestin M, Clifton P, Belling GB, et al. N-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. Am J Clin Nutr. 1990;51(6):1028-34.
Kestin, M., Clifton, P., Belling, G. B., & Nestel, P. J. (1990). N-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. The American Journal of Clinical Nutrition, 51(6), 1028-34.
Kestin M, et al. N-3 Fatty Acids of Marine Origin Lower Systolic Blood Pressure and Triglycerides but Raise LDL Cholesterol Compared With N-3 and N-6 Fatty Acids From Plants. Am J Clin Nutr. 1990;51(6):1028-34. PubMed PMID: 1971991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. AU - Kestin,M, AU - Clifton,P, AU - Belling,G B, AU - Nestel,P J, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 1028 EP - 34 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 51 IS - 6 N2 - We compared the cardiovascular risk-reduction potential of three major polyunsaturated fatty acids in a double-blind study. Thirty-three normotensive and mildly hypercholesterolemic men were randomly allocated to one of three diets supplemented with linoleic acid (14.3 g/d), alpha-linolenic acid (9.2 g/d), or eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) (3.4 g/d). Diets were matched to provide similar amounts of the major classes of fatty acids and cholesterol. Blood pressure and plasma lipids were measured for 6 wk after a 3-wk run-in period on the linoleic acid supplement. For the diet supplemented with EPA plus DHA compared with the linoleic acid diet systolic blood pressure fell 5.1 mm Hg (p = 0.01); plasma triglyceride and VLDL cholesterol fell by 39% (p = 0.001) and 49% (p = 0.01), respectively; and LDL cholesterol rose by 9% (p = 0.01). There were no significant changes with the diet supplemented with alpha-linolenic acid. The net effect on cardiovascular risk therefore is complex and the systolic blood pressure reduction was substantial. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/1971991/n_3_fatty_acids_of_marine_origin_lower_systolic_blood_pressure_and_triglycerides_but_raise_LDL_cholesterol_compared_with_n_3_and_n_6_fatty_acids_from_plants_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/51.6.1028 DB - PRIME DP - Unbound Medicine ER -