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Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study.
Am J Otolaryngol. 2009 Sep-Oct; 30(5):312-7.AJ

Abstract

BACKGROUND

No diagnostic test had been specifically developed to diagnose nonallergic rhinitis (NAR). Also a negative nasal smear for eosinophils does not rule out the diagnosis. There is a significant diagnostic problem in patients with NAR. How can we solve this problem?

OBJECTIVES

Assessment of other cells than eosinophils present in the cytogram such as basophils, neutrophils, and goblet cells may help us to classify and management of diagnostic problem of rhinitis. We sought to characterize the cellular pattern of patients with allergic rhinitis (AR) and compare them with those of NAR.

METHODS

According to the skin prick test positivity or negativity, individuals were divided into AR and NAR groups, respectively. Allergic rhinitis group was further divided into seasonal, perennial, and mixed subgroups. Nonallergic rhinitis group was also divided into the following 5 subgroups according to the nasal smear cytologic result: basophilic, neutrophilic, eosinophilic, mixed, and nonallergic noninfectious type. So the frequency rates of the subgroups were calculated and also smear cytologic results were compared.

RESULTS

Frequency of AR was approximately equal to NAR in subjects with chronic rhinitis. Neutrophilic, eosinophilic, mixed, and nonallergic noninfectious types were the common types of NAR. An evident nasal eosinophilia was found in AR and eosinophilic NAR, whereas a higher percentage of goblet cells were determined in nonallergic noninfectious rhinitis. There is no significant difference between cytologic results from NAR and AR patients.

CONCLUSION

In the patient with positive skin test result, the presence of nasal eosinophilia strongly supports the diagnosis of AR. No diagnostic test had been specifically developed to diagnose chronic NAR. Also, a negative nasal smear for eosinophils does not rule out the diagnosis. Assessment of other cells present in the cytogram such as basophils, neutrophils, and goblet cells may also provide valuable information for differential diagnosis and management of these conditions.

Authors+Show Affiliations

Cerrahpasa Medical Faculty, Otolaryngology Department, University of Istanbul, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19720248

Citation

Canakcioglu, Salih, et al. "Evaluation of Nasal Cytology in Subjects With Chronic Rhinitis: a 7-year Study." American Journal of Otolaryngology, vol. 30, no. 5, 2009, pp. 312-7.
Canakcioglu S, Tahamiler R, Saritzali G, et al. Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. Am J Otolaryngol. 2009;30(5):312-7.
Canakcioglu, S., Tahamiler, R., Saritzali, G., Alimoglu, Y., Isildak, H., Guvenc, M. G., Acar, G. O., & Inci, E. (2009). Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. American Journal of Otolaryngology, 30(5), 312-7. https://doi.org/10.1016/j.amjoto.2008.06.015
Canakcioglu S, et al. Evaluation of Nasal Cytology in Subjects With Chronic Rhinitis: a 7-year Study. Am J Otolaryngol. 2009 Sep-Oct;30(5):312-7. PubMed PMID: 19720248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. AU - Canakcioglu,Salih, AU - Tahamiler,Rauf, AU - Saritzali,Gkioukxel, AU - Alimoglu,Yalcin, AU - Isildak,Huseyin, AU - Guvenc,Melih Guven, AU - Acar,Gul Ozbilen, AU - Inci,Ender, Y1 - 2009/03/06/ PY - 2008/02/08/received PY - 2008/06/03/revised PY - 2008/06/08/accepted PY - 2009/9/2/entrez PY - 2009/9/2/pubmed PY - 2009/10/27/medline SP - 312 EP - 7 JF - American journal of otolaryngology JO - Am J Otolaryngol VL - 30 IS - 5 N2 - BACKGROUND: No diagnostic test had been specifically developed to diagnose nonallergic rhinitis (NAR). Also a negative nasal smear for eosinophils does not rule out the diagnosis. There is a significant diagnostic problem in patients with NAR. How can we solve this problem? OBJECTIVES: Assessment of other cells than eosinophils present in the cytogram such as basophils, neutrophils, and goblet cells may help us to classify and management of diagnostic problem of rhinitis. We sought to characterize the cellular pattern of patients with allergic rhinitis (AR) and compare them with those of NAR. METHODS: According to the skin prick test positivity or negativity, individuals were divided into AR and NAR groups, respectively. Allergic rhinitis group was further divided into seasonal, perennial, and mixed subgroups. Nonallergic rhinitis group was also divided into the following 5 subgroups according to the nasal smear cytologic result: basophilic, neutrophilic, eosinophilic, mixed, and nonallergic noninfectious type. So the frequency rates of the subgroups were calculated and also smear cytologic results were compared. RESULTS: Frequency of AR was approximately equal to NAR in subjects with chronic rhinitis. Neutrophilic, eosinophilic, mixed, and nonallergic noninfectious types were the common types of NAR. An evident nasal eosinophilia was found in AR and eosinophilic NAR, whereas a higher percentage of goblet cells were determined in nonallergic noninfectious rhinitis. There is no significant difference between cytologic results from NAR and AR patients. CONCLUSION: In the patient with positive skin test result, the presence of nasal eosinophilia strongly supports the diagnosis of AR. No diagnostic test had been specifically developed to diagnose chronic NAR. Also, a negative nasal smear for eosinophils does not rule out the diagnosis. Assessment of other cells present in the cytogram such as basophils, neutrophils, and goblet cells may also provide valuable information for differential diagnosis and management of these conditions. SN - 1532-818X UR - https://www.unboundmedicine.com/medline/citation/19720248/Evaluation_of_nasal_cytology_in_subjects_with_chronic_rhinitis:_a_7_year_study_ DB - PRIME DP - Unbound Medicine ER -