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Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study.
Am J Epidemiol 2009; 170(7):901-9AJ

Abstract

Although there is some epidemiologic evidence that soy may reduce risk of osteoporotic fracture in women, it is not known whether this risk reduction also occurs for men. The authors examined gender-specific associations between soy intake and hip fracture risk in the Singapore Chinese Health Study, a prospective cohort of 63,257 Chinese living in Singapore. At recruitment between 1993 and 1998, each subject was administered a food frequency questionnaire and questions on medical history and lifestyle factors. As of December 31, 2006, 276 incident cases of hip fracture in men and 692 cases in women were identified via linkage with hospital discharge databases. For both genders, hip fracture risk was positively associated with cigarette smoking and was inversely associated with body mass index. There was a statistically significant association of tofu equivalents, soy protein, and isoflavones with hip fracture risk among women but not among men. Compared with women in the lowest quartile of intakes for tofu equivalents (<49.4 g/day), soy protein (<2.7 g/day), and isoflavones (<5.8 mg/1,000 kcal/day), those in the second-fourth quartiles exhibited 21%-36% reductions in risk (all P < 0.036). Risk levels were comparable across the second, third, and fourth quartiles of soy intake categories.

Authors+Show Affiliations

Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. ephkwp@nus.edu.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19720865

Citation

Koh, Woon-Puay, et al. "Gender-specific Associations Between Soy and Risk of Hip Fracture in the Singapore Chinese Health Study." American Journal of Epidemiology, vol. 170, no. 7, 2009, pp. 901-9.
Koh WP, Wu AH, Wang R, et al. Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study. Am J Epidemiol. 2009;170(7):901-9.
Koh, W. P., Wu, A. H., Wang, R., Ang, L. W., Heng, D., Yuan, J. M., & Yu, M. C. (2009). Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study. American Journal of Epidemiology, 170(7), pp. 901-9. doi:10.1093/aje/kwp220.
Koh WP, et al. Gender-specific Associations Between Soy and Risk of Hip Fracture in the Singapore Chinese Health Study. Am J Epidemiol. 2009 Oct 1;170(7):901-9. PubMed PMID: 19720865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender-specific associations between soy and risk of hip fracture in the Singapore Chinese Health Study. AU - Koh,Woon-Puay, AU - Wu,Anna H, AU - Wang,Renwei, AU - Ang,Li-Wei, AU - Heng,Derrick, AU - Yuan,Jian-Min, AU - Yu,Mimi C, Y1 - 2009/08/31/ PY - 2009/9/2/entrez PY - 2009/9/2/pubmed PY - 2009/10/7/medline SP - 901 EP - 9 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 170 IS - 7 N2 - Although there is some epidemiologic evidence that soy may reduce risk of osteoporotic fracture in women, it is not known whether this risk reduction also occurs for men. The authors examined gender-specific associations between soy intake and hip fracture risk in the Singapore Chinese Health Study, a prospective cohort of 63,257 Chinese living in Singapore. At recruitment between 1993 and 1998, each subject was administered a food frequency questionnaire and questions on medical history and lifestyle factors. As of December 31, 2006, 276 incident cases of hip fracture in men and 692 cases in women were identified via linkage with hospital discharge databases. For both genders, hip fracture risk was positively associated with cigarette smoking and was inversely associated with body mass index. There was a statistically significant association of tofu equivalents, soy protein, and isoflavones with hip fracture risk among women but not among men. Compared with women in the lowest quartile of intakes for tofu equivalents (<49.4 g/day), soy protein (<2.7 g/day), and isoflavones (<5.8 mg/1,000 kcal/day), those in the second-fourth quartiles exhibited 21%-36% reductions in risk (all P < 0.036). Risk levels were comparable across the second, third, and fourth quartiles of soy intake categories. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19720865/Gender_specific_associations_between_soy_and_risk_of_hip_fracture_in_the_Singapore_Chinese_Health_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp220 DB - PRIME DP - Unbound Medicine ER -