Tags

Type your tag names separated by a space and hit enter

Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes.
Diabetes. 2009 Dec; 58(12):2749-56.D

Abstract

OBJECTIVE

The aim of this study was to investigate the impact of 9 days of bed rest on insulin secretion, insulin action, and whole-body glucose and fat metabolism in first-degree relative (FDR) and matched control (CON) subjects.

RESEARCH DESIGN AND METHODS

A total of 13 FDR and 20 CON subjects participated in the study. All were studied before and after 9 days of bed rest using the clamp technique combined with indirect calorimetry preceded by an intravenous glucose tolerance test. Glucose and glycerol turnover rates were studied using stable isotope kinetics.

RESULTS

Bed rest caused a significant decrease in whole-body insulin sensitivity in both groups. Hepatic insulin resistance was elevated in FDR subjects prior to bed rest and was significantly augmented by bed rest in FDR (P < 0.01) but not in CON (P = NS) subjects. The rate of whole-body lipolysis decreased during bed rest in both FDR and CON subjects, with no significant differences between the groups. Insulin resistance induced by bed rest was fully accounted for by the impairment of nonoxidative glucose metabolism in both groups (overall P < 0.001).

CONCLUSIONS

Whole-body insulin action in both insulin-resistant FDR and healthy CON subjects deteriorates with 9 days of bed rest, converging toward similar degrees of whole-body insulin resistance. FDR subjects exhibit hepatic insulin resistance (HIR), which, in contrast to CON subjects, deteriorates in response to physical inactivity. FDR subjects exhibit reduced insulin secretion when seen in relation to their degree of HIR but not peripheral insulin resistance.

Authors+Show Affiliations

Steno Diabetes Centre, Gentofte, Denmark. aagv@steno.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19720789

Citation

Alibegovic, Amra C., et al. "Impact of 9 Days of Bed Rest On Hepatic and Peripheral Insulin Action, Insulin Secretion, and Whole-body Lipolysis in Healthy Young Male Offspring of Patients With Type 2 Diabetes." Diabetes, vol. 58, no. 12, 2009, pp. 2749-56.
Alibegovic AC, Højbjerre L, Sonne MP, et al. Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes. Diabetes. 2009;58(12):2749-56.
Alibegovic, A. C., Højbjerre, L., Sonne, M. P., van Hall, G., Stallknecht, B., Dela, F., & Vaag, A. (2009). Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes. Diabetes, 58(12), 2749-56. https://doi.org/10.2337/db09-0369
Alibegovic AC, et al. Impact of 9 Days of Bed Rest On Hepatic and Peripheral Insulin Action, Insulin Secretion, and Whole-body Lipolysis in Healthy Young Male Offspring of Patients With Type 2 Diabetes. Diabetes. 2009;58(12):2749-56. PubMed PMID: 19720789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes. AU - Alibegovic,Amra C, AU - Højbjerre,Lise, AU - Sonne,Mette P, AU - van Hall,Gerrit, AU - Stallknecht,Bente, AU - Dela,Flemming, AU - Vaag,Allan, Y1 - 2009/08/31/ PY - 2009/9/2/entrez PY - 2009/9/2/pubmed PY - 2009/12/16/medline SP - 2749 EP - 56 JF - Diabetes JO - Diabetes VL - 58 IS - 12 N2 - OBJECTIVE: The aim of this study was to investigate the impact of 9 days of bed rest on insulin secretion, insulin action, and whole-body glucose and fat metabolism in first-degree relative (FDR) and matched control (CON) subjects. RESEARCH DESIGN AND METHODS: A total of 13 FDR and 20 CON subjects participated in the study. All were studied before and after 9 days of bed rest using the clamp technique combined with indirect calorimetry preceded by an intravenous glucose tolerance test. Glucose and glycerol turnover rates were studied using stable isotope kinetics. RESULTS: Bed rest caused a significant decrease in whole-body insulin sensitivity in both groups. Hepatic insulin resistance was elevated in FDR subjects prior to bed rest and was significantly augmented by bed rest in FDR (P < 0.01) but not in CON (P = NS) subjects. The rate of whole-body lipolysis decreased during bed rest in both FDR and CON subjects, with no significant differences between the groups. Insulin resistance induced by bed rest was fully accounted for by the impairment of nonoxidative glucose metabolism in both groups (overall P < 0.001). CONCLUSIONS: Whole-body insulin action in both insulin-resistant FDR and healthy CON subjects deteriorates with 9 days of bed rest, converging toward similar degrees of whole-body insulin resistance. FDR subjects exhibit hepatic insulin resistance (HIR), which, in contrast to CON subjects, deteriorates in response to physical inactivity. FDR subjects exhibit reduced insulin secretion when seen in relation to their degree of HIR but not peripheral insulin resistance. SN - 1939-327X UR - https://www.unboundmedicine.com/medline/citation/19720789/Impact_of_9_days_of_bed_rest_on_hepatic_and_peripheral_insulin_action_insulin_secretion_and_whole_body_lipolysis_in_healthy_young_male_offspring_of_patients_with_type_2_diabetes_ L2 - https://diabetes.diabetesjournals.org/lookup/pmidlookup?view=long&amp;pmid=19720789 DB - PRIME DP - Unbound Medicine ER -