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Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes.
Chin Med J (Engl). 2009 Jul 05; 122(13):1539-43.CM

Abstract

BACKGROUND

Shen song Yang xin (SSYX) is a compound of Chinese medicine with the effect of increasing heart rate (HR). This study aimed to evaluate its electrophysiological properties at heart and cellular levels.

METHODS

The Chinese miniature swines were randomly assigned to two groups, administered with SSYX or placebo for 4 weeks (n = 8 per group). Cardiac electrophysiological study (EPS) was performed before and after drug administration. The guinea pig ventricular myocytes were enzymatically isolated and whole cell voltage-clamp technique was used to evaluate the effect of SSYX on cardiac action potential (AP).

RESULTS

SSYX treatment accelerated the HR from (141.8 +/- 36.0) beats per minute to (163.0 +/- 38.0) beats per minute (P = 0.013) without changing the other parameters in surface electrocardiogram. After blockage of the autonomic nervous system with metoprolol and atropin, SSYX had no effect on intrinsic HR (IHR), but decreased corrected sinus node recovery time (CSNRT) and sinus atrium conducting time (SACT). Intra cardiac EPS showed that SSYX significantly decreased the A-H and A-V intervals as well as shortened the atrial (A), atrioventricular node (AVN) and ventricular (V) effective refractory period (ERP). In isolated guinea pig ventricular myocytes, the most obvious effect of SSYX on action potential was a shortening of the action potential duration (APD) without change in shape of action potential. The shortening rates of APD(30), APD(50) and APD(90) were 19.5%, 17.8% and 15.3%, respectively. The resting potential (Em) and the interval between the end of APD(30) and APD(90) did not significantly change.

CONCLUSIONS

The present study demonstrates that SSYX increases the HR and enhances the conducting capacity of the heart in the condition of the intact autonomic nervous system. SSYX homogenously decreases the ERP of the heart and shortens the APD of the myocytes, suggesting its antiarrhythmic effect without proarrhythmia.

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Authors+Show Affiliations

Feng L
Center for Arrhythmia Diagnosis and Treatment, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.
Gong J
No affiliation info available
Jin ZY
No affiliation info available
Li N
No affiliation info available
Sun LP
No affiliation info available
Wu YL
No affiliation info available
Pu JL
No affiliation info available

MeSH

Action PotentialsAnimalsDrugs, Chinese HerbalFemaleGuinea PigsHeartHeart RateHeart VentriclesIn Vitro TechniquesMaleMyocytes, CardiacSinoatrial NodeSwineSwine, Miniature

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19719944

Citation

Feng, Li, et al. "Electrophysiological Effects of Chinese Medicine Shen Song Yang Xin (SSYX) On Chinese Miniature Swine Heart and Isolated Guinea Pig Ventricular Myocytes." Chinese Medical Journal, vol. 122, no. 13, 2009, pp. 1539-43.
Feng L, Gong J, Jin ZY, et al. Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes. Chin Med J (Engl). 2009;122(13):1539-43.
Feng, L., Gong, J., Jin, Z. Y., Li, N., Sun, L. P., Wu, Y. L., & Pu, J. L. (2009). Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes. Chinese Medical Journal, 122(13), 1539-43.
Feng L, et al. Electrophysiological Effects of Chinese Medicine Shen Song Yang Xin (SSYX) On Chinese Miniature Swine Heart and Isolated Guinea Pig Ventricular Myocytes. Chin Med J (Engl). 2009 Jul 5;122(13):1539-43. PubMed PMID: 19719944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrophysiological effects of Chinese medicine Shen song Yang xin (SSYX) on Chinese miniature swine heart and isolated guinea pig ventricular myocytes. AU - Feng,Li, AU - Gong,Jing, AU - Jin,Zhen-yi, AU - Li,Ning, AU - Sun,Li-ping, AU - Wu,Yi-ling, AU - Pu,Jie-lin, PY - 2009/9/2/entrez PY - 2009/9/2/pubmed PY - 2009/11/5/medline SP - 1539 EP - 43 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 122 IS - 13 N2 - BACKGROUND: Shen song Yang xin (SSYX) is a compound of Chinese medicine with the effect of increasing heart rate (HR). This study aimed to evaluate its electrophysiological properties at heart and cellular levels. METHODS: The Chinese miniature swines were randomly assigned to two groups, administered with SSYX or placebo for 4 weeks (n = 8 per group). Cardiac electrophysiological study (EPS) was performed before and after drug administration. The guinea pig ventricular myocytes were enzymatically isolated and whole cell voltage-clamp technique was used to evaluate the effect of SSYX on cardiac action potential (AP). RESULTS: SSYX treatment accelerated the HR from (141.8 +/- 36.0) beats per minute to (163.0 +/- 38.0) beats per minute (P = 0.013) without changing the other parameters in surface electrocardiogram. After blockage of the autonomic nervous system with metoprolol and atropin, SSYX had no effect on intrinsic HR (IHR), but decreased corrected sinus node recovery time (CSNRT) and sinus atrium conducting time (SACT). Intra cardiac EPS showed that SSYX significantly decreased the A-H and A-V intervals as well as shortened the atrial (A), atrioventricular node (AVN) and ventricular (V) effective refractory period (ERP). In isolated guinea pig ventricular myocytes, the most obvious effect of SSYX on action potential was a shortening of the action potential duration (APD) without change in shape of action potential. The shortening rates of APD(30), APD(50) and APD(90) were 19.5%, 17.8% and 15.3%, respectively. The resting potential (Em) and the interval between the end of APD(30) and APD(90) did not significantly change. CONCLUSIONS: The present study demonstrates that SSYX increases the HR and enhances the conducting capacity of the heart in the condition of the intact autonomic nervous system. SSYX homogenously decreases the ERP of the heart and shortens the APD of the myocytes, suggesting its antiarrhythmic effect without proarrhythmia. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/19719944/Electrophysiological_effects_of_Chinese_medicine_Shen_song_Yang_xin__SSYX__on_Chinese_miniature_swine_heart_and_isolated_guinea_pig_ventricular_myocytes_ L2 - https://Insights.ovid.com/pubmed?pmid=19719944 DB - PRIME DP - Unbound Medicine ER -