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Simvastatin attenuates intestinal ischemia/reperfusion induced injury in rat.
Folia Morphol (Warsz). 2009 Aug; 68(3):156-62.FM

Abstract

Ischaemia/reperfusion (I/R) injury is commonly seen in the field of intestine surgical interventions, shock, trauma, and many other clinical conditions. Simvastatin is known to have antioxidant and anti-inflammatory properties. This study investigated the effect of simvastatin administration in a warm intestinal I/R model on TNF-alpha, antioxidant enzymes and intestinal tissue morphology. Thirty-six male wistar rats underwent laparotomy under general anaesthesia. Simvastatin was administered from four days before ischaemia induction. The rats were divided in to three groups (n = 12): the sham group, the I/R group, and the I/R + simvastatin group. Intestinal ischaemia was induced by superior mesenteric artery ligation with microvascular clamps for 60 minutes, and after ischaemia, blood perfusion was released into the tissue and a reperfusion phase was started, which lasted for 3 hours. After 3 hours, the animals were sacrificed and serum and tissue obtained for biochemical and histological study. In the simvastatin treated group, intestinal tissue injury, TNF-alpha level, and tissue malondealdehyde levels were significantly lower than in the I/R group (p < 0.05). Glutathion peroxidase and superoxide dismutase levels were significantly higher in the simvastatin treated group than in the I/R group (p < 0.05). Simvastatin pretreatment reduced intestinal I/R injury and was associated with down- -regulation of serum TNF-alpha and tissue malondealdehyde level, and simvastatin administration maintained cellular antioxidant enzyme contents compared to the I/R group after 3 hours reperfusion time.

Authors+Show Affiliations

Faculty of Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran. Hajipourb@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19722159

Citation

Hajipour, B, et al. "Simvastatin Attenuates Intestinal Ischemia/reperfusion Induced Injury in Rat." Folia Morphologica, vol. 68, no. 3, 2009, pp. 156-62.
Hajipour B, Somi MH, Saberifar F, et al. Simvastatin attenuates intestinal ischemia/reperfusion induced injury in rat. Folia Morphol (Warsz). 2009;68(3):156-62.
Hajipour, B., Somi, M. H., Saberifar, F., Hemmati, M. R., Asl, N. A., Moein, A., Vatankhah, A. M., Nourazar, A. R., & Nasirizade, M. R. (2009). Simvastatin attenuates intestinal ischemia/reperfusion induced injury in rat. Folia Morphologica, 68(3), 156-62.
Hajipour B, et al. Simvastatin Attenuates Intestinal Ischemia/reperfusion Induced Injury in Rat. Folia Morphol (Warsz). 2009;68(3):156-62. PubMed PMID: 19722159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simvastatin attenuates intestinal ischemia/reperfusion induced injury in rat. AU - Hajipour,B, AU - Somi,M H, AU - Saberifar,F, AU - Hemmati,M R, AU - Asl,N A, AU - Moein,A, AU - Vatankhah,A M, AU - Nourazar,A R, AU - Nasirizade,M R, PY - 2009/9/2/entrez PY - 2009/9/2/pubmed PY - 2009/12/16/medline SP - 156 EP - 62 JF - Folia morphologica JO - Folia Morphol (Warsz) VL - 68 IS - 3 N2 - Ischaemia/reperfusion (I/R) injury is commonly seen in the field of intestine surgical interventions, shock, trauma, and many other clinical conditions. Simvastatin is known to have antioxidant and anti-inflammatory properties. This study investigated the effect of simvastatin administration in a warm intestinal I/R model on TNF-alpha, antioxidant enzymes and intestinal tissue morphology. Thirty-six male wistar rats underwent laparotomy under general anaesthesia. Simvastatin was administered from four days before ischaemia induction. The rats were divided in to three groups (n = 12): the sham group, the I/R group, and the I/R + simvastatin group. Intestinal ischaemia was induced by superior mesenteric artery ligation with microvascular clamps for 60 minutes, and after ischaemia, blood perfusion was released into the tissue and a reperfusion phase was started, which lasted for 3 hours. After 3 hours, the animals were sacrificed and serum and tissue obtained for biochemical and histological study. In the simvastatin treated group, intestinal tissue injury, TNF-alpha level, and tissue malondealdehyde levels were significantly lower than in the I/R group (p < 0.05). Glutathion peroxidase and superoxide dismutase levels were significantly higher in the simvastatin treated group than in the I/R group (p < 0.05). Simvastatin pretreatment reduced intestinal I/R injury and was associated with down- -regulation of serum TNF-alpha and tissue malondealdehyde level, and simvastatin administration maintained cellular antioxidant enzyme contents compared to the I/R group after 3 hours reperfusion time. SN - 0015-5659 UR - https://www.unboundmedicine.com/medline/citation/19722159/Simvastatin_attenuates_intestinal_ischemia/reperfusion_induced_injury_in_rat_ L2 - https://medlineplus.gov/cholesterolmedicines.html DB - PRIME DP - Unbound Medicine ER -